Results 21 to 30 of about 465,841 (199)

Phosphoserine phosphatase deficiency in a patient with Williams syndrome. [PDF]

Journal of Medical Genetics, 1997
Decreased serine levels were found in plasma and cerebrospinal fluid (CSF) of a boy with pre- and postnatal growth retardation, moderate psychomotor retardation, and facial dysmorphism suggestive of Williams syndrome. Fluorescence in situ hybridisation with an elastin gene probe indicated the presence of a submicroscopic 7q11.23 deletion, confirming ...
J, Jaeken, M, Detheux, J P, Fryns, J F, Collet, P, Alliet, E, Van Schaftingen   +5 more
openaire   +3 more sources

Upregulation of phosphoserine phosphatase contributes to tumor progression and predicts poor prognosis in non-small cell lung cancer patients. [PDF]

Thorac Cancer, 2019
Growing evidence indicates that high phosphoserine phosphatase (PSPH) expression is associated with tumor prognosis in many types of cancers. However, the role of PSPH in non‐small cell lung cancer (NSCLC) is unclear.
Liao L, Yu H, Ge M, Zhan Q, Huang R, Ji X, Liang X, Zhou X.   +7 more
europepmc   +2 more sources

Novel Report of Phosphoserine Phosphatase Deficiency in an Adult with Myeloneuropathy and Limb Contractures. [PDF]

JIMD Rep, 2016
Serine is a nonessential amino acid that plays a vital role in proper development and functioning of the central nervous system (CNS). Serine deficiency leads to microcephaly, intellectual disability, seizures, and psychomotor retardation in children and severe axonal neuropathy in adults.
Byers HM, Bennett RL, Malouf EA, Weiss MD, Feng J, Scott CR, Jayadev S.   +6 more
europepmc   +5 more sources

Phosphoserine Phosphatase Promotes Lung Cancer Progression through the Dephosphorylation of IRS-1 and a Noncanonical L-Serine-Independent Pathway. [PDF]

Mol Cells, 2019
Phosphoserine phosphatase (PSPH) is one of the key enzymes of the L-serine synthesis pathway. PSPH is reported to affect the progression and survival of several cancers in an L-serine synthesis-independent manner, but the mechanism remains elusive.
Park SM, Seo EH, Bae DH, Kim SS, Kim J, Lin W, Kim KH, Park JB, Kim YS, Yin J, Kim SY.   +10 more
europepmc   +2 more sources

3-phosphoserine phosphatase deficiency [PDF]

Definitions, 2020
Ope n Pe e r Re v ie w on Qe ios Ope n Pe e r Re v ie w on Qe ios 3-phosphoserine phosphatase ...
Inserm
semanticscholar   +2 more sources

Mechanistic Studies of Phosphoserine Phosphatase, an Enzyme Related to P-type ATPases [PDF]

Journal of Biological Chemistry, 1999
Phosphoserine phosphatase belongs to a new class of phosphotransferases forming an acylphosphate during catalysis and sharing three motifs with P-type ATPases and haloacid dehalogenases. The phosphorylated residue was identified as the first aspartate in the first motif (DXDXT) by mass spectrometry analysis of peptides derived from the phosphorylated ...
J F, Collet, V, Stroobant, E, Van Schaftingen   +2 more
openaire   +3 more sources

How calcium inhibits the magnesium‐dependent enzyme human phosphoserine phosphatase [PDF]

European Journal of Biochemistry, 2004
The structure of the Mg2+‐dependent enzyme human phosphoserine phosphatase (HPSP) was exploited to examine the structural and functional role of the divalent cation in the active site of phosphatases. Most interesting is the biochemical observation that a Ca2+ ion inhibits the activity of HPSP, even in the presence of added Mg2+.
Yves, Peeraer, Anja, Rabijns, Jean-François, Collet, Emile, Van Schaftingen, Camiel, De Ranter   +4 more
openaire   +3 more sources

High throughput screen identifies small molecule inhibitors specific for Mycobacterium tuberculosis phosphoserine phosphatase. [PDF]

J Biol Chem, 2014
Background: Phosphoserine phosphatase (PSP) is an essential enzyme involved in l-serine biosynthesis. Results: High throughput screen was performed to identify specific PSP inhibitors with activity against intracellular bacteria.
Arora G, Tiwari P, Mandal RS, Gupta A, Sharma D, Saha S, Singh R.   +6 more
europepmc   +2 more sources

Investigation of bound and unbound phosphoserine phosphatase conformations through elastic network models and molecular dynamics simulations [PDF]

Journal of Biomolecular Structure and Dynamics, 2020
The human phosphoserine phosphatase (hPSP) catalyses the last step in the biosynthesis of L-serine. It involves conformational changes of the enzyme lid once the substrate, phosphoserine (PSer), is bound in the active site.
L. Leherte, M. Haufroid, M. Mirgaux, J. Wouters   +3 more
semanticscholar   +2 more sources

In Silico Systems Biology Approach for Prioritization of Candidate Genes Linked to Lipid Metabolism in the Context of Cardiovascular Disease Susceptibility in a Serbian Cohort [PDF]

Current Issues in Molecular Biology
Background: The population of Serbia faces a significant burden from cardiovascular diseases (CVDs). This study aimed to computationally investigate genetic factors that contribute to the prevalence of these diseases by examining the possible involvement
Tamara Drljača, Vladimir Perović, Nevena Veljković, Branislava Gemović   +3 more
doaj   +2 more sources