Crystallization and preliminary X-ray diffraction analysis of a novel type of phosphoserine phosphatase from Hydrogenobacter thermophilus TK-6 [PDF]
Acta Crystallographica Section F: Structural Biology Communications, 2012 Masaru Tanokura +2 more
exaly +2 more sources
Human L-3-phosphoserine phosphatase: sequence, expression and evidence for a phosphoenzyme intermediate [PDF]
, 1997 We report the sequence of the cDNA encoding human L-3-phosphoserine phosphatase. The encoded polypeptide contains 225 residues and shows 30% sequence identity with the Escherichia coli enzyme.
Isabelle Gerin +10 more
core +1 more source
Nature Communications, 2019 The ribosomal protein RPL10 is frequently mutated in T-cell acute lymphoblastic leukemia (T-ALL). Here, the authors show that it promotes proliferation of T-ALL cells by upregulating the serine biosynthesis enzyme phosphoserine phosphatase which in turn ...
Kim R. Kampen +18 more
doaj +1 more source
Aryloxy Triester Phosphoramidates as Phosphoserine Biocleavable Masking Motifs [PDF]
, 2019 Many cellular protein-protein interactions (PPIs) are mediated by phosphoserine. The specific targeting of these PPIs by phosphoserine-containing small molecules has been scarce due to the dephosphorylation of phosphoserine and its charged nature at ...
Olivia A., Lambourne +6 more
core +2 more sources
Investigation of the Structure and Function of Phosphoserine Phosphatases
The FASEB Journal, 2018 With the ever increasing availability of new genome sequences every year, there is a growing need for functional annotation both on a structural and cellular level. In the case of large superfamilies of proteins with a great deal of sequence divergence, assignment of function based on sequence alone remains difficult. For instance,
Merissa C. Brousseau +2 more
openaire +1 more source
Molecular Basis for the Local Conformational Rearrangement of Human Phosphoserine Phosphatase [PDF]
Journal of Biological Chemistry, 2002 Human phosphoserine phosphatase (HPSP) regulates the levels of glycine and d-serine, the putative co-agonists for the glycine site of the NMDA receptor in the brain. Here, we describe the first crystal structures of the HPSP in complexes with the competitive inhibitor 2-amino-3-phosphonopropionic acid (AP3) at 2.5 A, and the phosphate ion (Pi) and the ...
Hye-Yeon, Kim +15 more
openaire +2 more sources
Frontiers in Plant Science, 2020 Glycerol, a compatible solute, has previously been found to act as an osmoprotectant in some marine Chlamydomonas species and several species of Dunaliella from hypersaline ponds.
James A. Raymond +2 more
doaj +1 more source
Neurospora crassa phosphoserine phosphatase : the effect of pH on the hydrolysis of phosphoserine by enzymes present in wild type and ser(JBM-5) extracts and partial purification and characterization of wild type phosphoserine phosphatase [PDF]
, 1981 The effect of pH on the hydrolysis of phosphoserine by enzymes extracted from Neurospora crassa was found to be different for wild type than for the serine requiring mutant ser(JBM-5). The pH profile of activity in ser(JBM-5) extracts lacks a shoulder at
Beck, Frances Wallace Johnston
core +1 more source
Journal of Experimental & Clinical Cancer Research, 2023 Background Cancer cells undergo cellular adaptation through metabolic reprogramming to sustain survival and rapid growth under various stress conditions. However, how brain tumors modulate their metabolic flexibility in the naturally serine/glycine (S/G)-
Hye Jin Yun +14 more
doaj +1 more source
The TriTryp Phosphatome: analysis of the protein phosphatase catalytic domains [PDF]
, 2007 Background The genomes of the three parasitic protozoa Trypanosoma cruzi, Trypanosoma brucei and Leishmania major are the main subject of this study. These parasites are responsible for devastating human diseases known as Chagas disease, African sleeping
Szoor, Balazs; id_orcid +26 more
core +1 more source