Results 1 to 10 of about 129,457 (148)

Phosphoserine Aminotransferase1 Is Part of the Phosphorylated Pathways for Serine Biosynthesis and Essential for Light and Sugar-Dependent Growth Promotion [PDF]

Frontiers in Plant Science, 2018
The phosphorylated pathway of serine biosynthesis represents an important pathway in plants. The pathway consist of three reactions catalyzed by the phosphoglycerate dehydrogenase, the phosphoserine aminotransferase and the phosphoserine phosphatase, and
Stephan Krueger, Krueger Stephan
exaly   +4 more sources

Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers [PDF]

Cell Reports, 2017
Targeting defects in metabolism is an underutilized strategy for the treatment of cancer. Arginine auxotrophy resulting from the silencing of argininosuccinate synthetase 1 (ASS1) is a common metabolic alteration reported in a broad range of aggressive ...
Kenjiro Kami, Takashi Tsukamoto, Jason M Held   +2 more
exaly   +4 more sources

The phosphorylated pathway of serine biosynthesis affects sperm, embryo, and sporophyte development, and metabolism in Marchantia polymorpha [PDF]

Communications Biology
Serine metabolism is involved in various biological processes. Here we investigate primary functions of the phosphorylated pathway of serine biosynthesis in a non-vascular plant Marchantia polymorpha by analyzing knockout mutants of MpPGDH encoding 3 ...
Mengyao Wang, Hiromitsu Tabeta, Kinuka Ohtaka, Ayuko Kuwahara, Ryuichi Nishihama, Toshiki Ishikawa, Kiminori Toyooka, Mayuko Sato, Mayumi Wakazaki, Hiromichi Akashi, Hiroshi Tsugawa, Tsubasa Shoji, Yozo Okazaki, Keisuke Yoshida, Ryoichi Sato, Ali Ferjani, Takayuki Kohchi, Masami Yokota Hirai   +17 more
doaj   +2 more sources

p73 regulates serine biosynthesis in cancer [PDF]

Oncogene, 2013
Activation of serine biosynthesis supports growth and proliferation of cancer cells. Human cancers often exhibit overexpression of phosphoglycerate dehydrogenase (PHGDH), the metabolic enzyme that catalyses the reaction that diverts serine biosynthesis from the glycolytic pathway.
Ivano Amelio, Berna S Sayan, Massimiliano Agostini   +2 more
exaly   +8 more sources

Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy. [PDF]

Eur Heart J, 2022
Abstract Aims Genetic dilated cardiomyopathy (DCM) is a leading cause of heart failure. Despite significant progress in understanding the genetic aetiologies of DCM, the molecular mechanisms underlying the pathogenesis of familial DCM remain unknown, translating to a lack of disease-specific ...
Perea-Gil I, Seeger T, Bruyneel AAN, Termglinchan V, Monte E, Lim EW, Vadgama N, Furihata T, Gavidia AA, Arthur Ataam J, Bharucha N, Martinez-Amador N, Ameen M, Nair P, Serrano R, Kaur B, Feyen DAM, Diecke S, Snyder MP, Metallo CM, Mercola M, Karakikes I.   +21 more
europepmc   +3 more sources

Mitochondrial protein import determines lifespan through metabolic reprogramming and de novo serine biosynthesis [PDF]

Nature Communications, 2022
Mitochondrial function is linked to lifespan. Here the authors show that inhibition of mitochondrial protein import leads to a reduction in mitochondrial abundance and extends lifespan in Caenorhabditis elegans via activation of glycolysis and de novo ...
Eirini Lionaki, Ilias Gkikas, Ioanna Daskalaki, Maria-Konstantina Ioannidi, Maria I. Klapa, Nektarios Tavernarakis   +5 more
doaj   +2 more sources

Novel regulatory mechanism of serine biosynthesis associated with 3-phosphoglycerate dehydrogenase in Arabidopsis thaliana [PDF]

Scientific Reports, 2017
The proteinogenic amino acid l-serine is a precursor for various essential biomolecules in all organisms. 3-Phosphoglycerate dehydrogenase (PGDH) is the first committed enzyme of the phosphorylated pathway of l-serine biosynthesis, and is regulated by ...
Eiji Okamura, Masami Yokota Hirai
doaj   +2 more sources

Human macular Müller cells rely more on serine biosynthesis to combat oxidative stress than those from the periphery [PDF]

eLife, 2019
The human macula is more susceptible than the peripheral retina to developing blinding conditions such as age-related macular degeneration, diabetic retinopathy. A key difference between them may be the nature of their Müller cells.
Ting Zhang, Ling Zhu, Michele C Madigan, Wei Liu, Weiyong Shen, Svetlana Cherepanoff, Fanfan Zhou, Shaoxue Zeng, Jianhai Du, Mark C Gillies   +9 more
doaj   +2 more sources

PHGDH mediated serine biosynthesis metabolism suppresses vascular calcification [PDF]

Biology Direct
Background Vascular calcification is a major pathological process driving cardiovascular morbidity and mortality, yet effective therapies are lacking.
Liao Tan, Jie Liu, Ruizheng Shi, Yubo Liu   +3 more
doaj   +2 more sources

Spatial metabolomics as a new avenue in plant developmental biology: insights into serine biosynthesis during spermatogenesis in Marchantia polymorpha [PDF]

Plant Signaling & Behavior
Plant development is a complex process governed by genetic regulatory networks in which metabolites play essential roles by modulating gene expression and cellular processes.
Hiromitsu Tabeta, Mai Uzaki, Masami Yokota Hirai   +2 more
doaj   +2 more sources