Results 1 to 10 of about 5,503 (166)

Deciphering the Functional Mechanisms of eIF3f in Tumors and Exploring Targeted Therapies. [PDF]

Pharmacol Res Perspect
ABSTRACT Eukaryotic translation initiation factor 3 subunit F (eIF3f) is a critical component of the eIF3 complex and plays a pivotal role in diverse biological processes, including cell proliferation, apoptosis, adhesion, and transcriptional regulation.
Hao Y, Shao J, Lian N, Bian M.
europepmc   +2 more sources

Phosphoglycerate Dehydrogenase Overexpression Inhibits Ferroptosis to Repress Calcification of Human Coronary Artery Vascular Smooth Muscle Cells via the P53/SLC7A11 Pathway

International Journal of General Medicine
Yuhai Zou,1,* Dongdong Li,1,* Ge Guan,1 Wenting Liu2 1Department of Cardiology, General Hospital of Southern Theatre Command of PLA, Guangzhou, 510010, People’s Republic of China; 2Department of Otorhinolaryngology, Guangzhou First People’s ...
Zou Y, Li D, Guan G, Liu W
doaj  

IGF2BP2-driven serine metabolism promotes the progression of thyroid carcinoma via m⁶A-PHGDH. [PDF]

J Transl Med
Zhang Y, Xiao Z, Dong X, Wang Q.
europepmc   +1 more source

PHGDH-mediated serine synthesis reduces oligodendrocyte death by sustaining GSH and NADPH levels after brain ischemia. [PDF]

Front Pharmacol
Zhang Z, Tan J, Lv M, Duan Z, Wang C, Gao M, Cui Y, Feng Y.   +7 more
europepmc   +1 more source

Co-morbid biomarkers for sarcopenic obesity associated with gut microbiota metabolites: From burden to treatment. [PDF]

PLoS Comput Biol
Wang J, Li H, Shi W, Ren X, Liu Y, Mao L, Wang D, Zhang T, Zhang Z, Zheng H, Yang X, Yao M, Chen Z.   +12 more
europepmc   +1 more source

Targeting the noncanonical function of metabolic enzyme PHGDH in driving PD-L1 expression and cancer immune evasion. [PDF]

Cell Rep Med
Liu J, Wang W, Sun Y, Huang S, Borole A, Zheng H, Hu W, Feng Z.   +7 more
europepmc   +1 more source

Integrative analysis and functional validation identified palmitoylated PHGDH as a therapeutic target for colon adenocarcinoma. [PDF]

Cell Oncol (Dordr)
Song Y, Lin L, Liu D, Zhu M, Wang P, Li K, Li A, Chen K, Ye Z.   +8 more
europepmc   +1 more source

PHGDH phosphorylation mediated by WNK1 serves as a dual marker of metabolic vulnerability and responsiveness to oxaliplatin treatment. [PDF]

Proc Natl Acad Sci U S A
Fang S, Jin G, Yan M, Song Y, Zhao S, Zhang C, Shao Y, Zhao K, Liu M, Wang Z, Jia X, Guo Q, Guo M, Wang M, Guo Z, Dong Z.   +15 more
europepmc   +1 more source

PHGDH mediated serine biosynthesis metabolism suppresses vascular calcification. [PDF]

Biol Direct
Tan L, Liu J, Shi R, Liu Y.
europepmc   +1 more source

RNA-binding activity of PHGDH drives amyloid-beta production in a human brain organoid model of sporadic Alzheimer's disease. [PDF]

Proc Natl Acad Sci U S A
Chen J, Xu M, Xu M, Liu Y, Hadi F, Xue S, Chien S, Zhong S.   +7 more
europepmc   +1 more source