Frontiers in Cell and Developmental Biology, 2022 Introduction: Metabolic deregulation, a hallmark of cancer, fuels cancer cell growth and metastasis. Phosphoserine phosphatase (PSPH), an enzyme of the serine metabolism pathway, has been shown to affect patients’ prognosis in many cancers but its ...
Liang Zeng, Liang-Jun Qin, Lei Miao
exaly +3 more sources
Architecture of genome-wide transcriptional regulatory network reveals dynamic functions and evolutionary trajectories in Pseudomonas syringae [PDF]
eLifeThe model Gram-negative plant pathogen Pseudomonas syringae utilises hundreds of transcription factors (TFs) to regulate its functional processes, including virulence and metabolic pathways that control its ability to infect host plants.
Yue Sun +6 more
doaj +2 more sources
Research based on serine metabolism indicates mesenchymal stem cells alleviate psoriasis by regulating the PSPH-PINK1-Parkin-NLRP3 pathway in HaCaT [PDF]
Stem Cell Research & TherapyBackground Psoriasis is a refractory immune-related disease. In recent years, it has been discovered that mesenchymal stem cells (MSCs) can be used as a new therapeutic approach for psoriasis, but their potential therapeutic mechanism remains unclear ...
Qing Lin +5 more
doaj +2 more sources
ΔNp63α drives serine synthesis to promote carboplatin resistance in NSCLC [PDF]
Cell Death and DiseaseSerine metabolism is a critical vulnerability in cancer; however, its role in mediating therapeutic resistance in non-small cell lung cancer (NSCLC) remains incompletely understood.
Liyuan Deng +6 more
doaj +2 more sources
Case report: Upper gastrointestinal bleeding associated with pancreatic segmental portal hypertension: six case reports and literature review [PDF]
Frontiers in MedicineBackgroundPancreatic segmental portal hypertension (PSPH) is a clinical syndrome in which splenic vein hypertension is caused by obstruction, stenosis, or thrombosis of the splenic veins in the primary pancreatic disease.
Qian Miao +5 more
doaj +2 more sources
Protein post-translational modifications in serine synthetic pathway: functions and molecular mechanisms [PDF]
Cell Communication and SignalingSerine is a non-essential amino acid, serving as a precursor for other amino acids, lipids, and nucleotide synthesis. Its supply is ensured by two main mechanisms: exogenous uptake and endogenous synthesis.
Mincong Shu, Yuhan Liu, Jianbin Wang
doaj +2 more sources
Sertraline/chloroquine combination therapy to target hypoxic and immunosuppressive serine/glycine synthesis-dependent glioblastomas [PDF]
OncogenesisThe serine/glycine (ser/gly) synthesis pathway branches from glycolysis and is hyperactivated in approximately 30% of cancers. In ~13% of glioblastoma cases, we observed frequent amplifications and rare mutations in the gene encoding the enzyme PSPH ...
Anaís Sánchez-Castillo +15 more
doaj +2 more sources
A systematic characterization of amino acid metabolism–related genes reveals molecular subtypes and a prognostic signature in bladder cancer [PDF]
Frontiers in OncologyBackgroundAmino acid metabolism is integral to tumor proliferation, redox control, and immune regulation. Yet, studies in bladder cancer have largely centered on single amino acids, leaving the broader metabolic gene network insufficiently characterized ...
Junrui He +13 more
doaj +2 more sources
Transcatheter splenic artery embolization for pancreatic sinistral portal hypertension with gastrointestinal blee-ding: a case report [PDF]
Waike lilun yu shijian, 2022 Pancreatic sinistral portal hypertension (PSPH) is a rare entity resulting from splenic vein obstruction and is characterized by splenomegaly, gastric and/or esophageal varices with normal liver function.
CHEN Xiaojuan, ZHANG Wen, CAI Yu
doaj +1 more source
Journal for ImmunoTherapy of Cancer, 2023 Background Effects of immune checkpoint blockade (ICB) treatment in hepatocellular carcinoma (HCC) are limited. The current study explored the possibility of exploiting tumor metabolic switches to enhance HCC sensitivity to immune therapies.Methods ...
Yan Wu +8 more
doaj +1 more source