The phosphorylated pathway of serine biosynthesis affects sperm, embryo, and sporophyte development, and metabolism in Marchantia polymorpha [PDF]
Communications BiologySerine metabolism is involved in various biological processes. Here we investigate primary functions of the phosphorylated pathway of serine biosynthesis in a non-vascular plant Marchantia polymorpha by analyzing knockout mutants of MpPGDH encoding 3 ...
Mengyao Wang +17 more
doaj +2 more sources
Human macular Müller cells rely more on serine biosynthesis to combat oxidative stress than those from the periphery [PDF]
eLife, 2019 The human macula is more susceptible than the peripheral retina to developing blinding conditions such as age-related macular degeneration, diabetic retinopathy. A key difference between them may be the nature of their Müller cells.
Ting Zhang +9 more
doaj +2 more sources
Spatial metabolomics as a new avenue in plant developmental biology: insights into serine biosynthesis during spermatogenesis in Marchantia polymorpha [PDF]
Plant Signaling & BehaviorPlant development is a complex process governed by genetic regulatory networks in which metabolites play essential roles by modulating gene expression and cellular processes.
Hiromitsu Tabeta +2 more
doaj +2 more sources
Mitochondrial protein import determines lifespan through metabolic reprogramming and de novo serine biosynthesis [PDF]
Nature Communications, 2022 Mitochondrial function is linked to lifespan. Here the authors show that inhibition of mitochondrial protein import leads to a reduction in mitochondrial abundance and extends lifespan in Caenorhabditis elegans via activation of glycolysis and de novo ...
Eirini Lionaki +5 more
doaj +2 more sources
Novel regulatory mechanism of serine biosynthesis associated with 3-phosphoglycerate dehydrogenase in Arabidopsis thaliana [PDF]
Scientific Reports, 2017 The proteinogenic amino acid l-serine is a precursor for various essential biomolecules in all organisms. 3-Phosphoglycerate dehydrogenase (PGDH) is the first committed enzyme of the phosphorylated pathway of l-serine biosynthesis, and is regulated by ...
Eiji Okamura, Masami Yokota Hirai
doaj +2 more sources
PHGDH mediated serine biosynthesis metabolism suppresses vascular calcification [PDF]
Biology DirectBackground Vascular calcification is a major pathological process driving cardiovascular morbidity and mortality, yet effective therapies are lacking.
Liao Tan +3 more
doaj +2 more sources
Phosphoserine Aminotransferase1 Is Part of the Phosphorylated Pathways for Serine Biosynthesis and Essential for Light and Sugar-Dependent Growth Promotion [PDF]
Frontiers in Plant Science, 2018 The phosphorylated pathway of serine biosynthesis represents an important pathway in plants. The pathway consist of three reactions catalyzed by the phosphoglycerate dehydrogenase, the phosphoserine aminotransferase and the phosphoserine phosphatase, and
Sabine Wulfert, Stephan Krueger
doaj +2 more sources
Cell Reports, 2017 Targeting defects in metabolism is an underutilized strategy for the treatment of cancer. Arginine auxotrophy resulting from the silencing of argininosuccinate synthetase 1 (ASS1) is a common metabolic alteration reported in a broad range of aggressive ...
Jason M. Held +2 more
exaly +3 more sources
Epigenetic regulation of serine biosynthesis by PHF8 during neurogenesis [PDF]
EMBO ReportsProgenitor proliferation during neurodevelopment requires tight coordination of epigenetic regulation and metabolism. However, the crosstalk between these processes remains poorly understood.
Marta H Artes +16 more
doaj +2 more sources
m6A/IGF2BP3-driven serine biosynthesis fuels AML stemness and metabolic vulnerability [PDF]
Nature CommunicationsMetabolic reprogramming of amino acids represents a vulnerability in cancer cells, yet the mechanisms underlying serine metabolism in acute myeloid leukemia (AML) and leukemia stem/initiating cells (LSCs/LICs) remain unclear.
Feng Huang +19 more
doaj +2 more sources