Results 21 to 30 of about 1,554,099 (296)
PLoS ONE, 2021 Patients with urothelial carcinoma (UC) experience gemcitabine resistance is a critical issue. The role of hedgehog pathway in the problem was explored.
Yu-Hao Chang +3 more
doaj +1 more source
Total and phosphorylated tau proteins: Evaluation as core biomarker candidates in frontotemporal dementia [PDF]
, 2004 An ever increasing number of patients with neurodegenerative disorders calls for the evaluation of potential diagnostic markers that allow an early diagnosis and an early initiation of specific therapy. Clinical diagnosis of Alzheimer's disease (AD), the
Teipel, S. J. +3 more
core +1 more source
Fibroblasts in head neck squamous cell carcinoma associated with perineural invasion have high level nuclear Yes-Associated Protein (YAP) expression [PDF]
, 2015 Paul A. Reynolds, PhD, is supported by the Melville Trust for the Care and cure of Cancer.We retrospectively studied the expression of Yes-associated protein (YAP) using immunohistochemical staining in 10 cases of head and neck squamous cell carcinoma ...
Gersten, Adam +5 more
core +1 more source
Handbook for safe and ethical peer mentoring with women surviving domestic abuse
A handbook and associated policy documents for Pathway Project, Lichfield, Staffordshire. including process, confidentiality statement and processes to be followed when acting as a volunteer peer mentoring with women surviving domestic ...
Pathway Project, Lichfield +1 more
core +4 more sources
Respiratory Research, 2022 Background Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is the main factor that leads to the deterioration of the disease. Currently, the diagnosis of AECOPD mainly relies on clinical manifestations, good predictors or biomarkers ...
Huijie Wang +9 more
doaj +1 more source
Rosamines Targeting the Cancer Oxidative Phosphorylation Pathway
PLoS ONE, 2014 Reprogramming of energy metabolism is pivotal to cancer, so mitochondria are potential targets for anticancer therapy. A prior study has demonstrated the anti-proliferative activity of a new class of mitochondria-targeting rosamines. This present study describes in vitro cytotoxicity of second-generation rosamine analogs, their mode of action, and ...
Siang Hui Lim +5 more
openaire +4 more sources
Isoform-specific roles of the adaptor protein ShcA in cell signaling [PDF]
, 2005 ShcA is a bona fide adaptor protein without any enzymatic activity. Upon activation of receptor tyrosine kinases, ShcA associates with the receptor and becomes tyrosine phosphorylated.
Kleiner, Sandra
core +1 more source
PLoS ONE, 2011 While there exists a wealth of information about genetic influences on gene expression, less is known about how inherited variation influences the expression and post-translational modifications of proteins, especially those involved in intracellular ...
Janna E Hutz +3 more
doaj +1 more source
Fyn tyrosine kinase increases Apolipoprotein E Receptor 2 levels and phosphorylation.
PLoS ONE, 2014 Apolipoprotein E Receptor 2 (ApoER2) and the tyrosine kinase Fyn are both members of the Reelin pathway, a signaling pathway essential for the laminar formation of the cortex during development and proper dendritic spine density and long-term potential ...
Teal C Burrell +3 more
doaj +1 more source
Comparative analysis of quantitative phosphoproteomics between two tilapias (Oreochromis niloticus and Oreochromis aureus) under low-temperature stress [PDF]
PeerJ, 2023 As an important farmed fish, tilapia has poor tolerance to low-temperatures. At the same time, different tilapia strains have apparent differences in low-temperature tolerance.
Changgeng Yang +5 more
doaj +2 more sources