Cellular Physiology and Biochemistry, 2016 Background/Aims: Phosphoserine aminotransferase 1 (PSAT1) is over-expressed in many carcinoma tissues, however little is known regarding its expression and function in esophageal carcinogenesis.
Bingyan Liu +9 more
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Phosphoserine aminotransferase deficiency: a novel disorder of the serine biosynthesis pathway. [PDF]
Am J Hum Genet, 2007 We present the first two identified cases of phosphoserine aminotransferase deficiency. This disorder of serine biosynthesis has been identified in two siblings who showed low concentrations of serine and glycine in plasma and cerebrospinal fluid. Clinically, the index patient presented with intractable seizures, acquired microcephaly, hypertonia, and ...
Hart CE +10 more
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Cancer-associated Fibroblast-like Cells Promote Osteosarcoma Metastasis by Upregulation of Phosphoserine Aminotransferase 1 and Activation of the mTOR/S6K Pathway. [PDF]
Int J Biol SciMetastasis remains a major obstacle limiting the survival of patients with osteosarcoma (OS). Cross-talk between cancer-associated fibroblasts (CAFs) and OS cells has been found to facilitate metastasis, although the effects of CAFs on OS cell metabolism
Feng L +10 more
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Phosphoserine Aminotransferase [PDF]
Definitions, 2020 Phosphoserine aminotransferase (370 aa, ~40 kDa) is encoded by the human PSAT1 gene. This protein is involved in amino acid biosynthesis.
semanticscholar +2 more sources
Structural basis of
Acta Crystallographica Section D Biological Crystallography, 2013 Phosphoserine aminotransferase is a vitamin B6-dependent enzyme that catalyzes the reversible conversion of 3-phosphohydroxypyruvate to L-phosphoserine using glutamate as an amine donor. In an effort to gain insight into the substrate-recognition mechanism of the enzyme, crystal structures of Bacillus alcalophilus phosphoserine aminotransferase in the ...
Battula, Pradeep +2 more
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Investigation of phosphoserine aminotransferase 1(PSAT1) in breast cancer progression. [PDF]
, 2019 This dissertation describes my research into the involvement of phosphoserine aminotransferase 1 (PSAT1) in breast cancer progression; specifically, in triple negative breast cancer (TNBC) metastasis and endocrine resistance in estrogen receptor positive
Stephanie Metcalf
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Phosphoserine aminotransferase deficiency [PDF]
Definitions, 2020 Ope n Pe e r Re v ie w on Qe ios Ope n Pe e r Re v ie w on Qe ios Phosphoserine aminotransferase ...
Inserm
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Phosphoserine Aminotransferase1 Is Part of the Phosphorylated Pathways for Serine Biosynthesis and Essential for Light and Sugar-Dependent Growth Promotion [PDF]
Frontiers in Plant Science, 2018 The phosphorylated pathway of serine biosynthesis represents an important pathway in plants. The pathway consist of three reactions catalyzed by the phosphoglycerate dehydrogenase, the phosphoserine aminotransferase and the phosphoserine phosphatase, and
Sabine Wulfert, Stephan Krueger
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Endocrine Regulations, 2023 Objective. Serine synthesis as well as endoplasmic reticulum stress and hypoxia are important factors of malignant tumor growth including glioblastoma.
Sliusar Myroslava Y. +8 more
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Downregulation of Phosphoserine aminotransferase 1 promotes tumorigenesis in Glioblastoma
The FASEB Journal, 2020 Glioblastoma (GBM) is a typical brain tumor with survival below ten percent at 5 years after diagnosis. The genetic alternation and histological features are integrated into the classification of gliomas for better clinical management of GBM.
Yung-Chieh Chan +3 more
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