Results 21 to 30 of about 46,144 (173)

Phosphoserine aminotransferase 1 promotes serine synthesis pathway and cardiac repair after myocardial infarction. [PDF]

Theranostics
Background and Purpose: The permanent loss of cardiomyocytes (CMs) following myocardial infarction (MI), coupled with the heart's limited regenerative capacity, often leads to heart failure. Phosphoserine aminotransferase 1 (PSAT1) is a protein highly expressed in the embryonic mouse heart but markedly downregulated after birth. Despite its presence in
Magadum A, Mallaredy V, Roy R, Joladarashi D, Thej C, Cheng Z, Cimini M, Truongcao M, Chatoff A, Crispim CV, Rigaud VOC, Gonzalez C, Benedict C, Santos CXC, Snyder NW, Khan M, Shah AM, Koch WJ, Kishore R.   +18 more
europepmc   +3 more sources

Hydrocortisone interacts with endoplasmic reticulum stress in hypoxic regulation of phosphoserine aminotransferase 1 gene expression differently in normal human astrocytes and glioblastoma cells

Endocrine Regulations
Objective. Endoplasmic reticulum (ER) stress and hypoxia are key factors for the effective growth of malignant tumors, including glioblastoma. The phosphoserine aminotransferase 1 (PSAT1) is an ER stress-responsive enzyme responsible for serine synthesis
Minchenko Oleksandr H., Abramchuk Anastasiia I., Khikhlo Yevgen P., Sliusar Myroslava Y., Halkin Oleh V., Luzina Olha Y., Danilovsryi Serhiy V., Viletska Yuliia M., Minchenko Dmytro O.   +8 more
doaj   +2 more sources

Protein post-translational modifications in serine synthetic pathway: functions and molecular mechanisms [PDF]

Cell Communication and Signaling
Serine is a non-essential amino acid, serving as a precursor for other amino acids, lipids, and nucleotide synthesis. Its supply is ensured by two main mechanisms: exogenous uptake and endogenous synthesis.
Mincong Shu, Yuhan Liu, Jianbin Wang
doaj   +2 more sources

Strain relief at the active site of phosphoserine aminotransferase induced by radiation damage. [PDF]

Protein Sci, 2005
AbstractThe X‐ray susceptibility of the lysine‐pyridoxal‐5′‐phosphate Schiff base in Bacillus alcalophilus phosphoserine aminotransferase has been investigated using crystallographic data collected at 100 K to 1.3 Å resolution, complemented by on‐line spectroscopic studies.
Dubnovitsky AP, Ravelli RB, Popov AN, Papageorgiou AC.   +3 more
europepmc   +4 more sources

Dietary sulfur amino acid restriction improves glucose homeostasis through hepatic de novo serine synthesis [PDF]

Molecular Metabolism
Dietary sulfur amino acid restriction (SAAR) improves whole-body glucose homeostasis, elevates liver insulin action, and lowers liver triglycerides. These adaptations are associated with an increased expression of hepatic de novo serine synthesis enzymes,
Andres F. Ortega, Cha Mee Vang, Ferrol I. Rome, Kaitlyn M. Andreoni, Aiden M. Phoebe, Alisa B. Nelson, Peter A. Crawford, James J. Galligan, Stanley Ching-Cheng Huang, Curtis C. Hughey   +9 more
doaj   +2 more sources

Overexpression of Phosphoserine Aminotransferase 1 (PSAT1) Predicts Poor Prognosis and Associates with Tumor Progression in Human Esophageal Squamous Cell Carcinoma

Cellular Physiology and Biochemistry, 2016
Background/Aims: Phosphoserine aminotransferase 1 (PSAT1) is over-expressed in many carcinoma tissues, however little is known regarding its expression and function in esophageal carcinogenesis.
Bingyan Liu, Yiping Jia, Yan Cao, Shaoqiu Wu, Haosheng Jiang, Xianjun Sun, Jun Ma, Xiang Yin, Aiwu Mao, Mingyi Shang   +9 more
doaj   +2 more sources

Phosphoserine Aminotransferase [PDF]

, 2020
openaire   +2 more sources

Over-Expression of Phosphoserine Aminotransferase-Encoding Gene (AtPSAT1) Prompts Starch Accumulation in L. turionifera under Nitrogen Starvation. [PDF]

Int J Mol Sci, 2022
It has been demonstrated that the phosphorylation pathway of L-serine (Ser) biosynthesis (PPSB) is very important in plant growth and development, but whether and how PPSB affects nitrogen metabolism and starch accumulation has not been fully elucidated.
Wang L, Li S, Sun L, Tong Y, Yang L, Zhu Y, Wang Y.   +6 more
europepmc   +2 more sources

Investigation of phosphoserine aminotransferase 1(PSAT1) in breast cancer progression. [PDF]

, 2020
This dissertation describes my research into the involvement of phosphoserine aminotransferase 1 (PSAT1) in breast cancer progression; specifically, in triple negative breast cancer (TNBC) metastasis and endocrine resistance in estrogen receptor positive
Metcalf, Stephanie
openaire   +3 more sources

ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction

Cell Reports, 2021
Summary: The serine synthesis pathway (SSP) involving metabolic enzymes phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1), and phosphoserine phosphatase (PSPH) drives intracellular serine biosynthesis and is indispensable ...
Xingyao Li, Daniel Gracilla, Lun Cai, Mingyi Zhang, Xiaolin Yu, Xiaoguang Chen, Junran Zhang, Xiaochun Long, Han-Fei Ding, Chunhong Yan   +9 more
doaj   +1 more source