Results 1 to 10 of about 116,907 (132)

Phosphoserine Aminotransferase Pathogenetic Variants in Serine Deficiency Disorders: A Functional Characterization [PDF]

Biomolecules, 2023
In humans, the phosphorylated pathway (PP) converts the glycolytic intermediate D-3-phosphoglycerate (3-PG) into L-serine through the enzymes 3-phosphoglycerate dehydrogenase, phosphoserine aminotransferase (PSAT) and phosphoserine phosphatase.
Stefano Bettati, Davide Cavazzini, Annalisa Bianchera   +2 more
exaly   +5 more sources

Prognostic microRNAs associated with phosphoserine aminotransferase 1 in gastric cancer as markers of bone metastasis [PDF]

Frontiers in Genetics, 2022
This study analyzed PSAT1-targeted miRNAs as a prognostic predictor for gastric cancer. The relationship between the clinical manifestations of gastric cancer in patients and phosphoserine aminotransferase 1 (PSAT1) was analyzed using correlation ...
Jingwei Ma, Meng Zhu, Xiaofeng Ye, Bo Wu, Tao Wang, Muyuan Ma, Tao Li, Ning Zhang   +7 more
doaj   +3 more sources

Overexpression of Phosphoserine Aminotransferase (PSAT)-Enhanced Cadmium Resistance and Accumulation in Duckweed (Lemna turionifera 5511) [PDF]

Plants
Cadmium (Cd) hampers plant growth and harms photosynthesis. Glutamate (Glu) responds to Cd stress and activates the Ca2+ signaling pathway in duckweed, emphasizing Glu’s significant role in Cd stress.
Xu Ma, Yumeng Jiang, Ziyang Qu, Yunwen Yang, Wenqiao Wang, Yuman He, Yiqi Yu, Ximeng Luo, Yuanyuan Liu, Wenqian Han, Qiqi Di, Lin Yang, Yong Wang   +12 more
doaj   +3 more sources

Nuclear Pyruvate Kinase M2 (PKM2) Contributes to Phosphoserine Aminotransferase 1 (PSAT1)-Mediated Cell Migration in EGFR-Activated Lung Cancer Cells [PDF]

Cancers, 2021
Simple Summary Alternative functions for metabolic proteins have recently been shown to drive cancer growth. These may include differential enzymatic activity or novel protein associations.
James A Bradley, Brian F Clem, Traci L Kruer   +2 more
exaly   +3 more sources

Tree shrew model of early diabetic retinopathy reveals microvascular dysfunction and identifies phosphoserine aminotransferase 1 as a novel therapeutic target [PDF]

Animal Models and Experimental Medicine
Background Diabetic retinopathy (DR) is the most significant manifestation of diabetic microangiopathy. The existing tree shrew model of DR has dysfunctional retinal short wave sensitivity (SWS) cones and retinal ganglion cells, but it remains unclear ...
Min Qiu, Shurui Huo, Wenguang Wang, Na Li, Qingwei Zeng, Xiaomei Sun, Jiejie Dai, Pinfen Tong, Yuanyuan Han, Ling Zhao, Caixia Lu   +10 more
doaj   +3 more sources

Phosphoserine aminotransferase deficiency diagnosed by whole‐exome sequencing and LC–MS/MS reanalysis: A case report and review of literature [PDF]

Molecular Genetics & Genomic Medicine
Background Phosphoserine aminotransferase deficiency (PSATD) is an autosomal recessive disorder associated with hypertonia, psychomotor retardation, and acquired microcephaly.
Jiaci Li, Xinping Wei, Yuchen Sun, Xiaofang Chen, Ying Zhang, Xiaoyu Cui, Jianbo Shu, Dong Li, Chunquan Cai   +8 more
doaj   +3 more sources

Phosphoserine aminotransferase 1 is associated to poor outcome on tamoxifen therapy in recurrent breast cancer [PDF]

Scientific Reports, 2017
In a previous study, we detected a significant association between phosphoserine aminotransferase 1 (PSAT1) hyper-methylation and mRNA levels to outcome to tamoxifen treatment in recurrent disease.
Tommaso De Marchi, Mieke A. Timmermans, Anieta M. Sieuwerts, Marcel Smid, Maxime P. Look, Nicolai Grebenchtchikov, Fred C. G. J. Sweep, Jan G. Smits, Viktor Magdolen, Carolien H. M. van Deurzen, John A. Foekens, Arzu Umar, John W. Martens   +12 more
doaj   +3 more sources

Structural Analysis of Phosphoserine Aminotransferase (Isoform 1) From Arabidopsis thaliana– the Enzyme Involved in the Phosphorylated Pathway of Serine Biosynthesis [PDF]

Frontiers in Plant Science, 2018
Phosphoserine aminotransferase (PSAT) is a pyridoxal 5′-phosphate (PLP)-dependent enzyme that catalyzes the conversion of 3-phosphohydroxypyruvate (3-PHP) to 3-phosphoserine (PSer) in an L-glutamate (Glu)-linked reversible transamination reaction.
Bartosz Sekula, Milosz Ruszkowski, Zbigniew Dauter   +2 more
doaj   +3 more sources

MicroRNA-365 suppresses cell growth and invasion in esophageal squamous cell carcinoma by modulating phosphoserine aminotransferase 1 [PDF]

Cancer Management and Research, 2018
Changjiang Sun,1 Xizhi Zhang,1 Yong Chen,1 Qingqing Jia,1 Jianqi Yang,1 Yusheng Shu2 1Department of Oncology, Subei People’s Hospital of Jiangsu Province, Yangzhou, Jiangsu, China; 2Department of Thoracic and Cardiovascular Surgery, Subei People ...
Sun C, Zhang X, Chen Y, Jia Q, Yang J, Shu Y   +5 more
doaj   +3 more sources

Molecular Structure of Phosphoserine Aminotransferase from Saccharomyces cerevisiae. [PDF]

Int J Mol Sci, 2023
Phosphoserine aminotransferase (PSAT) is a pyridoxal 5′-phosphate-dependent enzyme involved in the second step of the phosphorylated pathway of serine biosynthesis.
Jang J, Chang JH.
europepmc   +2 more sources