Lactate Limits T Cell Proliferation via the NAD(H) Redox State
Cell Reports, 2020 Summary: Immune cell function is influenced by metabolic conditions. Low-glucose, high-lactate environments, such as the placenta, gastrointestinal tract, and the tumor microenvironment, are immunosuppressive, especially for glycolysis-dependent effector
William J. Quinn, III +22 more
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Mechanism Reveals a Novel Site for Allosteric Inhibition of Carcinogenic Activity of Human 3-Phosphoglycerate Dehydrogenase [PDF]
, 2023 3-Phosphoglycerate Dehydrogenase (PHGDH) is primarily known for catalyzing the oxidation of 3-phosphoglycerate (3PG) to 3-phosphohydroxypyvurate (3PHP) by reducing NAD+ to NADH, an important step during L-serine biosynthesis in human cells, however, it ...
Kshatresh, Dubey +2 more
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 The small-molecule inhibitor of phosphoglycerate dehydrogenase, NCT-503, reduces incorporation of glucose-derived carbons into serine in vitro.
Birte Arlt +6 more
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Targeting one-carbon metabolism requires mTOR inhibition: a new therapeutic approach in osteosarcoma
Molecular & Cellular Oncology, 2021 The rate-limiting enzyme of serine biosynthesis, 3-phosphoglycerate dehydrogenase (PHGDH), contributes to rapid growth and proliferation when it is overexpressed in cancer.
Richa Rathore, Brian Van Tine
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Comparing the folding and misfolding energy landscapes of phosphoglycerate kinase. [PDF]
, 2011 Partitioning of polypeptides between protein folding and amyloid formation is of outstanding pathophysiological importance. Using yeast phosphoglycerate kinase as model, here we identify the features of the energy landscape that decide the fate of the ...
Gottfried Köhler +8 more
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Cloning, sequencing and expression of rat liver 3-phosphoglycerate dehydrogenase [PDF]
, 1997 Rat liver d-3-phosphoglycerate dehydrogenase was purified to homogeneity and digested with trypsin, and the sequences of two peptides were determined. This sequence information was used to screen a rat hepatoma cDNA library. Among 11 positive clones, two
Achouri, Younes +3 more
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Cloning and sequence analysis of cDNAs encoding the cytosolic precursors of subunits GapA and GapB of chloroplast glyceraldehyde-3-phosphate dehydrogenase from pea and spinach [PDF]
, 1989 Chloroplast glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is composed of two different subunits, GapA and GapB. cDNA clones containing the entire coding sequences of the cytosolic precursors for GapA from pea and for GapB from pea and spinach have ...
Soll, Jürgen +3 more
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3-phosphoglycerate dehydrogenase gene polymorphism amongst patients with thyroid gland cancer [PDF]
Medicinski Podmladak, 2016 Introduction: Thyroid gland cancer is a rare malignancy in the male population, accounting for up to 2% of all cancers, but it is the most common cancer of the endocrine system, making up to 95% of all estimated new endocrine cancer cases each year ...
Pjevalica Jelena +2 more
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Memorias do Instituto Oswaldo Cruz, 2015 Trypanosoma evansi, which causes surra, is descended from Trypanosoma brucei brucei, which causes nagana. Although both parasites are presumed to be metabolically similar, insufficient knowledge of T. evansi precludes a full comparison.
S Andrea Moreno, Mayerly Nava
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Dynamic modelling under uncertainty: the case of Trypanosoma brucei energy metabolism [PDF]
, 2012 Kinetic models of metabolism require detailed knowledge of kinetic parameters. However, due to measurement errors or lack of data this knowledge is often uncertain.
Achcar, Fiona, +36 more
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