Results 71 to 80 of about 3,020 (150)

Interplay between acetylation and ubiquitination controls PSAT1 protein stability in lung adenocarcinoma

Communications Biology
Serine is essential to maintain maximal growth and proliferation of cancer cells by providing adequate intermediate metabolites and energy. Phosphoserine aminotransferase 1 (PSAT1) is a key enzyme in de novo serine synthesis.
Yuhan Liu, Wenze Xun, Tao Zhao, Menglin Huang, Longhua Sun, Guilan Wen, Xiuhua Kang, Jianbin Wang, Tianyu Han   +8 more
doaj   +1 more source

PSAT1 is upregulated by METTL3 to attenuate high glucose-induced retinal pigment epithelial cell apoptosis and oxidative stress

Diagnostic Pathology
Background Diabetic retinopathy (DR) is a major ocular complication of diabetes mellitus, and a significant cause of visual impairment and blindness in adults. Phosphoserine aminotransferase 1 (PSAT1) is an enzyme participating in serine synthesis, which
Xiaofeng Du, Yanting Wang, Fan Gao
doaj   +1 more source

Natural Variation in SER1 and ENA6 Underlie Condition-Specific Growth Defects in Saccharomyces cerevisiae

G3: Genes, Genomes, Genetics, 2018
Despite their ubiquitous use in laboratory strains, naturally occurring loss-of-function mutations in genes encoding core metabolic enzymes are relatively rare in wild isolates of Saccharomyces cerevisiae.
Amy Sirr, Adrian C. Scott, Gareth A. Cromie, Catherine L. Ludlow, Vida Ahyong, Trey S. Morgan, Teresa Gilbert, Aimée M. Dudley   +7 more
doaj   +1 more source

Abundance and functional diversity of riboswitches in microbial communities

BMC Genomics, 2007
Background Several recently completed large-scale enviromental sequencing projects produced a large amount of genetic information about microbial communities ('metagenomes') which is not biased towards cultured organisms.
Gelfand Mikhail S, Vitreschak Alexey G, Kazanov Marat D   +2 more
doaj   +1 more source

Overexpression of microRNA-195-5p reduces cisplatin resistance and angiogenesis in ovarian cancer by inhibiting the PSAT1-dependent GSK3β/β-catenin signaling pathway

Journal of Translational Medicine, 2019
Background Ovarian cancer (OC) is one of the leading causes for cancer-related deaths among women. MicroRNAs (miRs) have been proved to be vital to the development and progression of OC.
Jun Dai, Rujia Wei, Peihai Zhang, Beihua Kong   +3 more
doaj   +1 more source

ISEV2026 Abstract Book

Journal of Extracellular Vesicles, Volume 15, Issue S1, June 2026.
wiley   +1 more source

Over-Expression of Phosphoserine Aminotransferase-Encoding Gene (AtPSAT1) Prompts Starch Accumulation in L. turionifera under Nitrogen Starvation. [PDF]

Int J Mol Sci, 2022
Wang L, Li S, Sun L, Tong Y, Yang L, Zhu Y, Wang Y.   +6 more
europepmc   +1 more source

Phosphoserine aminotransferase deficiency in childhood ichthyosis with adolescent peripheral neuropathy caused by PSAT1 gene mutation: one case report

Chinese Journal of Contemporary Neurology and Neurosurgery, 2023
LI Ping, XU Yan‑fang, HU Shuai, ZENG Xiao‑xia, QI Xue‑liang   +4 more
doaj   +1 more source

PSAT1 regulates hair follicle growth and stem cell behavior in cashmere goats

BMC Veterinary Research
Background The Arbas Cashmere Goat from Inner Mongolia is renowned for its superior-quality cashmere, which is primarily produced by secondary hair follicles (SHFs).
Xiao-yu Han, Jia-ning Liu, Nan-xiang Sun, Yin-xian Zhang, Hao-bing Bai, Wei-guo Song, Xiao Hu, Hao Liang, Xiong Miao, Yun-mei He, Dong-jun Liu, Xu-dong Guo   +11 more
doaj   +1 more source

Serine starvation suppresses the progression of esophageal cancer by regulating the synthesis of purine nucleotides and NADPH

Cancer & Metabolism
Serine metabolism provides important metabolic intermediates that support the rapid proliferation of tumor cells. However, the role of serine metabolism in esophageal squamous cell carcinoma (ESCC) and the underlying mechanism remains unclear.
Hui Jie, Jing Wei, Zhuoling Li, Min Yi, Xinying Qian, Yan Li, Chunqi Liu, Chuan Li, Liang Wang, Pengchi Deng, Lunxu Liu, Xiaobo Cen, Yinglan Zhao   +12 more
doaj   +1 more source