Results 61 to 70 of about 163,724 (193)

SARS-CoV-2 and Glutamine: SARS-CoV-2 Triggered Pathogenesis via Metabolic Reprograming of Glutamine in Host Cells

Frontiers in Molecular Biosciences, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, as coronavirus disease 2019 (COVID-19) pandemic, has killed more than a million people worldwide, and researchers are constantly working to develop therapeutics in the treatment and ...
Shiv Bharadwaj, Mahendra Singh, Nikhil Kirtipal, Sang Gu Kang   +3 more
doaj   +1 more source

Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells-1

, 2011
Copyright information:Taken from "Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells"http://www.molecular-cancer.com/content/7/1/14Molecular Cancer 2008;7():14-14.Published ...
Céline Gongora (86934), Emmanuel Conseiller (86931), Caroline Fraslon (86930), Vincent Denis (86928), Virginie Copois (86926), Nicole Bec (86678), Caroline Bascoul-Mollevi (86927), Franck Molina (86932), Bruno Robert (86929), Pierre Martineau (6238), Maguy Del Rio (86933), Christian Larroque (86679), Nadia Vié (86925)   +12 more
core   +1 more source

Advances in Immunological Combination Therapy for Colorectal Cancer

iMetaMed, Volume 2, Issue 3, September 2026.
Review the progress of combined immunotherapy for colorectal cancer. ABSTRACT Immune checkpoint inhibitors (ICIs) have been utilized extensively and shown to be therapeutically beneficial in the treatment of solid tumors in recent years. Nonetheless, considerable heterogeneity in Colorectal cancer (CRC) requires careful consideration.
Jiayue Wu, Rongbo Wen, Tianshuai Zhang, Fuao Cao, Xiaoming Zhu, Liqiang Hao, Wei Zhang, Guanyu Yu   +7 more
wiley   +1 more source

Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells-2

, 2011
Copyright information:Taken from "Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells"http://www.molecular-cancer.com/content/7/1/14Molecular Cancer 2008;7():14-14.Published ...
Céline Gongora (86934), Emmanuel Conseiller (86931), Caroline Fraslon (86930), Vincent Denis (86928), Virginie Copois (86926), Nicole Bec (86678), Caroline Bascoul-Mollevi (86927), Franck Molina (86932), Bruno Robert (86929), Pierre Martineau (6238), Maguy Del Rio (86933), Christian Larroque (86679), Nadia Vié (86925)   +12 more
core   +1 more source

Human Cerebral Cortex Proteome of Fragile X-Associated Tremor/Ataxia Syndrome

Frontiers in Molecular Biosciences, 2021
Background: Fragile X-associated tremor/ataxia syndrome (FXTAS) is an adult-onset neurodegenerative disorder associated with premutation CGG-repeat expansions (55–200 repeats) in the 5′ non-coding portion of the fragile X mental retardation 1 (FMR1) gene.
Katharine Nichole Holm, Anthony W. Herren, Sandra L. Taylor, Jamie L. Randol, Kyoungmi Kim, Kyoungmi Kim, Glenda Espinal, Verónica Martínez-Cerdeño, Verónica Martínez-Cerdeño, Isaac N. Pessah, Isaac N. Pessah, Randi J. Hagerman, Randi J. Hagerman, Paul J. Hagerman, Paul J. Hagerman   +14 more
doaj   +1 more source

Cooperativity of Glucocorticoid Response Elements Located Far Upstream of the Tyrosine Aminotransferase Gene [PDF]

, 1987
Two glucocorticoid response elements (GREs) located 2.5 kb upstream of the transcription initiation site of the tyrosine aminotransferase gene were identified by gene transfer experiments and shown to bind to purified glucocorticoid receptor.
Strähle, Uwe, Boshart, Michael, Schmid, Wolfgang, Miksicek, Richard, Jansen, Hans-Michael, Gloss, Bernd, Schlitz, Günther, Stewart, Francis   +7 more
core   +1 more source

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, Volume 13, Issue 47, 24 August 2026.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Rethinking the evolution of eukaryotic metabolism: novel cellular partitioning of enzymes in stramenopiles links serine biosynthesis to glycolysis in mitochondria

BMC Evolutionary Biology, 2017
Background An important feature of eukaryotic evolution is metabolic compartmentalization, in which certain pathways are restricted to the cytosol or specific organelles. Glycolysis in eukaryotes is described as a cytosolic process.
Melania Abrahamian, Meenakshi Kagda, Audrey M. V. Ah-Fong, Howard S. Judelson   +3 more
doaj   +1 more source

Pathogenesis of Tuberculosis: Interplay Between Host Antituberculosis Immunity and Immune Evasion Strategies of Mycobacterium Tuberculosis

MedComm, Volume 7, Issue 8, August 2026.
Mycobacterium tuberculosis–host interactions and infection outcomes. Following initial infection, alveolar macrophages phagocytose the pathogen, prompting the recruitment of innate immune cells including neutrophils, NK cells, and interstitial macrophages.
Xiaojuan Zhang, Ying Liu, Yilin Hou, Hongxia Niu   +3 more
wiley   +1 more source

Image_1_Structural Analysis of Phosphoserine Aminotransferase (Isoform 1) From Arabidopsis thaliana– the Enzyme Involved in the Phosphorylated Pathway of Serine Biosynthesis.PDF

, 2018
Phosphoserine aminotransferase (PSAT) is a pyridoxal 5′-phosphate (PLP)-dependent enzyme that catalyzes the conversion of 3-phosphohydroxypyruvate (3-PHP) to 3-phosphoserine (PSer) in an L-glutamate (Glu)-linked reversible transamination reaction.
Milosz Ruszkowski (5206202), Bartosz Sekula (1434751), Zbigniew Dauter (588077)   +2 more
core   +1 more source