Results 1 to 10 of about 1,554,099 (296)

The phosphorylated pathway of serine biosynthesis affects sperm, embryo, and sporophyte development, and metabolism in Marchantia polymorpha [PDF]

Communications Biology
Serine metabolism is involved in various biological processes. Here we investigate primary functions of the phosphorylated pathway of serine biosynthesis in a non-vascular plant Marchantia polymorpha by analyzing knockout mutants of MpPGDH encoding 3 ...
Mengyao Wang, Hiromitsu Tabeta, Kinuka Ohtaka, Ayuko Kuwahara, Ryuichi Nishihama, Toshiki Ishikawa, Kiminori Toyooka, Mayuko Sato, Mayumi Wakazaki, Hiromichi Akashi, Hiroshi Tsugawa, Tsubasa Shoji, Yozo Okazaki, Keisuke Yoshida, Ryoichi Sato, Ali Ferjani, Takayuki Kohchi, Masami Yokota Hirai   +17 more
doaj   +6 more sources

Correlation between PI3K/PDK1/AKT pathway-related protein levels and sperm motility in Duroc Boars [PDF]

Journal of Animal Science and Technology
Male infertility is an increasing global health concern, with reduced sperm motility being a major contributing factor. Among various molecular mechanisms, the phosphoinositide 3-kinase (PI3K)/phosphoinositide-dependent protein kinase-1 (PDK1)/protein ...
Seung-Ik Jang, Jae-Hwan Jo, Claudine Uwamahoro, Eun-Ju Jung, Woo-Jin Lee, Jeong-Won Bae, Chanwool Park, Junkoo Yi, Daehyun Kim, Joonho Moon, Dong Yep Oh, Jae Jung Ha, Woo-Sung Kwon   +12 more
doaj   +2 more sources

The essential role of the phosphorylated pathway of serine biosynthesis in Arabidopsis. [PDF]

Plant Signal Behav, 2013
Muñoz-Bertomeu J, Anoman A, Flores-Tornero M, Toujani W, Rosa-Téllez S, Fernie AR, Roje S, Segura J, Ros R.   +8 more
europepmc   +2 more sources

The Chinese Herb Codonopsis pilosula Isolate Isorhapontigenin protects against oxidative stress injury by inhibiting the activation of PI3K/Akt signaling pathway [PDF]

Journal of Integrative Neuroscience, 2020
We investigated the effects of the Chinese herb Codonopsis pilosula isolate isorhapontigenin on antioxidant factor and the PI3K/Serine/Akt signaling pathway in Parkinson's disease.
Youquan Gu, Tianhong Wang, Jun Chen, Zhe Zhou, Ying Wang, Jiangjun Chen, Ning Liu, Zhenxiu Jiang
doaj   +1 more source

Phosphoserine Aminotransferase Pathogenetic Variants in Serine Deficiency Disorders: A Functional Characterization

Biomolecules, 2023
In humans, the phosphorylated pathway (PP) converts the glycolytic intermediate D-3-phosphoglycerate (3-PG) into L-serine through the enzymes 3-phosphoglycerate dehydrogenase, phosphoserine aminotransferase (PSAT) and phosphoserine phosphatase.
Francesco Marchesani, Annalisa Michielon, Elisabetta Viale, Annalisa Bianchera, Davide Cavazzini, Loredano Pollegioni, Giulia Murtas, Andrea Mozzarelli, Stefano Bettati, Alessio Peracchi, Barbara Campanini, Stefano Bruno   +11 more
doaj   +1 more source

Differential induction of TLR2/c-Jun and NF-κB signaling pathway in human keratinocytes infected by Trichophyton rubrum and Microsporum gypseum

Pifu-xingbing zhenliaoxue zazhi, 2021
Objective: To explore the activation of TLR2/c-Jun and NF-κB signaling pathway in human keratinocytes infected by different ecological classifications of dermatophytes.
Zhen SU, Weiwei DENG, Shuting ZHAN, Panpan LIANG, Meirong LI, Songchao YIN, Jian CHEN   +6 more
doaj   +1 more source

miRNAs may involve in ventricular septal defect through regulating the MAPK pathway [PDF]

Jichu yixue yu linchuang, 2022
Objective To investigate the role of miRNAs in pathogenesis of ventricular septal defect. Methods The miRNAs differential expression in whole blood samples from ventricular septal defect (VSD) group and normal group was analyzed by miRNAs expression ...
JIANG Hui, ZHANG Lin
doaj   +1 more source

Proteomic and phosphorylated proteomic landscape of injured lung in juvenile septic rats with therapeutic application of umbilical cord mesenchymal stem cells

Frontiers in Immunology, 2022
Acute lung injury (ALI) is the most common complication of sepsis. Intravenous injection of HUMSCs can regulate the level of circulating endothelial cytokines and alleviate lung injury in juvenile septic rats.
Hongwu Wang, Hongwu Wang, Hongwu Wang, Junlin Luo, Aijia Li, Xing Su, Chuiqin Fang, Lichun Xie, Lichun Xie, Lichun Xie, Yi Wu, Feiqiu Wen, Feiqiu Wen, Feiqiu Wen, Yufeng Liu, Tianyou Wang, Yong Zhong, Lian Ma, Lian Ma, Lian Ma, Lian Ma   +20 more
doaj   +1 more source

Identification and Biochemical Characterization of the Serine Biosynthetic Enzyme 3-Phosphoglycerate Dehydrogenase in Marchantia polymorpha

Frontiers in Plant Science, 2018
L-serine is an important molecule in all living organisms, and thus its biosynthesis is considered to be regulated according to demand. 3-Phosphoglycerate dehydrogenase (PGDH), the first committed enzyme of the phosphorylated pathway of L-serine ...
Hiromichi Akashi, Hiromichi Akashi, Eiji Okamura, Ryuichi Nishihama, Takayuki Kohchi, Masami Y. Hirai, Masami Y. Hirai   +6 more
doaj   +1 more source

Phosphorylation of RCC1 on Serine 11 Facilitates G1/S Transition in HPV E7-Expressing Cells

Biomolecules, 2021
Persistent infection of high-risk human papillomavirus (HR-HPV) plays a causal role in cervical cancer. Regulator of chromosome condensation 1 (RCC1) is a critical cell cycle regulator, which undergoes a few post-translational modifications including ...
Xiaoyan Hou, Lijun Qiao, Ruijuan Liu, Xuechao Han, Weifang Zhang   +4 more
doaj   +1 more source