Results 81 to 90 of about 465,841 (199)

Quantum-based modeling implies that bidentate Arg89-substrate binding enhances serine/threonine protein phosphatase-2A(PPP2R5D/PPP2R1A/PPP2CA)-mediated dephosphorylation

Frontiers in Cell and Developmental Biology, 2023
PP2A-serine/threonine protein phosphatases function as heterotrimeric holoenzymes, composed of a common scaffold (A-subunit encoded by PPP2R1A/PPP2R1B), a common catalytic (C-subunit encoded by PPP2CA/PPP2CB), and one of many variable regulatory (B ...
E. Alan Salter, Andrzej Wierzbicki, Richard E. Honkanen, Mark R. Swingle   +3 more
doaj   +1 more source

Biomimetic Core–Shell Liposome Nanoparticles Deplete Lipoproteins and Enhance the Purity of Extracellular Vesicles from Human Blood

Advanced Functional Materials, Volume 36, Issue 80, 5 October 2026.
Lipoprotein‐mimicking nanoparticles (SL‐NPs), comprising Fe3O4@SiO2 cores coated with liposomal bilayers, selectively capture lipoproteins through protein corona formation. The resulting SL‐NP‐lipoprotein complexes can be removed by low‐speed centrifugation, thereby enhancing the purity of small extracellular vesicles (sEVs) isolated from human serum ...
Man‐Di Wang, Andrew J. Perciaccante, David Inman, Bong Hwan Sung, Alissa M. Weaver, Suzanne M. Ponik, Ying Ge, Song Jin   +7 more
wiley   +1 more source

Rationalizing the Influence of the Binding Affinity on the Activity of Phosphoserine Phosphatases

Angewandte Chemie
AbstractThe Sabatier principle states that catalytic activity can be maximized when the substrate binding affinity is neither too strong nor too weak. Recent studies have shown that the activity of several hydrolases is maximized at intermediate values of the binding affinity (Michaelis–Menten constant: Km).
Yoko Chiba, Hideshi Ooka, Marie E. Wintzer, Nao Tsunematsu, Toshihiko Nogawa, Takehiro Suzuki, Naoshi Dohmae, Ryuhei Nakamura   +7 more
openaire   +2 more sources

A Phosphorylation‐Induced Micellization Switch in the Low‐Complexity Domain of TDP‐43

Advanced Science, Volume 13, Issue 56, 9 October 2026.
Phosphorylation of TAR DNA‐binding protein's 43 kDa (TDP‐43) low‐complexity domain by casein kinase 1 delta (CK1δ) acts as a molecular switch, redirecting its self‐assembly from macroscopic phase separation toward finite‐sized, spherical block‐copolymer micelles of ∼30 nm.
Rodrigo F. Dillenburg, Anastasia Lopatina, Hao Ruan, Tom Scheidt, Simone Mosna, Emre Pekbilir, Julia Bieber, Frank Schäfer‐Depoix, Katharina Landfester, Carla Schmidt, Martin M. Möckel, Svenja Morsbach, Friederike Schmid, Dorothee Dormann, Lukas Stelzl, Martin Girard, Edward A. Lemke   +16 more
wiley   +1 more source

Protein tyrosine phosphatase TbPTP1:A molecular switch controlling life cycle differentiation in trypanosomes [PDF]

, 2006
Differentiation in African trypanosomes (Trypanosoma brucei) entails passage between a mammalian host, where parasites exist as a proliferative slender form or a G0-arrested stumpy form, and the tsetse fly.
Szoor, Balazs; id_orcid, Matthews, Keith R., Helen McElhinney, Tabernero, Lydia, Wilson, Jude, Szöor, Balázs, Keith R. Matthews, Matthews, Keith R; id_orcid, Lydia Tabernero, Tabernero, Lydia; id_orcid, McElhinney, Helen, Balázs Szöőr, Jude Wilson   +12 more
core   +1 more source

MAP kinase phosphatase-2 plays a critical role in response to infection by Leishmania mexicana [PDF]

, 2010
In this study we generated a novel dual specific phosphatase 4 (DUSP4) deletion mouse using a targeted deletion strategy in order to examine the role of MAP kinase phosphatase-2 (MKP-2) in immune responses.
McGachy, H.A., Bryant, C.E., Cadalbert, L.C., Alexander, James, Schroeder, J., Shweash, M.S., Plevin, R.J., Kurnik, M., Sloss, C.M., Al-Mutairi, M.S.   +9 more
core   +4 more sources

Protein post-translational modifications in serine synthetic pathway: functions and molecular mechanisms

Cell Communication and Signaling
Serine is a non-essential amino acid, serving as a precursor for other amino acids, lipids, and nucleotide synthesis. Its supply is ensured by two main mechanisms: exogenous uptake and endogenous synthesis.
Mincong Shu, Yuhan Liu, Jianbin Wang
doaj   +1 more source

Rethinking the evolution of eukaryotic metabolism: novel cellular partitioning of enzymes in stramenopiles links serine biosynthesis to glycolysis in mitochondria

BMC Evolutionary Biology, 2017
Background An important feature of eukaryotic evolution is metabolic compartmentalization, in which certain pathways are restricted to the cytosol or specific organelles. Glycolysis in eukaryotes is described as a cytosolic process.
Melania Abrahamian, Meenakshi Kagda, Audrey M. V. Ah-Fong, Howard S. Judelson   +3 more
doaj   +1 more source

Dapagliflozin Attenuates NKCC2 Protein Expression and Alleviates Diabetic Kidney Disease in Salt Loaded‐Hypertensive Diabetic Db/Db Mice

FASEB BioAdvances, Volume 8, Issue 10, October 2026.
In salt‐loaded, hypertensive diabetic db/db mice with diabetic kidney disease, dapagliflozin lowered blood pressure and reduced tubular and glomerular injury. Mechanistically, dapagliflozin increased cullin E3 ligase abundance, promoting degradation of NKCC2.
Zenab Shahzad, Niharika Bala, Arooba Illyas, Amir Kazory, Indra Chandrasekar, Abdel A. Alli   +5 more
wiley   +1 more source

Maternal protein restriction programs the ageing kidney: Proteomic signatures of early‐life origin renal and metabolic dysfunction

The Journal of Physiology, Volume 604, Issue 20, Page 8636-8661, 15 October 2026.
Abstract figure legend Maternal protein restriction (MPR) induced persistent renal histopathological alterations accompanied by elevated serum creatinine levels. Nephron‐segment proteomic analysis revealed region‐specific molecular dysregulation affecting Bowman's capsule (PARK7, oxidative stress sensor; MSN, cytoskeletal organization), the proximal ...
Marina Pereira Pires, Matheus Naia Fioretto, Marcel Rodrigues Ferreira, Isabelle Tenori Ribeiro, Luísa Annibal Barata, Flávia Alessandra Maciel, Lucas Sobrinho Lemos, Renato Mattos, Luiz Marcos Frediane Portela, Patrick Vieira de Souza, Luisa Correia Gomes, Gustavo Monezzi Cordeiro, Wellerson Rodrigo Scarano, Patrícia Aline Boer, Jose Antonio Rocha Gontijo, Luis Antonio Justulin   +15 more
wiley   +1 more source