PHGDH Defines a Metabolic Subtype in Lung Adenocarcinomas with Poor Prognosis [PDF]
Cell Reports, 2017 Molecular signatures are emerging determinants of choice of therapy for lung adenocarcinomas. An evolving therapeutic approach includes targeting metabolic dependencies in cancers.
Boxi Zhang +2 more
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Advanced Science, 2023 Herein, we observed that nuclear localization of phosphoglycerate dehydrogenase (PHGDH) is associated with poor prognosis in liver cancer, and Phgdh is required for liver cancer progression in a mouse model.
Wencheng Zhu, Xiongjun Wang
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m6A modification and SUMOylation of PHGDH regulates ulcerative colitis through autophagy [PDF]
Cellular and Molecular Life SciencesBackground Ulcerative colitis (UC) is a chronic inflammatory bowel disorder with increasing incidence globally. However, the understanding of UC pathogenesis remains limited. Methods DSS-induced UC mouse model and lipopolysaccharide (LPS)-treated colonic
Hui Xue +5 more
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PHGDH-dependent serine metabolism in astrocytes: A key regulator of oxidative stress and pyroptosis in cerebral ischemia-reperfusion injury [PDF]
Redox BiologyPhosphoglycerate dehydrogenase (PHGDH) is a key molecule in the progression of Alzheimer's disease. Herein, we report that PHGDH exerts a significant influence on cerebral ischemia-reperfusion injury (CIRI).
Jimeng Zhang +15 more
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Exercise Reprograms the Spatial Function of Phosphoglycerate Dehydrogenase of a Pathogenic Nuclear Transcription Factor (PHGDH): A Narrative Review [PDF]
MetabolitesBackground: Alzheimer’s disease (AD) represents a significant therapeutic challenge, largely attributed to the complex interplay of genetic and non-genetic mechanisms. Among the latter, metabolic dysregulation has emerged as a critical factor influencing
Dong Yang, Wen Guo, Liang Guo
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PHGDH at the crossroads: metabolic plasticity, metastatic paradoxes, and therapeutic reconnaissance in cancer [PDF]
Journal of Biomedical SciencePhosphoglycerate dehydrogenase (PHGDH), the rate-limiting enzyme of the serine biosynthesis pathway (SSP), is a central metabolic hub and multifunctional oncoprotein that drives tumorigenesis through both canonical and non-canonical mechanisms.
Liang Hao +6 more
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XPR1 downregulation inhibits hepatocellular carcinoma progression by suppressing serine metabolism [PDF]
Redox BiologyXenotropic and polytropic retrovirus receptor 1 (XPR1) is highly expressed in various tumors and is associated with poor clinical prognosis, making it a proposed therapeutic target for cancer. However, the mechanism of XPR1 in tumorigenesis, particularly
Zi-qiang Liao +8 more
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Cell Reports, 2020 Summary: Mechanistic or mammalian target of rapamycin complex 1 (mTORC1) is an important regulator of effector functions, proliferation, and cellular metabolism in macrophages.
Jayne Louise Wilson +2 more
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PHGDH drives 5-FU chemoresistance in colorectal cancer through the Hedgehog signaling [PDF]
Journal of Experimental & Clinical Cancer ResearchBackground Phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme in the de novo Serine synthesis pathway (SSP), a highly regulated pathway overexpressed in several tumors.
Caterina Mancini +24 more
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Phosphoglycerate dehydrogenase stabilizes protein kinase C delta type mRNA to promote hepatocellular carcinoma progression [PDF]
Signal Transduction and Targeted TherapyMetabolic reprogramming not only reshapes cellular bioenergetics but also profoundly influences RNA metabolism through metabolite signaling and the RNA-binding activities of metabolic enzymes.
Bin Cheng +9 more
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