MicroRNA-340 Inhibits Esophageal Cancer Cell Growth and Invasion by Targeting Phosphoserine Aminotransferase 1 [PDF]
Cellular Physiology and Biochemistry, 2015 Background/Aims: Emerging evidence indicates that microRNA (miR)-340 is downregulated in various human cancers, suggesting that it acts as a tumor suppressor.
Shuo Yan +9 more
doaj +3 more sources
Protein post-translational modifications in serine synthetic pathway: functions and molecular mechanisms [PDF]
Cell Communication and SignalingSerine is a non-essential amino acid, serving as a precursor for other amino acids, lipids, and nucleotide synthesis. Its supply is ensured by two main mechanisms: exogenous uptake and endogenous synthesis.
Mincong Shu, Yuhan Liu, Jianbin Wang
doaj +2 more sources
Dietary sulfur amino acid restriction improves glucose homeostasis through hepatic de novo serine synthesis [PDF]
Molecular MetabolismDietary sulfur amino acid restriction (SAAR) improves whole-body glucose homeostasis, elevates liver insulin action, and lowers liver triglycerides. These adaptations are associated with an increased expression of hepatic de novo serine synthesis enzymes,
Andres F. Ortega +9 more
doaj +2 more sources
Statement of Retraction: Examination of the effects of microRNA-145-5p and phosphoserine aminotransferase 1 in colon cancer. [PDF]
Bioengineeredeuropepmc +2 more sources
P.067 Phosphoserine aminotransferase (PSAT) deficiency: Imaging findings in a child with congenital microcephaly [PDF]
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2018 Background: Serine deficiency disorders can result from deficiency in one of three enzymes. Deficiency of the second enzyme in the serine biosynthesis pathway, 3-phosphoserine aminotransferase (PSAT), has been reported in two siblings when the eldest was
G. S. Zaltsberg, H. McMillan, E. Miller
semanticscholar +2 more sources
Cancer Research, 2005 Abstract To understand the biological basis of resistance to endocrine therapy is of utmost importance in patients with steroid hormone receptor–positive breast cancer. Not only will this allow us prediction of therapy success, it may also lead to novel therapies for patients resistant to current endocrine therapy.
Martens, John +18 more
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ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction
Cell Reports, 2021 Summary: The serine synthesis pathway (SSP) involving metabolic enzymes phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1), and phosphoserine phosphatase (PSPH) drives intracellular serine biosynthesis and is indispensable ...
Xingyao Li +9 more
doaj +1 more source
Phosphoserine Aminotransferase in Soybean Root Nodules [PDF]
Plant Physiology, 1986 Phosphoserine aminotransferase activity was detected in the plant and bacteroid fractions from soybean (Glycine max) root nodules. Both total and specific activities increased in the plant fraction during nodule development. Serine-pyruvate aminotransferase activity was not detectable in the plant or bacteroid fractions of these nodules.
P H, Reynolds, D G, Blevins
openaire +2 more sources
Expressions and roles of key enzymes in serine synthesis pathway in NaAsO2-treated HaCaT cells
环境与职业医学, 2022 BackgroundThe key enzymes of serine synthesis pathway (SSP) play an important role in tumor growth, proliferation, and invasion, but their roles in arsenic carcinogenesis are unclear.ObjectiveTo observe the effects of NaAsO2 treatment on the expressions ...
Fengmin LI +5 more
doaj +1 more source
Aryloxy Triester Phosphoramidates as Phosphoserine Biocleavable Masking Motifs [PDF]
, 2019 Many cellular protein-protein interactions (PPIs) are mediated by phosphoserine. The specific targeting of these PPIs by phosphoserine-containing small molecules has been scarce due to the dephosphorylation of phosphoserine and its charged nature at ...
Olivia A., Lambourne +6 more
core +3 more sources