Results 11 to 20 of about 3,020 (150)

Overexpression of Phosphoserine Aminotransferase (PSAT)-Enhanced Cadmium Resistance and Accumulation in Duckweed (Lemna turionifera 5511) [PDF]

Plants
Cadmium (Cd) hampers plant growth and harms photosynthesis. Glutamate (Glu) responds to Cd stress and activates the Ca2+ signaling pathway in duckweed, emphasizing Glu’s significant role in Cd stress.
Xu Ma, Yumeng Jiang, Ziyang Qu, Yunwen Yang, Wenqiao Wang, Yuman He, Yiqi Yu, Ximeng Luo, Yuanyuan Liu, Wenqian Han, Qiqi Di, Lin Yang, Yong Wang   +12 more
doaj   +2 more sources

Structural Analysis of Phosphoserine Aminotransferase (Isoform 1) From Arabidopsis thaliana– the Enzyme Involved in the Phosphorylated Pathway of Serine Biosynthesis [PDF]

Frontiers in Plant Science, 2018
Phosphoserine aminotransferase (PSAT) is a pyridoxal 5′-phosphate (PLP)-dependent enzyme that catalyzes the conversion of 3-phosphohydroxypyruvate (3-PHP) to 3-phosphoserine (PSer) in an L-glutamate (Glu)-linked reversible transamination reaction.
Bartosz Sekula, Milosz Ruszkowski, Zbigniew Dauter   +2 more
doaj   +2 more sources

The protective effects of phosphoserine aminotransferase 1 (PSAT1) against hepatic ischemia-reperfusion injury. [PDF]

J Cell Commun Signal, 2023
Hepatic ischemia-reperfusion (I/R) injury is a severe clinical syndrome, causing a profound medical and socioeconomic burden worldwide. This study aimed to explore underlying biomarkers and treatment targets in the progression of hepatic I/R injury. We screened gene expression profiles of the hepatic I/R injury from the Gene Expression Omnibus (GEO ...
Deng Y, Luo H.
europepmc   +3 more sources

Phosphoserine aminotransferase deficiency: a novel disorder of the serine biosynthesis pathway. [PDF]

Am J Hum Genet, 2007
We present the first two identified cases of phosphoserine aminotransferase deficiency. This disorder of serine biosynthesis has been identified in two siblings who showed low concentrations of serine and glycine in plasma and cerebrospinal fluid. Clinically, the index patient presented with intractable seizures, acquired microcephaly, hypertonia, and ...
Hart CE, Race V, Achouri Y, Wiame E, Sharrard M, Olpin SE, Watkinson J, Bonham JR, Jaeken J, Matthijs G, Van Schaftingen E.   +10 more
europepmc   +5 more sources

Phosphoserine Aminotransferase, the Second Step‐Catalyzing Enzyme for Serine Biosynthesis [PDF]

IUBMB Life, 1999
AbstractAs a step toward analyzing the serine biosynthetic pathway in mammals, we have studied the properties of phosphoserine aminotransferase, the second step‐catalyzing enzyme. The Km values for 3‐phosphohydroxypyruvate and L‐phosphoserine are 5 and 35 mu M, respectively, and those for glutamate and alpha‐ketoglutarate are 1.2 and 0.8 mM ...
M J, Basurko, M, Marche, M, Darriet, A, Cassaigne   +3 more
exaly   +3 more sources

MicroRNA-365 suppresses cell growth and invasion in esophageal squamous cell carcinoma by modulating phosphoserine aminotransferase 1 [PDF]

Cancer Management and Research, 2018
Changjiang Sun,1 Xizhi Zhang,1 Yong Chen,1 Qingqing Jia,1 Jianqi Yang,1 Yusheng Shu2 1Department of Oncology, Subei People’s Hospital of Jiangsu Province, Yangzhou, Jiangsu, China; 2Department of Thoracic and Cardiovascular Surgery, Subei People ...
Sun C, Zhang X, Chen Y, Jia Q, Yang J, Shu Y   +5 more
doaj   +2 more sources

Phosphoserine aminotransferase deficiency diagnosed by whole‐exome sequencing and LC–MS/MS reanalysis: A case report and review of literature [PDF]

Molecular Genetics & Genomic Medicine
Background Phosphoserine aminotransferase deficiency (PSATD) is an autosomal recessive disorder associated with hypertonia, psychomotor retardation, and acquired microcephaly.
Jiaci Li, Xinping Wei, Yuchen Sun, Xiaofang Chen, Ying Zhang, Xiaoyu Cui, Jianbo Shu, Dong Li, Chunquan Cai   +8 more
doaj   +2 more sources

MicroRNA-340 Inhibits Esophageal Cancer Cell Growth and Invasion by Targeting Phosphoserine Aminotransferase 1 [PDF]

Cellular Physiology and Biochemistry, 2015
Background/Aims: Emerging evidence indicates that microRNA (miR)-340 is downregulated in various human cancers, suggesting that it acts as a tumor suppressor.
Shuo Yan, Haosheng Jiang, Shiming Fang, Fang Yin, Zhenlei Wang, Yiping Jia, Xianjun Sun, Shaoqiu Wu, Tinghui Jiang, Aiwu Mao   +9 more
doaj   +3 more sources

Comparison of kinetic and enzymatic properties of intracellular phosphoserine aminotransferases from alkaliphilic and neutralophilic bacteria [PDF]

Open Chemistry, 2020
Intracellular pyridoxal 5´-phosphate (PLP) -dependent recombinant phosphoserine aminotransferases (PSATs; EC 2.6.1.52) from two alkaliphilic Bacillus strains were overproduced in Escherichia coli, purified to homogeneity and their enzymological ...
Koivulehto Marianne, Battchikova Natalia, Korpela Saara, Khalikova Elvira, Zavialov Anton, Korpela Timo   +5 more
doaj   +2 more sources

Phosphoserine aminotransferase 1 promotes serine synthesis pathway and cardiac repair after myocardial infarction. [PDF]

Theranostics
Background and Purpose: The permanent loss of cardiomyocytes (CMs) following myocardial infarction (MI), coupled with the heart's limited regenerative capacity, often leads to heart failure. Phosphoserine aminotransferase 1 (PSAT1) is a protein highly expressed in the embryonic mouse heart but markedly downregulated after birth. Despite its presence in
Magadum A, Mallaredy V, Roy R, Joladarashi D, Thej C, Cheng Z, Cimini M, Truongcao M, Chatoff A, Crispim CV, Rigaud VOC, Gonzalez C, Benedict C, Santos CXC, Snyder NW, Khan M, Shah AM, Koch WJ, Kishore R.   +18 more
europepmc   +3 more sources