Results 41 to 50 of about 1,554,099 (296)

adaptive capabilities of the pi3k/akt/mtor pathway in acute myeloid leukemia revealed by the use of selective inhibitors [PDF]

, 2013
Because of its aberrant activation, the PI3K/AKT/mTOR signaling pathway represents a pharmacological target in blast cells from patients with acute myelogenous leukemia (AML).
Bertacchini, Jessika <1980>
core   +1 more source

Ortho-Topolin Riboside Induced Differentiation through Inhibition of STAT3 Signaling in Acute Myeloid Leukemia HL-60 Cells

Turkish Journal of Hematology, 2019
Objective: We previously demonstrated that ortho-topolin riboside (oTR) as a naturally occurring cytokinin secreted from Populus × robusta has great potential anticancer effects via the mitochondrial apoptotic pathway and endoplasmic reticulum stress ...
Li Wang, Jiao Cheng, Fanlin Lin, Shengxian Liu, Hui Pan, Mingda Li, Shanshan Li, Na Li, Weiping Li   +8 more
doaj   +1 more source

Increased STAT1 signaling in endocrine-resistant breast cancer [PDF]

, 2014
Funding: China Scholarship Council, University of Edinburgh, Scottish Funding Council and Breakthrough Breast Cancer.Proteomic profiling of the estrogen/tamoxifen-sensitive MCF-7 cell line and its partially sensitive (MCF-7/LCC1) and fully resistant (MCF-
Thomas Jeremy S., Faratian Dana, Huang Rui, Sims Andrew H., Dana Faratian (171110), Simon P. Langdon, Danielle Wilson (550968), David J. Harrison (171106), Jeremy S. Thomas, Dana Faratian, Rui Huang, Wilson Danielle, Harrison David J., David J. Harrison, Danielle Wilson, Simon P Langdon, Thomas, Jeremy S, Sims, Andrew H, Andrew H. Sims (108040), Harrison, David J, Rui Huang (141490), Huang, Rui, Simon P. Langdon (207293), Wilson, Danielle, David J Harrison, Thomas, Jeremy, Langdon Simon P., Faratian, Dana, Andrew H. Sims, Andrew H Sims, Jeremy S Thomas, Jeremy S. Thomas (550969), Langdon, Simon P   +32 more
core   +2 more sources

Modulating the serine metabolism in human differentiated astrocytes: an integrated multi omics approach

Frontiers in Cellular Neuroscience
IntroductionAstrocytes are the major source of L-serine (L-Ser) in the brain: the glycolytic intermediate D-3-phosphoglycerate is converted into L-Ser through the phosphorylated pathway (PP) made up of three enzymes, phosphoglycerate dehydrogenase (PHGDH)
Farida Tripodi, Elisa Maffioli, Silvia Sacchi, Valentina Rabattoni, Zoraide Motta, Claudia Bearzi, Gabriella Tedeschi, Gabriella Tedeschi, Loredano Pollegioni, Paola Coccetti   +9 more
doaj   +1 more source

Endogenous repair by the activation of cell survival signalling cascades during the early stages of rat Parkinsonism. [PDF]

PLoS ONE, 2012
Here we report a previously unknown self repair mechanism during extremely early stages of rat Parkinsonism. Two important cell survival signaling cascades, Phosphatidylinositol-3 kinases (PI3K)/Akt pathway and extracellular signal-regulated kinase ...
Nga-Ping Lui, Liang-Wei Chen, Wing-Ho Yung, Ying-Shing Chan, Ken Kin-Lam Yung   +4 more
doaj   +1 more source

Exploring Thermal Sensitivities and Adaptations of Oxidative Phosphorylation Pathways

Metabolites, 2022
Temperature shifts are a major challenge to animals; they drive adaptations in organisms and species, and affect all physiological functions in ectothermic organisms. Understanding the origin and mechanisms of these adaptations is critical for determining whether ectothermic organisms will be able to survive when faced with global climate change ...
Hélène Lemieux, Pierre U. Blier
openaire   +3 more sources

Phosphorylation of peptides by a kinase domain in cyanobactin pathways

Nature Communications
Phosphorylation is an important protein post-translational modification and a valuable tool in medicinal chemistry for improving the pharmacological properties of small molecules, but rare in natural product biosynthesis. Here we report phosphorylation in cyanobactins, a family of ribosomally synthesized and post-translationally modified peptides.
Raquel Castelo-Branco, Xiaodan Ouyang, João P. A. Reis, Sara Freitas, Diana Sousa, David P. Fewer, Pedro N. Leão   +6 more
openaire   +3 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Apoptosis of colon cancer CT-26 cells induced polysaccharide from Cyclocarya paliurus and its phosphorylated derivative via intrinsic mitochondrial passway

Food Science and Human Wellness, 2023
In this study, the antitumor properties and the possible molecular mechanisms of Cyclocarya paliurus polysaccharide (CP) and its phosphorylated derivative (P-CP) on CT-26 mouse colon carcinoma cells were investigated.
Liuming Xie, Mingyue Shen, Rong Huang, Xuan Liu, Yue Yu, Hanyu Lu, Jianhua Xie   +6 more
doaj   +1 more source

Recent Patents Related to Phosphorylation Signaling Pathway on Cancer

Recent Patents on DNA & Gene Sequences, 2011
Phosphorylation and dephosphorylation play an important role in the regulation of growth factor and cytokine signal transduction to modulate cell proliferation, differentiation, survival, and apoptosis. In some cellular systems, the information suggests that EGFR, somatostatin receptors, SHP-1, Akt and PI3K can regulate carcinogenesis implied process ...
Acosta, Karina Beatriz, Tibolla, María Marianella, Tiscornia, María Mercedes, Lorenzati, María Angélica, Zapata, Pedro Dario   +4 more
openaire   +3 more sources