A Novel Assay for Phosphoserine Phosphatase Exploiting Serine Acetyltransferase as the Coupling Enzyme [PDF]
Life, 2021 Phosphoserine phosphatase (PSP) catalyzes the final step of de novo L-serine biosynthesis—the hydrolysis of phosphoserine to serine and inorganic phosphate—in humans, bacteria, and plants.
Stefano Bettati +2 more
exaly +13 more sources
A morpheein equilibrium regulates catalysis in phosphoserine phosphatase SerB2 from Mycobacterium tuberculosis [PDF]
Communications Biology, 2023 Mycobacterium tuberculosis phosphoserine phosphatase MtSerB2 is of interest as a new antituberculosis target due to its essential metabolic role in L-serine biosynthesis and effector functions in infected cells.
Elise Pierson +3 more
doaj +10 more sources
Quantum Mechanical/Molecular Mechanical Analysis of the Catalytic Mechanism of Phosphoserine Phosphatase [PDF]
Molecules, 2018 Phosphoserine phosphatase (PSP), a member of the haloacid dehalogenase (HAD) superfamily that comprises the vast majority of phosphotransferases, is likely a steady-state regulator of the level of d-serine in the brain.
Petra Imhof, Jeremy C Smith
exaly +8 more sources
L-serine deficiency: on the properties of the Asn133Ser variant of human phosphoserine phosphatase [PDF]
Scientific ReportsThe non-essential amino acid L-serine is involved in a number of metabolic pathways and in the brain its level is largely due to the biosynthesis from the glycolytic intermediate D-3-phosphoglycerate by the phosphorylated pathway (PP).
Loredano Pollegioni +10 more
doaj +6 more sources
Identification and Repurposing of Trisubstituted Harmine Derivatives as Novel Inhibitors of Mycobacterium tuberculosis Phosphoserine Phosphatase [PDF]
Molecules, 2020 Mycobacterium tuberculosis is still the deadliest bacterial pathogen worldwide and the increasing number of multidrug-resistant tuberculosis cases further complicates this global health issue. M.
Elise Pierson +5 more
doaj +4 more sources
Downregulation of phosphoserine phosphatase potentiates tumor immune environments to enhance immune checkpoint blockade therapy [PDF]
Journal for ImmunoTherapy of Cancer, 2023 Background Effects of immune checkpoint blockade (ICB) treatment in hepatocellular carcinoma (HCC) are limited. The current study explored the possibility of exploiting tumor metabolic switches to enhance HCC sensitivity to immune therapies.Methods ...
Yan Wu +8 more
doaj +3 more sources
Phosphoserine phosphatase B facilitates indole metabolism to indole-3-lactic acid [PDF]
Applied Microbiology and BiotechnologyIntestinal bacteria can convert indole to a range of compounds; however, the precise enzymatic processes facilitating this conversion have not been fully elucidated.
Hiroaki Konishi +5 more
doaj +3 more sources
Phosphoserine phosphatase as a prognostic biomarker in patients with gastric cancer and its potential association with immune cells [PDF]
BMC Gastroenterology, 2022 Background Because of dismal prognosis in gastric cancer, identifying relevant prognostic factors is necessary. Phosphoserine phosphatase (PSPH) exhibits different expression patterns in many cancers and has been reported to affect the prognosis of ...
Ma-Yan Huang +10 more
doaj +3 more sources
Phosphoserine phosphatase as an indicator for survival through potentially influencing the infiltration levels of immune cells in neuroblastoma [PDF]
Frontiers in Cell and Developmental Biology, 2022 Introduction: Metabolic deregulation, a hallmark of cancer, fuels cancer cell growth and metastasis. Phosphoserine phosphatase (PSPH), an enzyme of the serine metabolism pathway, has been shown to affect patients’ prognosis in many cancers but its ...
Liang Zeng +8 more
doaj +3 more sources
Overexpression of the Phosphoserine Phosphatase-Encoding Gene (AtPSP1) Promotes Starch Accumulation in Lemna turionifera 5511 under Sulfur Deficiency [PDF]
Plants, 2023 Duckweeds are well known for their high accumulation of starch under stress conditions, along with inhibited growth. The phosphorylation pathway of serine biosynthesis (PPSB) was reported as playing a vital role in linking the carbon, nitrogen, and ...
Lei Wang +5 more
doaj +3 more sources