Phosphoglycerate dehydrogenase genes differentially affect Arabidopsis metabolism and development [PDF]
, 2021 [EN] Unlike animals, plants possess diverse L-serine (Ser) biosynthetic pathways. One of them, the Phosphorylated Pathway of Serine Biosynthesis (PPSB) has been recently described as essential for embryo, pollen and root development, and required for ...
Rosa-Tellez, Sara +7 more
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Nature Communications, 2023 The role of protein arginine methylation in serine metabolism of cancer cells in hepatocellular carcinoma (HCC) remains to be explored. Here, the authors show that phosphoglycerate dehydrogenase (PHGDH) is activated by PRMT1-mediated R236 methylation ...
Kui Wang +13 more
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Lactate Limits T Cell Proliferation via the NAD(H) Redox State
Cell Reports, 2020 Summary: Immune cell function is influenced by metabolic conditions. Low-glucose, high-lactate environments, such as the placenta, gastrointestinal tract, and the tumor microenvironment, are immunosuppressive, especially for glycolysis-dependent effector
William J. Quinn, III +22 more
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Mechanism Reveals a Novel Site for Allosteric Inhibition of Carcinogenic Activity of Human 3-Phosphoglycerate Dehydrogenase [PDF]
, 2023 3-Phosphoglycerate Dehydrogenase (PHGDH) is primarily known for catalyzing the oxidation of 3-phosphoglycerate (3PG) to 3-phosphohydroxypyvurate (3PHP) by reducing NAD+ to NADH, an important step during L-serine biosynthesis in human cells, however, it ...
Kshatresh, Dubey +2 more
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 The small-molecule inhibitor of phosphoglycerate dehydrogenase, NCT-503, reduces incorporation of glucose-derived carbons into serine in vitro.
Birte Arlt +6 more
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Targeting one-carbon metabolism requires mTOR inhibition: a new therapeutic approach in osteosarcoma
Molecular & Cellular Oncology, 2021 The rate-limiting enzyme of serine biosynthesis, 3-phosphoglycerate dehydrogenase (PHGDH), contributes to rapid growth and proliferation when it is overexpressed in cancer.
Richa Rathore, Brian Van Tine
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Comparing the folding and misfolding energy landscapes of phosphoglycerate kinase. [PDF]
, 2011 Partitioning of polypeptides between protein folding and amyloid formation is of outstanding pathophysiological importance. Using yeast phosphoglycerate kinase as model, here we identify the features of the energy landscape that decide the fate of the ...
Gottfried Köhler +8 more
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Cloning, sequencing and expression of rat liver 3-phosphoglycerate dehydrogenase [PDF]
, 1997 Rat liver d-3-phosphoglycerate dehydrogenase was purified to homogeneity and digested with trypsin, and the sequences of two peptides were determined. This sequence information was used to screen a rat hepatoma cDNA library. Among 11 positive clones, two
Achouri, Younes +3 more
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Cloning and sequence analysis of cDNAs encoding the cytosolic precursors of subunits GapA and GapB of chloroplast glyceraldehyde-3-phosphate dehydrogenase from pea and spinach [PDF]
, 1989 Chloroplast glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is composed of two different subunits, GapA and GapB. cDNA clones containing the entire coding sequences of the cytosolic precursors for GapA from pea and for GapB from pea and spinach have ...
Soll, Jürgen +3 more
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3-phosphoglycerate dehydrogenase gene polymorphism amongst patients with thyroid gland cancer [PDF]
Medicinski Podmladak, 2016 Introduction: Thyroid gland cancer is a rare malignancy in the male population, accounting for up to 2% of all cancers, but it is the most common cancer of the endocrine system, making up to 95% of all estimated new endocrine cancer cases each year ...
Pjevalica Jelena +2 more
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