Results 41 to 50 of about 163,724 (193)

[179] Phosphoserine aminotransferase (sheep brain)

Archives of Biochemistry and Biophysics, 1971
Publisher Summary This chapter focuses on Phosphoserine Aminotransferase (Sheep Brain). The chapter begins with a discussion of Assay method. Phosphohydroxypyruvate is prepared by hydrolysis of the hydroxypyruvic acid phosphate dimethylketal according to the procedure of Ballou.
Helga Hirsch-Kolb, David M. Greenberg
  +7 more sources

Altered expression of genes involved in the serine synthesis pathway (SSP) in patients with acute myeloid leukemia [PDF]

Journal of Kerman University of Medical Sciences
Background: Acute myeloid leukemia (AML) is characterized by the uncontrolled proliferation of malignant cells, which rely on various metabolic pathways to sustain their survival and growth.
Parinaz Khadem, Ali Keshavarz, Mohammad Hossein Mohammadi, Fateme Mezginejad, Mehdi Allahbakhshian Farsani   +4 more
doaj   +1 more source

Studies on Phosphoserine Aminotransferase of Sheep Brain

Journal of Biological Chemistry, 1967
Abstract Phosphoserine aminotransferase has been purified about 500-fold from sheep brain extracts by ammonium sulfate precipitation and Sephadex and diethylaminoethyl cellulose chromatography. On ultracentrifugation, the enzyme migrated in a single peak with a sedimentation constant of 4.2 S.
H, Hirsch, D M, Greenberg
openaire   +2 more sources

Targeting the Serine Pathway: A Promising Approach against Tuberculosis?

Pharmaceuticals, 2019
Tuberculosis is still the leading cause of death by a single infectious agent. Effective chemotherapy has been used and improved since the 1950s, but strains resistant to this therapy and most antibacterial drugs on the market are emerging.
Marie Haufroid, Johan Wouters
doaj   +1 more source

Strain relief at the active site of phosphoserine aminotransferase induced by radiation damage [PDF]

Protein Science, 2005
AbstractThe X‐ray susceptibility of the lysine‐pyridoxal‐5′‐phosphate Schiff base in Bacillus alcalophilus phosphoserine aminotransferase has been investigated using crystallographic data collected at 100 K to 1.3 Å resolution, complemented by on‐line spectroscopic studies.
Anatoly P, Dubnovitsky, Raimond B G, Ravelli, Alexander N, Popov, Anastassios C, Papageorgiou   +3 more
openaire   +2 more sources

Stabilization of Notch1 and β-catenin in response to ER- breast cancer-specific up-regulation of PSAT1 mediates distant metastasis

Translational Oncology, 2022
Breast cancer has the highest incidence in women worldwide, with a mortality rate second only to lung cancer. Distant metastasis is the major cause of breast cancer-induced death.
Shuxuan Zhu, Xiaoyu Wang, Lei Liu, Guosheng Ren   +3 more
doaj   +1 more source

AMPK-HIF-1α signaling enhances glucose-derived de novo serine biosynthesis to promote glioblastoma growth

Journal of Experimental & Clinical Cancer Research, 2023
Background Cancer cells undergo cellular adaptation through metabolic reprogramming to sustain survival and rapid growth under various stress conditions. However, how brain tumors modulate their metabolic flexibility in the naturally serine/glycine (S/G)-
Hye Jin Yun, Min Li, Dong Guo, So Mi Jeon, Su Hwan Park, Je Sun Lim, Su Bin Lee, Rui Liu, Linyong Du, Seok-Ho Kim, Tae Hwan Shin, Seong-il Eyun, Yun-Yong Park, Zhimin Lu, Jong-Ho Lee   +14 more
doaj   +1 more source

Comparison of kinetic and enzymatic properties of intracellular phosphoserine aminotransferases from alkaliphilic and neutralophilic bacteria

Open Chemistry, 2020
Intracellular pyridoxal 5´-phosphate (PLP) -dependent recombinant phosphoserine aminotransferases (PSATs; EC 2.6.1.52) from two alkaliphilic Bacillus strains were overproduced in Escherichia coli, purified to homogeneity and their enzymological ...
Koivulehto Marianne, Battchikova Natalia, Korpela Saara, Khalikova Elvira, Zavialov Anton, Korpela Timo   +5 more
doaj   +1 more source

Characterization of human phosphoserine aminotransferase involved in the phosphorylated pathway of l-serine biosynthesis [PDF]

Biochemical Journal, 2003
In the present study, we first report two forms of human phosphoserine aminotransferase (PSAT) cDNA (HsPSATα and HsPSATβ). HsPSATα has a predicted open reading frame comprising 324 amino acids, encoding a 35.2 kDa protein (PSATα), whereas HsPSATβ consists of an open reading frame comprising 370 amino acids that encodes a 40 kDa protein (PSATβ).
Joo Youn, Baek, Do Youn, Jun, Dennis, Taub, Young Ho, Kim   +3 more
openaire   +2 more sources

Structural Analysis of a Putative Phosphoserine Aminotransferase from C.Hutchinsonii

, 2015
Structural analysis results for a putative phosphoserine aminotransferase from Cytophaga Hutchinsonii. 
Saman Ehsan (645533)
core   +1 more source