Results 41 to 50 of about 465,841 (199)

Hypoxia controls the expression of genes responsible for serine synthesis in U87MG cells on ERN1-dependent manner

Endocrine Regulations, 2023
Objective. Serine synthesis as well as endoplasmic reticulum stress and hypoxia are important factors of malignant tumor growth including glioblastoma.
Sliusar Myroslava Y., Minchenko Dmytro O., Khita Olena O., Tsymbal Dariia O., Viletska Yuliia M., Luzina Olha Y., Danilovskyi Serhij V., Ratushna Oksana O., Minchenko Oleksandr H.   +8 more
doaj   +1 more source

Erratum to: Novel Report of Phosphoserine Phosphatase Deficiency in an Adult with Myeloneuropathy and Limb Contractures. [PDF]

JIMD Rep, 2016
Byers HM, Bennett RL, Malouf EA, Weiss MD, Feng J, Scott CR, Jayadev S.   +6 more
europepmc   +2 more sources

Expressions and roles of key enzymes in serine synthesis pathway in NaAsO2-treated HaCaT cells

环境与职业医学, 2022
BackgroundThe key enzymes of serine synthesis pathway (SSP) play an important role in tumor growth, proliferation, and invasion, but their roles in arsenic carcinogenesis are unclear.ObjectiveTo observe the effects of NaAsO2 treatment on the expressions ...
Fengmin LI, Jinmei HAN, Hongqian HUANG, Na WANG, Aihua ZHANG, Xue HAN   +5 more
doaj   +1 more source

Targeting the phosphoserine phosphatase MtSerB2 for tuberculosis drug discovery, an hybrid knowledge based /fragment based approach.

European journal of medicinal chemistry, 2022
Tuberculosis is currently still one of the leading causes of death from a treatable pathogen. The proportion of cases of resistance to common antibiotics is frequently increasing and the development of new drugs with new therapeutic targets is becoming ...
M. Haufroid, A. Volkov, J. Wouters
semanticscholar   +1 more source

Cytocompatibility and Bioactive Ion Release Profiles of Phosphoserine Bone Adhesive: Bridge from In Vitro to In Vivo

Biomedicines, 2022
One major challenge when developing new biomaterials is translating in vitro testing to in vivo models. We have recently shown that a single formulation of a bone tissue adhesive, phosphoserine modified cement (PMC), is safe and resorbable in vivo ...
Kateřina Vrchovecká, Monika Pávková-Goldbergová, Håkan Engqvist, Michael Pujari-Palmer   +3 more
doaj   +1 more source

Phosphoserine Aminotransferase Pathogenetic Variants in Serine Deficiency Disorders: A Functional Characterization

Biomolecules, 2023
In humans, the phosphorylated pathway (PP) converts the glycolytic intermediate D-3-phosphoglycerate (3-PG) into L-serine through the enzymes 3-phosphoglycerate dehydrogenase, phosphoserine aminotransferase (PSAT) and phosphoserine phosphatase.
Francesco Marchesani, Annalisa Michielon, Elisabetta Viale, Annalisa Bianchera, Davide Cavazzini, Loredano Pollegioni, Giulia Murtas, Andrea Mozzarelli, Stefano Bettati, Alessio Peracchi, Barbara Campanini, Stefano Bruno   +11 more
doaj   +1 more source

Phosphoserine Phosphatase Is a Novel Prognostic Biomarker on Chromosome 7 in Colorectal Cancer. [PDF]

Anticancer Research, 2017
Amplification of chromosome 7p (Ch.7p) is common in colorectal cancer (CRC). The aim of this study was to identify potential driver genes on Ch.7p that are overexpressed due to DNA copy number amplification and determine their clinical significance in CRC.We identified phosphoserine phosphatase (PSPH) as a potential driver gene using a CRC dataset from
Kuniaki Sato, Takaaki Masuda, Qing-Jiang Hu, T. Tobo, S. Kidogami, Y. Ogawa, T. Saito, S. Nambara, H. Komatsu, H. Hirata, S. Sakimura, R. Uchi, N. Hayashi, T. Iguchi, H. Eguchi, Shuhei Ito, T. Nakagawa, K. Mimori   +17 more
semanticscholar   +3 more sources

Altered expression of genes involved in the serine synthesis pathway (SSP) in patients with acute myeloid leukemia [PDF]

Journal of Kerman University of Medical Sciences
Background: Acute myeloid leukemia (AML) is characterized by the uncontrolled proliferation of malignant cells, which rely on various metabolic pathways to sustain their survival and growth.
Parinaz Khadem, Ali Keshavarz, Mohammad Hossein Mohammadi, Fateme Mezginejad, Mehdi Allahbakhshian Farsani   +4 more
doaj   +1 more source

Phosphoserine Aminotransferase1 Is Part of the Phosphorylated Pathways for Serine Biosynthesis and Essential for Light and Sugar-Dependent Growth Promotion

Frontiers in Plant Science, 2018
The phosphorylated pathway of serine biosynthesis represents an important pathway in plants. The pathway consist of three reactions catalyzed by the phosphoglycerate dehydrogenase, the phosphoserine aminotransferase and the phosphoserine phosphatase, and
Sabine Wulfert, Stephan Krueger
doaj   +1 more source

Targeting the Serine Pathway: A Promising Approach against Tuberculosis?

Pharmaceuticals, 2019
Tuberculosis is still the leading cause of death by a single infectious agent. Effective chemotherapy has been used and improved since the 1950s, but strains resistant to this therapy and most antibacterial drugs on the market are emerging.
Marie Haufroid, Johan Wouters
doaj   +1 more source