Results 31 to 40 of about 3,020 (150)

Targeting the Serine Pathway: A Promising Approach against Tuberculosis?

Pharmaceuticals, 2019
Tuberculosis is still the leading cause of death by a single infectious agent. Effective chemotherapy has been used and improved since the 1950s, but strains resistant to this therapy and most antibacterial drugs on the market are emerging.
Marie Haufroid, Johan Wouters
doaj   +1 more source

Studies on Phosphoserine Aminotransferase of Sheep Brain

Journal of Biological Chemistry, 1967
Abstract Phosphoserine aminotransferase has been purified about 500-fold from sheep brain extracts by ammonium sulfate precipitation and Sephadex and diethylaminoethyl cellulose chromatography. On ultracentrifugation, the enzyme migrated in a single peak with a sedimentation constant of 4.2 S.
H, Hirsch, D M, Greenberg
openaire   +2 more sources

Stabilization of Notch1 and β-catenin in response to ER- breast cancer-specific up-regulation of PSAT1 mediates distant metastasis

Translational Oncology, 2022
Breast cancer has the highest incidence in women worldwide, with a mortality rate second only to lung cancer. Distant metastasis is the major cause of breast cancer-induced death.
Shuxuan Zhu, Xiaoyu Wang, Lei Liu, Guosheng Ren   +3 more
doaj   +1 more source

AMPK-HIF-1α signaling enhances glucose-derived de novo serine biosynthesis to promote glioblastoma growth

Journal of Experimental & Clinical Cancer Research, 2023
Background Cancer cells undergo cellular adaptation through metabolic reprogramming to sustain survival and rapid growth under various stress conditions. However, how brain tumors modulate their metabolic flexibility in the naturally serine/glycine (S/G)-
Hye Jin Yun, Min Li, Dong Guo, So Mi Jeon, Su Hwan Park, Je Sun Lim, Su Bin Lee, Rui Liu, Linyong Du, Seok-Ho Kim, Tae Hwan Shin, Seong-il Eyun, Yun-Yong Park, Zhimin Lu, Jong-Ho Lee   +14 more
doaj   +1 more source

Characterization of human phosphoserine aminotransferase involved in the phosphorylated pathway of l-serine biosynthesis [PDF]

Biochemical Journal, 2003
In the present study, we first report two forms of human phosphoserine aminotransferase (PSAT) cDNA (HsPSATα and HsPSATβ). HsPSATα has a predicted open reading frame comprising 324 amino acids, encoding a 35.2 kDa protein (PSATα), whereas HsPSATβ consists of an open reading frame comprising 370 amino acids that encodes a 40 kDa protein (PSATβ).
Joo Youn, Baek, Do Youn, Jun, Dennis, Taub, Young Ho, Kim   +3 more
openaire   +2 more sources

RNA-Seq of Phenotypically Distinct Eimeria maxima Strains Reveals Coordinated and Contrasting Maturation and Shared Sporogonic Biomarkers with Eimeria acervulina

Pathogens, 2023
Strains of Eimeria maxima, an enteric parasite of poultry, vary in virulence. Here, we performed microscopy and RNA sequencing on oocysts of strains APU-1 (which exhibits more virulence) and APU-2.
Matthew S. Tucker, Celia N. O’Brien, Alexis N. Johnson, Jitender P. Dubey, Benjamin M. Rosenthal, Mark C. Jenkins   +5 more
doaj   +1 more source

Genomic insight and physiological characterization of thermoacidophilic Alicyclobacillus isolated from Yellowstone National Park

Frontiers in Microbiology, 2023
IntroductionAlicyclobacillus has been isolated from extreme environments such as hot springs, volcanoes, as well as pasteurized acidic beverages, because it can tolerate extreme temperatures and acidity.
Hye Won Kim, Hye Won Kim, Na Kyung Kim, Na Kyung Kim, Alex P. R. Phillips, David A. Parker, David A. Parker, Ping Liu, Ping Liu, Rachel J. Whitaker, Rachel J. Whitaker, Christopher V. Rao, Christopher V. Rao, Christopher V. Rao, Roderick I. Mackie, Roderick I. Mackie, Roderick I. Mackie   +16 more
doaj   +1 more source

From biology to biotechnology: Host‐regulation factors from parasitoid wasps are a source of bioactive molecules with translational potential

Insect Molecular Biology, EarlyView.
Parasitoid wasps deploy maternal and embryonic factors to reprogramme host physiology. Venom, calyx fluid, polydnaviruses, teratocytes and larval secretions act in a coordinated, compartmentalised manner. Host‐regulation factors are promising sources of insecticidal, antimicrobial and bioinspired translational molecules.
Ciro Pedro G. Pinto, Andrew A. Walker, Glenn F. King   +2 more
wiley   +1 more source

Relationship Between Central Sensitization and Genetic Polymorphisms—A Case–Control Study in Fibromyalgia

European Journal of Pain, Volume 30, Issue 6, July 2026.
ABSTRACT Background Fibromyalgia is a syndrome characterised by widespread chronic pain, which is believed to be mediated by a state of central sensitisation (CS). Based on the hypothesis that CS itself could have genetic determinants, our aim was to further explore this pathway.
Nicolas Macian, Christian Dualé, Marine Delay, Vincent Leray, Bruno Pereira, Yoan Renaud, Yvonne Gloor, Jules Desmeules, Gisèle Pickering   +8 more
wiley   +1 more source

Targeting PSAT1 to mitigate metastasis in tumors with p53-72Pro variant

Signal Transduction and Targeted Therapy, 2023
The single-nucleotide polymorphism (SNP) of p53, in particular the codon 72 variants, has recently been implicated as a critical regulator in tumor progression. However, the underlying mechanism remains elusive.
Jingwen Jiang, Hai-Ning Chen, Ping Jin, Li Zhou, Liyuan Peng, Zhao Huang, Siyuan Qin, Bowen Li, Hui Ming, Maochao Luo, Na Xie, Wei Gao, Edouard C. Nice, Qiang Yu, Canhua Huang   +14 more
doaj   +1 more source