Results 11 to 20 of about 1,554,099 (296)

L-serine synthesis via the phosphorylated pathway in humans. [PDF]

Cell Mol Life Sci, 2020
L-serine is a nonessential amino acid in eukaryotic cells, used for protein synthesis and in producing phosphoglycerides, glycerides, sphingolipids, phosphatidylserine, and methylenetetrahydrofolate. Moreover, L-serine is the precursor of two relevant coagonists of NMDA receptors: glycine (through the enzyme serine hydroxymethyltransferase), which ...
Murtas G, Marcone GL, Sacchi S, Pollegioni L.   +3 more
europepmc   +4 more sources

Extensive phosphorylation of Smoothened in Hedgehog pathway activation [PDF]

Proceedings of the National Academy of Sciences, 2004
The transmembrane protein Smoothened (Smo) is activated in response to the extracellular protein signal, Hedgehog (Hh), and transmits this state of pathway activity into the cell. Previous studies in Drosophila have correlated pathway activation with Smo accumulation and increased ...
Chi, Zhang, Elizabeth H, Williams, Yurong, Guo, Lawrence, Lum, Philip A, Beachy   +4 more
openaire   +2 more sources

Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses. [PDF]

, 1998
Eukaryotic cells respond to DNA damage and S phase replication blocks by arresting cell-cycle progression through the DNA structure checkpoint pathways.
Lindsay, Howard D., Merl F Hoekstra (16067846), Flaggs, Gail, Martinho, Rui G., Bentley, Nicola J., Howard D Lindsay (16062896), Hoekstra, Merl F., Antony M Carr (10744455), Rui G Martinho (16067837), Carr, Antony M., Anthony J DeMaggio (16067843), Nicola J Bentley (16067849), DeMaggio, Anthony J, Gail Flaggs (16067840)   +13 more
core   +4 more sources

Regulation of Phosphorylation Pathways by p21 GTPases [PDF]

European Journal of Biochemistry, 1996
The oncogenic Ras p21 GTPases regulate phosphorylation pathways that underlie a wealth of activities, including growth and differentiation, in organisms ranging from yeast to human. In metazoa, growth factors trigger conversion of Ras from an inactive GDP‐bound form to an active GTP‐bound form. This activation of Ras leads to activation of Raf.
L, Lim, E, Manser, T, Leung, C, Hall
openaire   +3 more sources

Protein Phosphorylation in Cancer: Unraveling the Signaling Pathways

Biomolecules, 2022
The discovery of protein kinase playing key roles in cancer formation and progression has triggered great interest and stimulated intense research on signaling pathways to develop targeted treatments, as well as to identify prognostic and predictive biomarkers [...]
openaire   +4 more sources

The interplay of double phosphorylation and scaffolding in MAPK pathways [PDF]

Journal of Theoretical Biology, 2012
The MAPK cascades are principal kinase transduction pathways in eukaryotic cells. This family includes RAF/ERK, JNK, and p38 pathways. In the MAPK cascade, the signal is transmitted through three layers of sequentially activated kinases, MAP3K, MAP2K, and MAPK. The latter two kinases require dual phosphorylation for activation. The dual phosphorylation
Kocieniewski, PaweŁ, Faeder, James R., Lipniacki, Tomasz   +2 more
openaire   +2 more sources

Phosphorylation-dependent and -independent pathways of platelet aggregation [PDF]

Biochemical Journal, 1989
We have used the non-specific inhibitor of protein kinases, staurosporine, to investigate the role of protein phosphorylation during aggregation, the mobilization of intracellular Ca2+ (Ca2+)i and intracellular pH (pHi) in thrombin-stimulated platelets.
S P, Watson, S, Hambleton
openaire   +2 more sources

Tyrosine Phosphorylation-Mediated Signaling Pathways in Dictyostelium [PDF]

Journal of Signal Transduction, 2011
While studies on metazoan cell proliferation, cell differentiation, and cytokine signaling laid the foundation of the current paradigms of tyrosine kinase signaling, similar studies using lower eukaryotes have provided invaluable insight for the understanding of mammalian pathways, such as Wnt and STAT pathways.
Tong Sun, Leung Kim
openaire   +3 more sources

Knock-Down of the Phosphoserine Phosphatase Gene Effects Rather N- Than S-Metabolism in Arabidopsis thaliana

Frontiers in Plant Science, 2018
The aim of present study was to elucidate the significance of the phosphorylated pathway of Ser production for Cys biosynthesis in leaves at day and night and upon cadmium (Cd) exposure.
Sladjana Samuilov, Nadine Rademacher, Dominik Brilhaus, Samantha Flachbart, Leila Arab, Stanislav Kopriva, Andreas P. M. Weber, Tabea Mettler-Altmann, Heinz Rennenberg, Heinz Rennenberg   +9 more
doaj   +1 more source

The LDL receptor-related protein 1 (LRP1) regulates the PDGF signaling pathway by binding the protein phosphatase SHP-2 and modulating SHP-2- mediated PDGF signaling events. [PDF]

PLoS ONE, 2013
The PDGF signaling pathway plays a major role in several biological systems, including vascular remodeling that occurs following percutaneous transluminal coronary angioplasty. Recent studies have shown that the LDL receptor-related protein 1 (LRP1) is a
Julie Craig, Irina Mikhailenko, Nathaniel Noyes, Mary Migliorini, Dudley K Strickland   +4 more
doaj   +1 more source