Results 41 to 50 of about 10,864 (249)

CASCAT: Redesign of omega-Transaminases for Synthesis of Chiral Amines☆

, 2010
Transaminases (EC 2.6.1.18) are attractive biocatalysts for synthesis of chiral amines and alpha-amino acids. These enzymes catalyze transfer of an amine group from a donor substrate to an acceptor compound using the cofactor pyridoxal-5′-phoshate (PLP).
Engelmark Cassimjee, Karim,, V. Abedi, Svedendahl, Maria,, Branneby, C., C. Branneby, K.E. Cassimjee, P. Berglund, M. Svedendahl, Berglund, Per,, Wells, A., Abedi, V., A. Wells   +11 more
core   +1 more source

Real‐World Longitudinal Data on the Impact of Hydroxychloroquine Blood Level Monitoring on Lupus Outcomes: Results of a Prospective Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel, Fauzia Hollangel, Caroline Packee, Amita Kapoor, Brad Rovin, Nathalie Costedoat‐Chalumeau, Shivani Garg   +6 more
wiley   +1 more source

Protective effect of garlic on methyl ethyl ketone-induced biochemical changes in male rabbits. [PDF]

Journal of Bioscience and Applied Research, 2016
The present study evaluated the effect of inhalation of methyl ethyl ketone (MEK) on biochemical parameters of rabbits and the possible protective role of garlic aqueous extract. Animals were divided into 4 groups.
Zuhair Y. Al-Sahhaf
doaj   +1 more source

The Effects of the Combination of Buckwheat D-Fagomine and Fish Omega-3 Fatty Acids on Oxidative Stress and Related Risk Factors in Pre-Obese Rats

Foods, 2021
The combined supplementation of buckwheat D-fagomine (FG) and fish omega-3 polyunsaturated fatty acids (ω-3 PUFA) attenuates the development of insulin resistance in rats fed a high-fat (HF) diet.
Bernat Miralles-Pérez, Maria Rosa Nogués, Vanessa Sánchez-Martos, Núria Taltavull, Lucía Méndez, Isabel Medina, Sara Ramos-Romero, Josep L. Torres, Marta Romeu   +8 more
doaj   +1 more source

Deracemization of Mexiletine Biocatalyzed by ω-Transaminases

, 2016
(S)- as well as (R)-mexiletine [1-(2,6-dimethylphenoxy)-2-propanamine], a chiral orally effective antiarrhythmic agent, was prepared by deracemization starting from the commercially available racemic amine using ω-transaminases in up to >99% ee and ...
Wolfgang Kroutil (1279629), Desiree Pressnitz (1446190), Dominik Koszelewski (1285221), Dorina Clay (1292898)   +3 more
core   +1 more source

Impact of Six‐Month Monitoring Compared to Three‐Month Monitoring of Laboratories During Methotrexate Therapy

Arthritis Care &Research, EarlyView.
Objective To evaluate whether extending the American College of Rheumatology–recommended monitoring interval for complete blood count and liver function tests in patients receiving methotrexate (MTX) affects timely detection of medication‐related toxicity.
Spencer Simko, Ray Zhang, Sohini Mukherjee, Puneet Bajaj, Bonnie L. Bermas   +4 more
wiley   +1 more source

Amine Transaminases in Multi-Step One-Pot Reactions

, 2017
Amine transaminases are enzymes that catalyze the mild and selective formation of primary amines, which are useful building blocks for biologically active compounds and natural products.
Anderson, Mattias
core   +2 more sources

Effect of High Dietary Level (8%) of Fish Oil on Long-Chain Polyunsaturated Fatty Acid n-3 Content in Pig Tissues and Plasma Biochemical Parameters

Animals, 2020
There were two objectives of the present study using dietary fish oil (FO) in pigs: to use pigs as a model for studying the effects of high FO doses on selected physiological markers; and to evaluate the physical traits and nutritive value of pork ...
Tomas Komprda, Miroslav Jůzl, Milena Matejovičová, Lenka Levá, Markéta Piechowiczová, Šárka Nedomová, Vendula Popelková, Pavla Vymazalová   +7 more
doaj   +1 more source

Elevated Liver Enzymes Is Not an Impediment to Allopurinol Dose Escalation: An Observational Cohort Study

Arthritis Care &Research, EarlyView.
Objective Routine liver enzyme monitoring is advocated for while on allopurinol, but supporting guidance is lacking. We assessed the incidence and factors associated with elevated liver enzyme levels in patients with gout commenced on allopurinol. Methods One hundred and fifty patients with gout and normal baseline serum aminotransferases initiated on ...
May Shuen Tang, Qai Ven Yap, Peter Pak Moon Cheung, Amelia Santosa, Gim Gee Teng   +4 more
wiley   +1 more source

Cirrosis biliar primaria: patología subdiagnosticada. Reporte de caso

Revista Médica Hondureña
Introduction: Primary biliary cirrhosis is a chronic, cholestatic, autoimmune, and progressive liver disease that pre-dominantly affects women.
Delmy Saraí Castillo Álvarez, Alejandra María Sosa, Diana Magoe Meza   +2 more
doaj   +1 more source