Results 61 to 70 of about 465,841 (199)

Effect of l-serine and magnesium ions on the functional properties of human phosphoserine phosphatase and its pathogenetic variants.

open access: yesBiochimica et Biophysica Acta - Molecular Basis of Disease
L-Ser supply in the central nervous system of mammals mostly relies on its endogenous biosynthesis by the phosphorylated pathway (PP). Defects in any of the three enzymes operating in the pathway result in a group of neurometabolic diseases collectively ...
Francesco Marchesani   +8 more
semanticscholar   +1 more source

Structural Analysis of Phosphoserine Aminotransferase (Isoform 1) From Arabidopsis thaliana– the Enzyme Involved in the Phosphorylated Pathway of Serine Biosynthesis

open access: yesFrontiers in Plant Science, 2018
Phosphoserine aminotransferase (PSAT) is a pyridoxal 5′-phosphate (PLP)-dependent enzyme that catalyzes the conversion of 3-phosphohydroxypyruvate (3-PHP) to 3-phosphoserine (PSer) in an L-glutamate (Glu)-linked reversible transamination reaction.
Bartosz Sekula   +2 more
doaj   +1 more source

Phosphorylation-dependent protein interaction with Trypanosoma brucei 14-3-3 proteins that display atypical target recognition. [PDF]

open access: yesPLoS ONE, 2010
BACKGROUND: The 14-3-3 proteins are structurally conserved throughout eukaryotes and participate in protein kinase signaling. All 14-3-3 proteins are known to bind to evolutionally conserved phosphoserine-containing motifs (modes 1 and/or 2) with high ...
Masahiro Inoue   +7 more
doaj   +1 more source

SAV1 in Cooperation With FKBP52 Participates in Implantation

open access: yesAdvanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao   +10 more
wiley   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

open access: yesAdvanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He   +7 more
wiley   +1 more source

The dynamics of alkaline phosphatase activity during operculum regeneration in the polychaete Pomatoceros lamarckii [PDF]

open access: yes, 2014
RS is supported by a Carnegie Scholarship. Date of Acceptance: 20/06/2014Alkaline phosphatase enzymes are found throughout the living world and fulfil a variety of functions.
Ferrier, David Ellard Keith, Szabo, Reka
core   +1 more source

Phosphoregulation of tropomyosin-actin interaction revealed using a genetic code expansion strategy [version 1; peer review: 2 approved]

open access: yesWellcome Open Research, 2020
Tropomyosins are coiled-coil proteins that regulate the stability and / or function of actin cytoskeleton in muscle and non-muscle cells through direct binding of actin filaments.
Saravanan Palani   +2 more
doaj   +1 more source

Action of Purified Milk Phosphatase on Phosphoserine and on Casein

open access: yesJournal of Dairy Science, 1959
Summary The action of a purified alkaline phosphatase from milk on casein and phosphoserine has been studied. The milk phosphatase preparation has no proteolytic action on casein, but it splits inorganic phosphate from both casein and phosphoserine.
C.A. Zittle, Elizabeth W. Bingham
openaire   +1 more source

Low‐Density Lipoprotein Receptor‐Targeted Biomimetic Nanoplatform Suppresses Glioblastoma Stemness and Remodels Antitumor Immunity via Dual Metabolic Disruption

open access: yesAdvanced Science, EarlyView.
A low‐density lipoprotein receptor‐oriented biomimetic nanoplatform couples brain‐tumor delivery with a mechanistically matched regorafenib‐erythrodiol combination. Concurrent disruption of autophagic nutrient salvage and cholesterol homeostasis collapses bioenergetic and signaling support, suppresses glioblastoma stemness, and promotes immunogenic ...
Yining Jiang   +12 more
wiley   +1 more source

The Phosphohistidine Phosphatase SixA Targets a Phosphotransferase System

open access: yesmBio, 2018
SixA, a well-conserved protein found in proteobacteria, actinobacteria, and cyanobacteria, is the only reported example of a bacterial phosphohistidine phosphatase. A single protein target of SixA has been reported to date: the Escherichia coli histidine
Jane E. Schulte, Mark Goulian
doaj   +1 more source

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