Results 31 to 40 of about 465,841 (199)

PSPH Promotes Hepatocellular Carcinoma Progression by Upregulating HIF-1α and Is Regulated by LncRNA GSEC/miR-101-3p [PDF]

Current Issues in Molecular Biology
Hepatocellular carcinoma (HCC) lacks effective early diagnostic markers and is heavily driven by angiogenesis and hypoxia. Emerging evidence indicates that metabolic enzymes and noncoding RNAs coordinate these processes.
Yi Yang, Hang Min, Yuanting Huang, Lingjing Tao, Hao Zhou, Wenbo Zhang, Xiaoshuai Ren, Changyun Huang, Yang Deng, Jun Zhou   +9 more
doaj   +2 more sources

Mitochondria-Dependent Metabolic Reprogramming Enhances Myofibroblast Differentiation and Aggravates Bleomycin-Induced Pulmonary Fibrosis [PDF]

Cells
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by irreversible fibrosis. Aberrant cell differentiation plays a crucial role in the development of IPF. Although recent studies have suggested that mitochondrial
Kai Yazaki, Yosuke Matsuno, Yuki Yabuuchi, Sosuke Matsumura, Kenya Kuramoto, Kazufumi Yoshida, Masashi Matsuyama, Takumi Kiwamoto, Yuko Morishima, Yukio Ishii, Kaori Ishikawa, Kazuto Nakada, Nobuyuki Hizawa   +12 more
doaj   +2 more sources

Study of the structure and inhibition of Mycobacterium avium phosphoserine phosphatase [PDF]

, 2018
Tuberculosis remains currently one of the top ten causes of death worldwide. As a matter of fact, Mycobacterium tuberculosis (M.tb), which is the pathogen responsible for this disease, spreads easily and quickly through saliva droplets in air [1]. Moreover, this mycobacterium is becoming more and more multidrug-resistant [2].
Callaerts, Nephtali; id_orcid
core   +4 more sources

Purification, crystallization and preliminary X-ray diffraction analysis of human phosphoserine phosphatase

Acta Crystallographica Section D Biological Crystallography, 2001
Phosphoserine phosphatase (PSP), a human enzyme involved in the L-serine biosynthesis pathway, has been crystallized using the hanging-drop vapour-diffusion method at 277 K. The crystals are orthorhombic, belonging to space group C222(1), with unit-cell parameters a = 49.03 A, b = 130.25 A, c = 157.29 A.
Yves, Peeraer, Anja, Rabijns, Christel, Verboven, Jean François, Collet, Emile, Van Schaftingen, Camiel, De Ranter   +5 more
openaire   +3 more sources

Gene dosage studies regionally assign the phosphoserine phosphatase gene to 7p15.1 or 2.

Annales de genetique, 1988
Gene dosage studies in subjects with imbalances of the short arm of chromosome 7 have suggested the localization of the phosphoserine phosphatase (PSP) structural gene to p22.1----pter or p15----p21.2. We have found normal enzyme activity in the fibroblasts from a patient with dup (7) (p15.3----pter).
Novelli, G, Dallapiccola, B
core   +4 more sources

Evolution-guided yeast complementation reveals functional differences in human PSPH variants. [PDF]

FEBS Open Bio
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Campa-Álvarez M, Ascencio D, Vallebueno-Estrada M, González-Orozco E, Martínez-Guerrero CE, Montiel R, DeLuna A.   +6 more
europepmc   +2 more sources

Structural Units Important for Activity of a Novel-type Phosphoserine Phosphatase from Hydrogenobacter thermophilus TK-6 Revealed by Crystal Structure Analysis* [PDF]

Journal of Biological Chemistry, 2013
Masaru Tanokura, Masaharu Ishii, Yoko Chiba   +2 more
exaly   +2 more sources

Characterization of M. tuberculosis SerB2, an essential HAD-family phosphatase, reveals novel properties. [PDF]

PLoS ONE, 2014
M. tuberculosis harbors an essential phosphoserine phosphatase (MtSerB2, Rv3042c) that contains two small- molecule binding ACT-domains (Pfam 01842) at the N-terminus followed by the phosphoserine phosphatase (PSP) domain. We found that exogenously added
Gaya Prasad Yadav, Sonal Shree, Ruchi Maurya, Niyati Rai, Diwakar Kumar Singh, Kishore Kumar Srivastava, Ravishankar Ramachandran   +6 more
doaj   +1 more source

Phosphoserine-loaded chitosan membranes promote bone regeneration by activating endogenous stem cells

Frontiers in Bioengineering and Biotechnology, 2023
Bone defects that result from trauma, infection, surgery, or congenital malformation can severely affect the quality of life. To address this clinical problem, a phosphoserine-loaded chitosan membrane that consists of chitosan membranes serving as the ...
Yue Ke, Yue Ke, Yu Ye, Yu Ye, Yu Ye, Jintao Wu, Jintao Wu, Jintao Wu, Yanxia Ma, Yanxia Ma, Yuxin Fang, Yuxin Fang, Fei Jiang, Fei Jiang, Fei Jiang, Jinhua Yu, Jinhua Yu, Jinhua Yu   +17 more
doaj   +1 more source

ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction

Cell Reports, 2021
Summary: The serine synthesis pathway (SSP) involving metabolic enzymes phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1), and phosphoserine phosphatase (PSPH) drives intracellular serine biosynthesis and is indispensable ...
Xingyao Li, Daniel Gracilla, Lun Cai, Mingyi Zhang, Xiaolin Yu, Xiaoguang Chen, Junran Zhang, Xiaochun Long, Han-Fei Ding, Chunhong Yan   +9 more
doaj   +1 more source