Results 31 to 40 of about 1,554,099 (296)
Phospho-Akt expression is high in a subset of triple negative breast cancer patients [PDF]
, 2014 The most commonly used biomarkers to predict the response of breast cancer patients to therapy are oestrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor 2 (HER2).
Baldacchino, Shawn +6 more
core +1 more source
Journal of Translational Medicine, 2017 Background We investigated antitumor activity and underlying mechanisms of DNA topoisomerase I (TopI) inhibitor gimatecan and irinotecan in gastric cancer (GC) in vitro cell lines and in vivo patient-derived xenograft (PDX) models.
Zuhua Chen +12 more
doaj +1 more source
Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras
Cell Reports, 2018 Summary: Growth factor binding to EGFR drives conformational changes that promote homodimerization and transphosphorylation, followed by adaptor recruitment, oligomerization, and signaling through Ras.
Samantha I. Liang +8 more
doaj +1 more source
Cyclin-dependent kinase modulates budding yeast Rad5 stability during cell cycle. [PDF]
PLoS ONE, 2018 The DNA damage tolerance (DDT) pathway facilitates the bypass of the fork-blocking lesions without removing them through either translesion DNA synthesis or error-free damage bypass mechanism.
Masafumi Hayashi +2 more
doaj +1 more source
Acta Neuropathologica Communications, 2022 Tuberous sclerosis complex (TSC) is a neurodevelopmental disorder caused by mutations in the TSC1 and TSC2 genes and autosomal dominantly inherited. These mutations cause hyperactivation of the mammalian Target of Rapamycin (mTOR) pathway, leading to the
Andy J. Liu +5 more
doaj +1 more source
PKD Phosphorylation as Novel Pathway of KV11.1 Regulation [PDF]
Cellular Physiology and Biochemistry, 2018 Background/Aims: The voltage-gated potassium channel KV11.1 has been originally cloned from the brain and is expressed in a variety of tissues. The role of phosphorylation for channel function is a matter of debate. In this study, we aimed to elucidate the extent and role of protein kinase D mediated phosphorylation.
Steffensen, Annette Buur +7 more
openaire +5 more sources
Journal of Lipid Research, 2019 The sympathetic nervous system (SNS) regulates the functions of white adipose tissue (WAT) and brown adipose tissue (BAT) tightly. Carotid baroreceptor stimulation (CBS) efficiently inhibits SNS activation.
Quan Cao +7 more
doaj +1 more source
Immunohistochemical Assessment of Phosphorylated mTORC1-Pathway Proteins in Human Brain Tumors. [PDF]
PLoS ONE, 2015 Current pathological diagnostics include the analysis of (epi-)genetic alterations as well as oncogenic pathways. Deregulated mammalian target of rapamycin complex 1 (mTORC1) signaling has been implicated in a variety of cancers including malignant ...
Patrick N Harter +11 more
doaj +1 more source
Phosphorylation and Signal Transduction Pathways in Translational Control [PDF]
Cold Spring Harbor Perspectives in Biology, 2018 Protein synthesis, including the translation of specific messenger RNAs (mRNAs), is regulated by extracellular stimuli such as hormones and by the levels of certain nutrients within cells. This control involves several well-understood signaling pathways and protein kinases, which regulate the phosphorylation of proteins that control the translational ...
openaire +3 more sources
The relationships among bovine αS-casein phosphorylation isoforms suggest different phosphorylation pathways [PDF]
Journal of Dairy Science, 2016 Casein (CN) phosphorylation is an important posttranslational modification and is one of the key factors responsible for constructing and stabilizing casein micelles. Variation in phosphorylation degree of αS-CN is of great interest because it is suggested to affect milk technological properties.
Fang, Z.H. +5 more
openaire +4 more sources