The role of serine metabolism in lung cancer: From oncogenesis to tumor treatment [PDF]
Frontiers in Genetics, 2023 Metabolic reprogramming is an important hallmark of malignant tumors. Serine is a non-essential amino acid involved in cell proliferation. Serine metabolism, especially the de novo serine synthesis pathway, forms a metabolic network with glycolysis ...
Xijia Zhou +4 more
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Serine Metabolism Regulates YAP Activity Through USP7 in Colon Cancer [PDF]
Frontiers in Cell and Developmental Biology, 2021 Metabolic reprogramming is a vital factor in the development of many types of cancer, including colon cancer. Serine metabolic reprogramming is a major feature of tumor metabolism.
Xiaoya Zhao +14 more
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Recent progress in serine metabolism reprogramming in tumors and strategies for serine deprivation [PDF]
Frontiers in OncologyTumor cells undergo extensive metabolic reprogramming during malignant proliferation, with serine—a key nonessential amino acid—playing multiple roles in tumor metabolism.
Huimei Liu, Huimei Liu, Yanping Liu
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Targeting serine metabolism boosts antimycobacterial immunity during Mycobacterium tuberculosis H37Rv infection [PDF]
Molecules and Cells: Serine metabolism is pivotal in regulating immune cell function and molding the host microenvironment during infection, yet its impact on antimycobacterial immunity remains elusive.
Sang-Hun Son +7 more
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The role and research progress of serine metabolism in tumor cells [PDF]
Frontiers in OncologySerine is crucial for tumor initiation, progression, and adaptive immunity. Metabolic pathways for serine synthesis, acquisition, and utilization in tumors and tumor-associated cells are influenced by various physiological factors and the tumor ...
Hanning Lyu +6 more
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The mechanism of PKM2/HIF-1α axis polarizing TAMs by upregulating glucose-serine metabolism to promote melanoma progression [PDF]
Frontiers in ImmunologyBackgroundMelanoma is the most aggressive skin cancer. Tumor-associated macrophages (TAMs) promote melanoma progression through polarization, however, whether glucose-serine metabolism regulates TAMs polarization and the specific regulatory mechanism ...
Ying Yang +12 more
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Impaired glycolysis-derived serine metabolism as a key driver of podocyte injury with senescence [PDF]
Nature CommunicationsChronic kidney disease (CKD) is a major health issue, with podocyte injury with senescence playing a central role in glomerulosclerosis. This study investigates the link between glycolysis-derived serine metabolism and podocyte injury with senescence ...
Hongtu Hu +12 more
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Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism
Cell Reports, 2018 Summary: Cell proliferation can be dependent on the non-essential amino acid serine, and dietary restriction of serine inhibits tumor growth, but the underlying mechanisms remain incompletely understood.
Xia Gao +7 more
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Aminooxy acetic acid suppresses Th17-mediated psoriasis-like skin inflammation by inhibiting serine metabolism [PDF]
Frontiers in Pharmacology, 2023 Background: Psoriasis is a common chronic inflammatory skin disease characterized by an external red rash that is caused by abnormal proliferation and differentiation of keratinocytes and immune T cells. This study aimed to elucidate the role of aminooxy
Jong Yeong Lee +5 more
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FOXC1-mediated serine metabolism reprogramming enhances colorectal cancer growth and 5-FU resistance under serine restriction [PDF]
Cell Communication and SignalingColorectal cancer (CRC) is the most common gastrointestinal malignancy, and 5-Fluorouracil (5-FU) is the principal chemotherapeutic drug used for its treatment. However, 5-FU resistance remains a significant challenge.
Zhukai Chen +17 more
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