D-3-Phosphoglycerate Dehydrogenase [PDF]
Frontiers in Molecular Biosciences, 2018 l-Serine is the immediate precursor of d-serine, a major agonist of the N-methyl-d-aspartate (NMDA) receptor. l-Serine is a pivotal amino acid since it serves as a precursor to a large number of essential metabolites besides d-serine.
Gregory A. Grant, Gregory A. Grant
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Targeting phosphoglycerate dehydrogenase in multiple myeloma [PDF]
Experimental Hematology & Oncology, 2021 Background Multiple myeloma (MM) is a hematological malignancy characterized by the clonal expansion of plasma cells in the bone marrow. To date, this disease is still incurable and novel therapeutic approaches are required.
Samah Elsaadi +9 more
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Phosphoglycerate dehydrogenase and Alzheimer’s disease [PDF]
EXCLI Journal : Experimental and Clinical SciencesEXCLI Journal; 24:Doc401; ISSN 1611 ...
Quan-Ying Liu, Shuang-Qing Zhang
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Phosphoglycerate dehydrogenase positively regulates the proliferation of chicken muscle cells [PDF]
Poultry Science, 2022 : Phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme in the serine synthesis pathway. However, the regulatory role of PHGDH in muscle development is unclear.
Han Wang +7 more
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Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence [PDF]
Nature Communications, 2023 Little is known about the role of glycolysis in cellular senescence. Here, authors report that glycolysis-derived serine biosynthesis activates PKM2 to phosphorylate histone H3T11, prevent cell senescence, and promote healthy aging.
Yinsheng Wu +9 more
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Identification of Novel Natural Inhibitors to Human 3-Phosphoglycerate Dehydrogenase (PHGDH) for Cancer Treatment [PDF]
Molecules, 2022 Targeting the serine biosynthesis pathway enzymes has turned up as a novel strategy for anti-cancer therapeutics. 3- Phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme that catalyzes the conversion of 3-Phosphoglyceric acid (3-PG) into 3 ...
Ayesha Sadiqa +4 more
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Designing Cyclic-Constrained Peptides to Inhibit Human Phosphoglycerate Dehydrogenase [PDF]
Molecules, 2023 Although loop epitopes at protein-protein binding interfaces often play key roles in mediating oligomer formation and interaction specificity, their binding sites are underexplored as drug targets owing to their high flexibility, relatively few hot spots,
Xiaoyu Qing +4 more
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Biochemical and Biophysical Characterization of Recombinant Human 3-Phosphoglycerate Dehydrogenase. [PDF]
Int J Mol Sci, 2021 The human enzyme D-3-phosphoglycerate dehydrogenase (hPHGDH) catalyzes the reversible dehydrogenation of 3-phosphoglycerate (3PG) into 3-phosphohydroxypyruvate (PHP) using the NAD+/NADH redox cofactor, the first step in the phosphorylated pathway ...
Murtas G +4 more
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3-Phosphoglycerate dehydrogenase: a potential target for cancer treatment. [PDF]
Cell Oncol (Dordr), 2021 Metabolic changes have been recognized as an important hallmark of cancer cells. Cancer cells can promote their own growth and proliferation through metabolic reprogramming. Particularly, serine metabolism has frequently been reported to be dysregulated in tumor cells.
Li M +7 more
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Moonlighting functions of phosphoglycerate dehydrogenase in cancer
Cell ReportsSummary: Phosphoglycerate dehydrogenase (PHGDH) is traditionally known for catalyzing the conversion of 3-phosphoglycerate (3-PG) to 3-phosphonooxypyruvate (3-PHP), a key step in the de novo synthesis of serine.
Chuanlong Wang +5 more
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