Results 51 to 60 of about 1,554,099 (296)

Phosphorylation by p38 MAPK as an Alternative Pathway for GSK3β Inactivation [PDF]

Science, 2008
Glycogen synthase kinase 3β (GSK3β) is involved in metabolism, neurodegeneration, and cancer. Inhibition of GSK3β activity is the primary mechanism that regulates this widely expressed active kinase. Although the protein kinase Akt inhibits GSK3β by phosphorylation at the N terminus, preventing Akt-mediated phosphorylation does not affect the cell ...
Thornton, Tina, Pedraza-Alva, Gustavo, Deng, Bin, Wood, C. David, Aronshtam, Alexander, Clements, James L., Sabio, Guadalupe, Davis, Roger J., Matthews, Dwight E., Doble, Bradley, Rincon, Mercedes   +10 more
openaire   +3 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Luteolin inhibits behavioral sensitization by blocking methamphetamine-induced MAPK pathway activation in the caudate putamen in mice. [PDF]

PLoS ONE, 2014
GOAL: To investigate the effect of luteolin on methamphetamine (MA)-induced behavioral sensitization and mitogen-activated protein kinase (MAPK) signal transduction pathway activation in mice.
Tinglin Yan, Lu Li, Baiyu Sun, Fei Liu, Peng Yang, Teng Chen, Tao Li, Xinshe Liu   +7 more
doaj   +1 more source

Protein phosphorylation pathways disruption by pesticides

Advances in Biological Chemistry, 2013
Phosphosites in the human proteome represent an excellent source of potential biomarkers of pesticide toxicity. In fact, experimental animal models as well as in vitro studies have revealed phosphorylation disruption associated to metabolic regulation, hormone signaling, neuronal function and differentiation, cell survival and death.
Gladis Magnarelli, Teresa Fonovich
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Response of tetraploid Citrus wilsonii Tanaka to drought stress by phosphoproteomics analysis

Xibei zhiwu xuebao
[Objective] Using phosphoproteomics, expression patterns of the phosphorylated proteins were analyzed with tetraploid Citrus wilsonii leaves under drought stress, aiming to reveal the mechanism of tetraploid C.
DENG Xixi, REN Kexin, WEI Li'na, WANG Haotian, HU Jia, JIANG Jinglong   +5 more
doaj   +1 more source

Interleukin‐22 Directly Activates Myocardial STAT3 (Signal Transducer and Activator of Transcription‐3) Signaling Pathway and Prevents Myocardial Ischemia Reperfusion Injury

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
BACKGROUND Interleukin (IL)‐22, a member of the IL‐10 cytokine family, is the only known cytokine that is secreted by immune cells but does not target immune cells; it mainly targets epithelial cells.
Jinya Takahashi, Mai Yamamoto, Hideo Yasukawa, Shoichiro Nohara, Takanobu Nagata, Koutatsu Shimozono, Toshiyuki Yanai, Tomoko Sasaki, Kota Okabe, Tatsuhiro Shibata, Kazutoshi Mawatari, Tatsuyuki Kakuma, Hiroki Aoki, Yoshihiro Fukumoto   +13 more
doaj   +1 more source

Multiple pathways control protein kinase C phosphorylation [PDF]

The EMBO Journal, 2000
The protein kinase C (PKC) family of signal transducers are characterized by a dependence upon lipids for activity. Specifically, the classical (cPKCα, β and γ) and novel (nPKCδ, ϵ, η and θ) PKC isotypes display a physiological requirement for diacylglycerol for activity.
Parekh, D B, Ziegler, W, Parker, P J
openaire   +3 more sources

Activation of Akt at T308 and S473 in alcohol, tobacco and HPV-induced HNSCC:is there evidence to support a prognostic or diagnostic role? [PDF]

, 2014
BACKGROUND: Tobacco, alcohol and HPV infection are associated with increased risk of HNSCC. However, little is known about the underlying signaling events influencing risk.
Ellis, Ian R.; id_orcid, Mohammad R Islam, Macluskey, Michaelina; id_orcid, Sarah J Jones, Islam, Mohammad R.; id_orcid, Ian R Ellis, Michaelina Macluskey, Jones, Sarah J.; id_orcid, Lynda Cochrane, Cochrane, Lynda   +9 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source