Results 1 to 10 of about 116,489 (212)

Structure‐ and Data‐Driven Protein Engineering of Transaminases for Improving Activity and Stereoselectivity

Angewandte Chemie - International Edition, 2023
Amine transaminases (ATAs) are powerful biocatalysts for the stereoselective synthesis of chiral amines. Machine learning provides a promising approach for protein engineering, but activity prediction models for ATAs remain elusive due to the difficulty ...
Yu-Fei Ao, Chao Xiang, Marian J Menke
exaly   +2 more sources

Elevations in Liver Transaminases in COVID-19: (How) Are They Related?

Frontiers in Medicine, 2021
Liver involvement in COVID-19 is not yet well-understood, but elevations in liver transaminases have been described to occur in 14–53% of the cases and are more frequently seen in severe disease.
Henrique Pott-Junior, Rafael Luis Luporini, Marcia R Cominetti   +2 more
exaly   +2 more sources

Shifting the pH Optima of (R)-Selective Transaminases by Protein Engineering

International Journal of Molecular Sciences, 2022
Amine transaminases (ATAs) are powerful biocatalysts for the stereoselective synthesis of chiral amines. However, wild-type ATAs usually show pH optima at slightly alkaline values and exhibit low catalytic activity under physiological conditions.
Chao Xiang, Yu-Fei Ao, Matthias Höhne   +2 more
exaly   +2 more sources

Chemoenzymatic Approaches to the Synthesis of the Calcimimetic Agent Cinacalcet Employing Transaminases and Ketoreductases

Advanced Synthesis and Catalysis, 2018
Several chemoenzymatic routes have been explored for the preparation of cinacalcet, a calcimimetic agent. Transaminases (TAs) and ketoreductases (KREDs) turned out to be useful biocatalysts for the preparation of key optically active precursors.
Nicolas Ríos-Lombardía, Wolfgang Kroutil, Ana I Benítez-Mateos   +2 more
exaly   +2 more sources

Elevated Transaminases: Does It Always Warrant a Liver Biopsy? Lessons Learned From Pompe Disease [PDF]

JIMD Reports
Pompe disease (PD) is an autosomal recessive disorder caused by pathogenic variants in GAA, resulting in acid alpha‐glucosidase (GAA) deficiency and lysosomal glycogen accumulation.
Alicia Khazzeka, Rebecca L. Koch, Jeong‐A. Lim, Jeremy D. Ward, Jessica Doxey, William R. Jeck, Priya S. Kishnani   +6 more
doaj   +2 more sources

Expanding the phenotype of neurological manifestations of dengue fever: Acute necrotizing encephalopathy

Indian Pediatrics Case Reports, 2021
Background: Neurological manifestations following dengue fever are increasingly reported and include encephalopathy, encephalitis, neuro-ophthalmic manifestations or Guillain–Barre syndrome-like presentation.
Arpit Mittal, Sonu Kumar, Radhamohan Rana, Jaya Shankar Kaushik   +3 more
doaj   +1 more source

Role of Nutrition in the Etiopathogenesis and Prevention of Nonalcoholic Fatty Liver Disease (NAFLD) in a Group of Obese Adults

Medicina, 2023
Nonalcoholic fatty liver disease (NAFLD) is liver damage characterized by an accumulation of triglycerides in hepatocytes of >5% (due to an alteration of the balance of the lipid metabolism in favour of lipogenesis compared to lipolysis) that is not ...
Daniela Metro, Martina Buda, Luigi Manasseri, Francesco Corallo, Davide Cardile, Viviana Lo Buono, Angelo Quartarone, Lilla Bonanno   +7 more
doaj   +1 more source

To the Understanding of Catalysis by D-Amino Acid Transaminases: A Case Study of the Enzyme from Aminobacterium colombiense

Molecules, 2023
Pyridoxal-5′-phosphate (PLP)-dependent transaminases are highly efficient biocatalysts for stereoselective amination. D-amino acid transaminases can catalyze stereoselective transamination producing optically pure D-amino acids.
S. A. Shilova, M. Khrenova, I. O. Matyuta, A. Nikolaeva, T. Rakitina, N. Klyachko, M. Minyaev, K. Boyko, V. Popov, E. Y. Bezsudnova   +9 more
semanticscholar   +1 more source

Effects of folic acid supplementation on liver enzymes, lipid profile, and insulin resistance in patients with non-alcoholic fatty liver disease: A randomized controlled trial

Advanced Biomedical Research, 2023
Background: Previous evidence revealed an association between folate deficiency and non-alcoholic fatty liver disease (NAFLD). This study is the first one investigating the effects of folic acid on hepatic steatosis grade, liver enzymes, insulin ...
Mohamad Reza Molaqanbari, Shadi Zarringol, Hamid Reza Talari, Mohsen Taghizadeh, Fereshteh Bahmani, Abbas Mohtashamian, Armin Ebrahimzadeh, Nasrin Sharifi   +7 more
doaj   +1 more source

Detoxification of Fumonisins by Three Novel Transaminases with Diverse Enzymatic Characteristics Coupled with Carboxylesterase

Foods, 2023
Fumonisin (FB) is one of the most common mycotoxins contaminating feed and food, causing severe public health threat to human and animals worldwide.
Yue Wang, Jun-mao Sun, Mengwei Zhang, Kungang Pan, Tianhui Liu, Tongcun Zhang, Xuegang Luo, Junqi Zhao, Zhongyuan Li   +8 more
semanticscholar   +1 more source