Results 81 to 90 of about 46,144 (173)

Engineering and finetuning expression of SerC for balanced metabolic flux in vitamin B6 production

Synthetic and Systems Biotechnology
Vitamin B6 plays a crucial role in cellular metabolism and stress response, making it an essential component for growth in all known organisms. However, achieving efficient biosynthesis of vitamin B6 faces the challenge of maintaining a balanced ...
Kai Chen, Linxia Liu, Jinlong Li, Zhizhong Tian, Hongxing Jin, Dawei Zhang   +5 more
doaj   +1 more source

Abstract P1-01-15: Investigation of phosphoserine aminotransferase 1 and its role in breast cancer progression

, 2018
Metastasis and endocrine resistance are two factors that complicate therapeutic intervention in breast cancer patients and lead to poorer overall survival.
T Kruer, C Klinge, S Metcalf, B Clem
core   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source

Modulating the serine metabolism in human differentiated astrocytes: an integrated multi omics approach

Frontiers in Cellular Neuroscience
IntroductionAstrocytes are the major source of L-serine (L-Ser) in the brain: the glycolytic intermediate D-3-phosphoglycerate is converted into L-Ser through the phosphorylated pathway (PP) made up of three enzymes, phosphoglycerate dehydrogenase (PHGDH)
Farida Tripodi, Elisa Maffioli, Silvia Sacchi, Valentina Rabattoni, Zoraide Motta, Claudia Bearzi, Gabriella Tedeschi, Gabriella Tedeschi, Loredano Pollegioni, Paola Coccetti   +9 more
doaj   +1 more source

Comparison of odontogenic differentiation of human dental follicle cells and human dental papilla cells.

PLoS ONE, 2013
Classical tooth development theory suggests that dental papilla cells (DPCs) are the precursor cells of odontoblasts, which are responsible for dentin development.
Lijuan Guo, Jie Li, Xiangchen Qiao, Mei Yu, Wei Tang, Hang Wang, Weihua Guo, Weidong Tian   +7 more
doaj   +1 more source

Interplay between acetylation and ubiquitination controls PSAT1 protein stability in lung adenocarcinoma

Communications Biology
Serine is essential to maintain maximal growth and proliferation of cancer cells by providing adequate intermediate metabolites and energy. Phosphoserine aminotransferase 1 (PSAT1) is a key enzyme in de novo serine synthesis.
Yuhan Liu, Wenze Xun, Tao Zhao, Menglin Huang, Longhua Sun, Guilan Wen, Xiuhua Kang, Jianbin Wang, Tianyu Han   +8 more
doaj   +1 more source

Image_1_Structural Analysis of Phosphoserine Aminotransferase (Isoform 1) From Arabidopsis thaliana– the Enzyme Involved in the Phosphorylated Pathway of Serine Biosynthesis.PDF

, 2018
Phosphoserine aminotransferase (PSAT) is a pyridoxal 5′-phosphate (PLP)-dependent enzyme that catalyzes the conversion of 3-phosphohydroxypyruvate (3-PHP) to 3-phosphoserine (PSer) in an L-glutamate (Glu)-linked reversible transamination reaction.
Milosz Ruszkowski (5206202), Bartosz Sekula (1434751), Zbigniew Dauter (588077)   +2 more
core   +1 more source

PSAT1 is upregulated by METTL3 to attenuate high glucose-induced retinal pigment epithelial cell apoptosis and oxidative stress

Diagnostic Pathology
Background Diabetic retinopathy (DR) is a major ocular complication of diabetes mellitus, and a significant cause of visual impairment and blindness in adults. Phosphoserine aminotransferase 1 (PSAT1) is an enzyme participating in serine synthesis, which
Xiaofeng Du, Yanting Wang, Fan Gao
doaj   +1 more source

Natural Variation in SER1 and ENA6 Underlie Condition-Specific Growth Defects in Saccharomyces cerevisiae

G3: Genes, Genomes, Genetics, 2018
Despite their ubiquitous use in laboratory strains, naturally occurring loss-of-function mutations in genes encoding core metabolic enzymes are relatively rare in wild isolates of Saccharomyces cerevisiae.
Amy Sirr, Adrian C. Scott, Gareth A. Cromie, Catherine L. Ludlow, Vida Ahyong, Trey S. Morgan, Teresa Gilbert, Aimée M. Dudley   +7 more
doaj   +1 more source