Results 1 to 10 of about 5,734 (107)

Elevated Nuclear PHGDH Synergistically Functions with cMyc to Reshape the Immune Microenvironment of Liver Cancer

Advanced Science, 2023
Herein, we observed that nuclear localization of phosphoglycerate dehydrogenase (PHGDH) is associated with poor prognosis in liver cancer, and Phgdh is required for liver cancer progression in a mouse model.
Hu Zhou, Wencheng Zhu, Xiongjun Wang
exaly   +2 more sources

PHGDH Promotes Synovial Aggression and Inflammation via Upregulating ADRA2A Expression in Rheumatoid Arthritis [PDF]

Cells
Objectives: The role of Phosphoglycerate Dehydrogenase (PHGDH), the first key enzyme in the serine biosynthesis pathway, is important in controlling cancer survival; however, its role in rheumatoid arthritis (RA) remains unknown.
Kai Sun, Ting Liu, Xuanxian Xu, Huan Dong, Huijuan Hu, Chenxi Peng, Xiaofan Ge, Liuqin Liang, Youjun Xiao, Hanshi Xu, Qian Qiu   +10 more
doaj   +2 more sources

Characterization of PHGDH expression in bladder cancer: potential targeting therapy with gemcitabine/cisplatin and the contribution of promoter DNA hypomethylation

Molecular Oncology, 2020
d‐3‐Phosphoglycerate dehydrogenase (PHGDH) conducts an important step in the synthesis of serine. Importantly, the PHGDH gene is often amplified in certain cancers.
Masaya Yonemori, Hideki Enokida, Hirofumi Yoshino   +2 more
exaly   +2 more sources

Identification of Novel Natural Inhibitors to Human 3-Phosphoglycerate Dehydrogenase (PHGDH) for Cancer Treatment

Molecules, 2022
Targeting the serine biosynthesis pathway enzymes has turned up as a novel strategy for anti-cancer therapeutics. 3- Phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme that catalyzes the conversion of 3-Phosphoglyceric acid (3-PG) into 3 ...
Azhar Rasul, Farhat Jabeen, Salma Sultana   +2 more
exaly   +3 more sources

PHGDH loss promotes hypoxia tolerance through glycolytic reprogramming and enhanced HIF-1 activity [PDF]

Cell Death Discovery
Radiotherapy is widely used in the treatment of lung cancer; a number of intrinsic and extrinsic mechanisms of resistance exist, including hypoxia. Targeting metabolic pathways that support redox homeostasis has been proposed as a strategy to enhance ...
Eduard Petrosyan, Louise A. W. Martin, Isabelle Legge, John Walsby-Tickle, Adam C. Sedgwick, Mark A. Hill, James S. O. McCullagh, Monica M. Olcina, Ester M. Hammond   +8 more
doaj   +2 more sources

PHGDH restricts porcine reproductive and respiratory syndrome virus replication by sustaining cellular antioxidant capacity and redox homeostasis [PDF]

Microbiology Spectrum
Porcine reproductive and respiratory syndrome virus (PRRSV) remains a major threat to the swine industry. Although redox imbalance and oxidative stress are known to favor PRRSV infection, the host determinants that preserve redox homeostasis during PRRSV
Zhangping Yu, Qiongqiong Zhou, Peng Gao, Yongning Zhang, Xinna Ge, Jun Han, Xin Guo, Lei Zhou, Hanchun Yang   +8 more
doaj   +2 more sources

m6A modification and SUMOylation of PHGDH regulates ulcerative colitis through autophagy [PDF]

Cellular and Molecular Life Sciences
Background Ulcerative colitis (UC) is a chronic inflammatory bowel disorder with increasing incidence globally. However, the understanding of UC pathogenesis remains limited. Methods DSS-induced UC mouse model and lipopolysaccharide (LPS)-treated colonic
Hui Xue, Dandan Wang, Chengjian Pang, Yue Shen, Jingjing Xu, Lize Zhang   +5 more
doaj   +2 more sources

PHGDH-dependent serine metabolism in astrocytes: A key regulator of oxidative stress and pyroptosis in cerebral ischemia-reperfusion injury [PDF]

Redox Biology
Phosphoglycerate dehydrogenase (PHGDH) is a key molecule in the progression of Alzheimer's disease. Herein, we report that PHGDH exerts a significant influence on cerebral ischemia-reperfusion injury (CIRI).
Jimeng Zhang, Yaowen Luo, Changcai Xie, Min Zhang, Heyao Qin, Yuefei Zhou, Xiuquan Wu, Chenchen Hu, Feiming Hu, Xiaowei Fei, Hongchen Zhang, Juan Li, Yihao Fu, Yunchao Yuan, Shuya Yang, Dakuan Gao   +15 more
doaj   +2 more sources

Inverse Data-Driven Modeling and Multiomics Analysis Reveals Phgdh as a Metabolic Checkpoint of Macrophage Polarization and Proliferation

Cell Reports, 2020
Summary: Mechanistic or mammalian target of rapamycin complex 1 (mTORC1) is an important regulator of effector functions, proliferation, and cellular metabolism in macrophages.
Monika Linke, Arvand Haschemi, Markus Hengstschläger   +2 more
exaly   +3 more sources

PHGDH Defines a Metabolic Subtype in Lung Adenocarcinomas with Poor Prognosis

Cell Reports, 2017
Molecular signatures are emerging determinants of choice of therapy for lung adenocarcinomas. An evolving therapeutic approach includes targeting metabolic dependencies in cancers.
Helin Vakifahmetoglu-Norberg, Per Hydbring, Gorbatchev Ambroise   +2 more
exaly   +3 more sources