Results 41 to 50 of about 46,144 (173)

Stabilization of Notch1 and β-catenin in response to ER- breast cancer-specific up-regulation of PSAT1 mediates distant metastasis

Translational Oncology, 2022
Breast cancer has the highest incidence in women worldwide, with a mortality rate second only to lung cancer. Distant metastasis is the major cause of breast cancer-induced death.
Shuxuan Zhu, Xiaoyu Wang, Lei Liu, Guosheng Ren   +3 more
doaj   +1 more source

Amino Acid and Lipid Metabolism in Cancer: Mechanisms and Therapeutic Opportunities. [PDF]

MedComm (2020)
Amino Acid and lipid metabolism in cancer: (A) Regulation of Amino acid transportation and metabolism in cancer. (B) The core organization of lipid metabolic reprogramming in cancer and their functional consequences. ABSTRACT Metabolic reprogramming is a defining feature of cancer and a major contributor to immune escape.
Wang Z, Fu X, Bai J, Liu Y, Huang K.
europepmc   +2 more sources

AMPK-HIF-1α signaling enhances glucose-derived de novo serine biosynthesis to promote glioblastoma growth

Journal of Experimental & Clinical Cancer Research, 2023
Background Cancer cells undergo cellular adaptation through metabolic reprogramming to sustain survival and rapid growth under various stress conditions. However, how brain tumors modulate their metabolic flexibility in the naturally serine/glycine (S/G)-
Hye Jin Yun, Min Li, Dong Guo, So Mi Jeon, Su Hwan Park, Je Sun Lim, Su Bin Lee, Rui Liu, Linyong Du, Seok-Ho Kim, Tae Hwan Shin, Seong-il Eyun, Yun-Yong Park, Zhimin Lu, Jong-Ho Lee   +14 more
doaj   +1 more source

Alanine Aminotransferase, gamma-Glutamyltransferase, and Incident Diabetes [PDF]

, 2009
OBJECTIVE - To estimate and compare associations of alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) with incident diabetes. RESEARCH DESIGN AND METHODS - ALT and GGT were studied as determinants of diabetes in the British Women's ...
Ebrahim, Shah B J, Harris, R, Harris, Ross, Lawlor, D, Sattar, N, Sattar, Naveed, Ebrahim, S, Lawlor, Debbie A, Lawlor, DA, Fraser, Abigail, Davey Smith, George, Harris, RJ, Fraser, A, Davey Smith, G, Ebrahim, Shah, Sattar, NA   +15 more
core   +1 more source

Comparison of kinetic and enzymatic properties of intracellular phosphoserine aminotransferases from alkaliphilic and neutralophilic bacteria

Open Chemistry, 2020
Intracellular pyridoxal 5´-phosphate (PLP) -dependent recombinant phosphoserine aminotransferases (PSATs; EC 2.6.1.52) from two alkaliphilic Bacillus strains were overproduced in Escherichia coli, purified to homogeneity and their enzymological ...
Koivulehto Marianne, Battchikova Natalia, Korpela Saara, Khalikova Elvira, Zavialov Anton, Korpela Timo   +5 more
doaj   +1 more source

Characterization of human phosphoserine aminotransferase involved in the phosphorylated pathway of l-serine biosynthesis [PDF]

Biochemical Journal, 2003
In the present study, we first report two forms of human phosphoserine aminotransferase (PSAT) cDNA (HsPSATα and HsPSATβ). HsPSATα has a predicted open reading frame comprising 324 amino acids, encoding a 35.2 kDa protein (PSATα), whereas HsPSATβ consists of an open reading frame comprising 370 amino acids that encodes a 40 kDa protein (PSATβ).
Joo Youn, Baek, Do Youn, Jun, Dennis, Taub, Young Ho, Kim   +3 more
openaire   +2 more sources

Chromatin Structures of the Rat Tyrosine Aminotransferase Gene Relate to the Function of Its cis-Acting Elements [PDF]

, 1990
The relationship between DNase I-hypersensitive sites (HSs) and transcriptional enhancers of the rat tyrosine aminotransferase (TAT) gene was examined by comparing HSs in and around the TAT gene with the activity of the corresponding DNA sequences in ...
Boshart, Michael, Schütz, Günther, Nitsch, Doris, Mestril, Ruben, Weih, Falk, Stewart, A. F.   +5 more
core   +1 more source

Structural Analysis of a Putative Phosphoserine Aminotransferase from C.Hutchinsonii

, 2015
Structural analysis results for a putative phosphoserine aminotransferase from Cytophaga Hutchinsonii. 
Saman Ehsan (645533)
core   +1 more source

RNA-Seq of Phenotypically Distinct Eimeria maxima Strains Reveals Coordinated and Contrasting Maturation and Shared Sporogonic Biomarkers with Eimeria acervulina

Pathogens, 2023
Strains of Eimeria maxima, an enteric parasite of poultry, vary in virulence. Here, we performed microscopy and RNA sequencing on oocysts of strains APU-1 (which exhibits more virulence) and APU-2.
Matthew S. Tucker, Celia N. O’Brien, Alexis N. Johnson, Jitender P. Dubey, Benjamin M. Rosenthal, Mark C. Jenkins   +5 more
doaj   +1 more source

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source