Results 71 to 80 of about 163,724 (193)

Cysteine biosynthesis in trichomonas vaginalis involves cysteine synthase utilizing o-phosphoserine

, 2006
Trichomonas vaginalis is an early divergent eukaryote with many unusual biochemical features. It is an anaerobic protozoan parasite of humans that is thought to rely heavily on cysteine as a major redox buffer, because it lacks glutathione.
Coombs, G.H., Goodall, Gordon, Westrop, G.D., Mottram, Jeremy C.   +3 more
core   +3 more sources

Amino Acid and Lipid Metabolism in Cancer: Mechanisms and Therapeutic Opportunities

MedComm, Volume 7, Issue 8, August 2026.
Amino Acid and lipid metabolism in cancer: (A) Regulation of Amino acid transportation and metabolism in cancer. (B) The core organization of lipid metabolic reprogramming in cancer and their functional consequences. ABSTRACT Metabolic reprogramming is a defining feature of cancer and a major contributor to immune escape.
Zixu Wang, Xin Fu, Jingchao Bai, Yanguo Liu, Kai Huang   +4 more
wiley   +1 more source

Aryloxy Triester Phosphoramidates as Phosphoserine Prodrugs: A Proof of Concept Study [PDF]

, 2020
The specific targeting of protein‐protein interactions by phosphoserine‐containing small molecules has been scarce due to the dephosphorylation of phosphoserine and its charged nature at physiological pH, which hinder its uptake into cells.
Hachemi Kadri, Mehellou, Youcef, Peter J. Thornton, Kadri, Hachemi, Edward James, Youcef Mehellou, Thornton, Peter J., James, Edward, Dhiani, Binar A., Olivia A. Lambourne, Dhiani, Binar, Lambourne, Olivia, Ageo Miccoli, Miccoli, Ageo, Lambourne, Olivia A., Thornton, Peter, Binar A. Dhiani   +16 more
core   +1 more source

Relationship Between Central Sensitization and Genetic Polymorphisms—A Case–Control Study in Fibromyalgia

European Journal of Pain, Volume 30, Issue 6, July 2026.
ABSTRACT Background Fibromyalgia is a syndrome characterised by widespread chronic pain, which is believed to be mediated by a state of central sensitisation (CS). Based on the hypothesis that CS itself could have genetic determinants, our aim was to further explore this pathway.
Nicolas Macian, Christian Dualé, Marine Delay, Vincent Leray, Bruno Pereira, Yoan Renaud, Yvonne Gloor, Jules Desmeules, Gisèle Pickering   +8 more
wiley   +1 more source

Application of Bioactive Thermal Proteome Profiling to Decipher the Mechanism of Action of the Lipid Lowering 13²-Hydroxy-pheophytin Isolated from a Marine Cyanobacteria

Marine Drugs, 2019
The acceleration of the process of understanding the pharmacological application of new marine bioactive compounds requires identifying the compound protein targets leading the molecular mechanisms in a living cell.
Ana Carrasco del Amor, Sara Freitas, Ralph Urbatzka, Olatz Fresnedo, Susana Cristobal   +4 more
doaj   +1 more source

Hepatic Phosphoserine Aminotransferase 1 Regulates Insulin Sensitivity in Mice via Tribbles Homolog 3 [PDF]

Diabetes, 2014
Phosphoserine aminotransferase 1 (PSAT1) is an enzyme participating in serine synthesis. A role of PSAT1 in the regulation of insulin sensitivity, however, is unknown. In this study, we showed that hepatic PSAT1 expression and liver serine levels are reduced in genetically engineered leptin receptor–deficient (db/db) mice and high-fat diet (HFD ...
Junjie, Yu, Fei, Xiao, Yajie, Guo, Jiali, Deng, Bin, Liu, Qian, Zhang, Kai, Li, Chunxia, Wang, Shanghai, Chen, Feifan, Guo   +9 more
openaire   +2 more sources

Branched‐Chain Amino and Keto Acids Reduce Hepatocyte Lipid Droplet Size and Number via Distinct Proteomic Pathways

PROTEOMICS, Volume 26, Issue 7, Page 146-157, July 2026.
ABSTRACT Branched‐chain amino acids (BCAA) and their corresponding keto acids (BCKA) have been associated with changes in hepatic lipid metabolism and the resulting alterations in intracellular triglyceride concentrations. In this study, we utilized a previously established hepatocyte model to investigate the impact of BCAA and BCKA supplementation on ...
Jayasimha R. Daddam, Mounica Sura, Edward Kolodziej, Maria Gojcaj, Zheng Zhou   +4 more
wiley   +1 more source

The phosphoenolpyruvate carboxykinase (PEPCK) inhibitor, 3-mercaptopicolinic acid (3-MPA), induces myogenic differentiation in C2C12 cells

Scientific Reports, 2020
Phosphoenolpyruvate carboxykinase (PEPCK) is a gluconeogenic enzyme with a cytosolic (Pck1/PEPCK-C) and mitochondrial (Pck2/PEPCK-M) isoform. Here we investigate the effect of 3-mercaptopicolinic acid (3-MPA), a PEPCK inhibitor, on C2C12 muscle cells. We
Madelaine C. Brearley, Zoe C. T. R. Daniel, Paul T. Loughna, Tim Parr, John M. Brameld   +4 more
doaj   +1 more source

Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma

eFood, Volume 7, Issue 3, June 2026.
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie, Wei Fang, Zean Song, Zhang Yu, Ying Zhu, Shaoping Liu   +5 more
wiley   +1 more source

Changes in expression of serine biosynthesis and integrated stress response genes during myogenic differentiation of C2C12 cells

Biochemistry and Biophysics Reports, 2019
Skeletal muscle is a highly metabolic and dynamic tissue that is formed through the complex and well-organised process of myogenesis. Although there is a good understanding about the role of the Muscle Regulatory Factors during myogenesis, little is ...
Madelaine C. Brearley, Congcong Li, Zoe C.T.R. Daniel, Paul T. Loughna, Tim Parr, John M. Brameld   +5 more
doaj   +1 more source