Results 21 to 30 of about 2,361 (179)

Serine Ameliorates Cadmium-Induced Testicular Injury by Regulating the PGAM1/PHGDH Signaling Pathway. [PDF]

J Biochem Mol Toxicol
Serine mitigates cadmium‐induced testicular injury in mice by inhibiting the PGAM1/PHGDH pathway, restoring ion homeostasis and glycolysis, and relieving oxidative stress, inflammation, fibrosis, and apoptosis. ABSTRACT Cadmium (Cd) is a widespread environmental contaminant that impairs male reproductive function; however, the metabolic mechanisms ...
Wang X, Luo N, Ma Y, Zou H, Tong X, Zhu J, Song R, Zhao H, Liu Z.   +8 more
europepmc   +2 more sources

Downregulation of phosphoserine phosphatase potentiates tumor immune environments to enhance immune checkpoint blockade therapy

Journal for ImmunoTherapy of Cancer, 2023
Background Effects of immune checkpoint blockade (ICB) treatment in hepatocellular carcinoma (HCC) are limited. The current study explored the possibility of exploiting tumor metabolic switches to enhance HCC sensitivity to immune therapies.Methods ...
Yan Wu, Da Jiang, Zhi-Peng Peng, Xing-Chen Liu, Yong-Hao Ruan, Ai-Qi Huang, Wan-Ru Ning, Ze-Zhou Jiang, Limin Zheng   +8 more
doaj   +1 more source

Hypoxia controls the expression of genes responsible for serine synthesis in U87MG cells on ERN1-dependent manner

Endocrine Regulations, 2023
Objective. Serine synthesis as well as endoplasmic reticulum stress and hypoxia are important factors of malignant tumor growth including glioblastoma.
Sliusar Myroslava Y., Minchenko Dmytro O., Khita Olena O., Tsymbal Dariia O., Viletska Yuliia M., Luzina Olha Y., Danilovskyi Serhij V., Ratushna Oksana O., Minchenko Oleksandr H.   +8 more
doaj   +1 more source

Effect of Enzymatic Hydrolysis on the Zinc Binding Capacity and in vitro Gastrointestinal Stability of Peptides Derived From Pumpkin (Cucurbita pepo L.) Seeds

Frontiers in Nutrition, 2021
Zinc is a crucial micronutrient for maintaining body immune system and metabolism function. However, insufficient intake from diet may lead to zinc deficiency and impair normal body function.
Dan Lu, Mengyao Peng, Min Yu, Bo Jiang, Hong Wu, Jingjing Chen   +5 more
doaj   +1 more source

Expression of Serine Biosynthesis Pathway Genes in Breast Muscles of Iranian Native Turkeys with Divergent Feed Efficiency [PDF]

پژوهشهای علوم دامی ایران, 2022
Introduction: Feed is the main cost part of poultry production. High feed efficiency poultry produce less feed and less excrement per unit weight gain. Therefore, a comprehensive understanding of the biological mechanisms that control feed efficiency is ...
Zahra Pezeshkian, Seyed Ziaeddin Mirhoseini, Shahrokh Ghovvati, Esmaeil Ebrahimie   +3 more
doaj   +1 more source

Rapid review on monkeypox policies among the G20 nations: relevance to policy and practitioner [version 1; peer review: 2 approved]

F1000Research, 2022
Background: Monkeypox has been declared as a Public Health Emergency of International Concern (PHEIC) by the WHO Director General (WHO-DG). Most of the G20 nations have reported Monkeypox outbreak.
Anupama DS, Nachiket Gudi, Sanjay Pattanshetty, Rohit Raj, Viola Savy Dsouza, Helmut Brand   +5 more
doaj   +1 more source

An Assessment of the Economic Feasibility of Selected Surgeries in the Obstetrics and Gynaecology Department under Community-Based Health Insurance (CBHI) in a Tertiary Care Hospital in South India

Global Health, Epidemiology and Genomics, 2021
Community-Based Health Insurance (CBHI) is a form of micro health insurance targeted at low-income groups that permits for grouping of assets to tackle the expenses of future, uncertain, health-related circumstances. According to the International Labour
Jatoveda Haldar, Rajesh Kamath, Kramer Stallone D’lima, Jossil Nazareth   +3 more
doaj   +1 more source

Additional file 1 of p63 orchestrates serine and one carbon metabolism enzymes expression in head and neck cancer

, 2023
Additional file 1: Fig S1. Serine and OCM enzymes are differentially expressed in single-cell RNAseq of HNSCC and leukoplakia samples. (a) Average expression of serine and one carbon metabolism enzymes in single-cell RNA sequencing of normal and HNSCC ...
Xue Yang (17369186), Carlo Ganini (17369183), Francesca Bernassola (17369195), Angela Cappello (17369174), Giulia Tosetti (17369177), Artem Smirnov (17369180), Eleonora Candi (17369198), Yufang Shi (17369189), Ying Wang (17369192), Gerry Melino (12209138)   +9 more
core   +1 more source

Case Report of Dual Variants in <i>SLC1A4</i> and <i>APOE</i>: A Possible Link Between Amino Acid and Lipid Metabolism. [PDF]

Clin Case Rep
ABSTRACT Spastic tetraplegia, thin corpus callosum, and progressive microcephaly (SPATCCM) is a rare autosomal recessive neurodevelopmental disorder linked to biallelic variants in the SLC1A4 gene, which encodes the ASCT1 amino acid transporter critical for neutral amino acid uptake in neurons.
Qaisiya M, Altell K, Alhroub W, Ramlawe M, Battocchio E, Guarnieri F, Altamimi M.   +6 more
europepmc   +2 more sources

ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction

Cell Reports, 2021
Summary: The serine synthesis pathway (SSP) involving metabolic enzymes phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1), and phosphoserine phosphatase (PSPH) drives intracellular serine biosynthesis and is indispensable ...
Xingyao Li, Daniel Gracilla, Lun Cai, Mingyi Zhang, Xiaolin Yu, Xiaoguang Chen, Junran Zhang, Xiaochun Long, Han-Fei Ding, Chunhong Yan   +9 more
doaj   +1 more source