Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E [PDF]
Journal of Experimental & Clinical Cancer Research, 2019 Background Pancreatic cancer is one of the most malignant cancers. The overall 5-year survival rate of its patients is 8%, the lowest among major cancer types.
Xuhui Ma +4 more
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Phosphoglycerate dehydrogenase stabilizes protein kinase C delta type mRNA to promote hepatocellular carcinoma progression [PDF]
Signal Transduction and Targeted TherapyMetabolic reprogramming not only reshapes cellular bioenergetics but also profoundly influences RNA metabolism through metabolite signaling and the RNA-binding activities of metabolic enzymes.
Bin Cheng +9 more
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Reduction of stratum corneum ceramides in Neu-Laxova syndrome caused by phosphoglycerate dehydrogenase deficiency [PDF]
Journal of Lipid Research, 2018 Neu-Laxova syndrome (NLS) is a very rare autosomal recessive congenital disorder characterized by disturbed development of the central nervous system and the skin and caused by mutations in any of the three genes involved in de novo l-serine biosynthesis:
Takuya Takeichi +14 more
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Phosphoglycerate Dehydrogenase Overexpression Inhibits Ferroptosis to Repress Calcification of Human Coronary Artery Vascular Smooth Muscle Cells via the P53/SLC7A11 Pathway [PDF]
International Journal of General MedicineYuhai Zou,1,* Dongdong Li,1,* Ge Guan,1 Wenting Liu2 1Department of Cardiology, General Hospital of Southern Theatre Command of PLA, Guangzhou, 510010, People’s Republic of China; 2Department of Otorhinolaryngology, Guangzhou First People’s ...
Zou Y, Li D, Guan G, Liu W
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Novel regulatory mechanism of serine biosynthesis associated with 3-phosphoglycerate dehydrogenase in Arabidopsis thaliana [PDF]
Scientific Reports, 2017 The proteinogenic amino acid l-serine is a precursor for various essential biomolecules in all organisms. 3-Phosphoglycerate dehydrogenase (PGDH) is the first committed enzyme of the phosphorylated pathway of l-serine biosynthesis, and is regulated by ...
Eiji Okamura, Masami Yokota Hirai
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3-Phosphoglycerate dehydrogenase: a potential target for cancer treatment. [PDF]
Cell Oncol (Dordr), 2021 Metabolic changes have been recognized as an important hallmark of cancer cells. Cancer cells can promote their own growth and proliferation through metabolic reprogramming. Particularly, serine metabolism has frequently been reported to be dysregulated in tumor cells.
Li M +7 more
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Prognostic value of serum phosphoglycerate dehydrogenase and glycine levels in breast cancer [PDF]
Menopause ReviewHussam Abd Jassem, Anwar Jasib Thaaban
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High Phosphoglycerate Dehydrogenase Expression Induces Stemness and Aggressiveness in Thyroid Cancer [PDF]
Thyroid, 2020 Min Ji Jeon, Mi-Hyeon You, Ji Min Han
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The Role of D-3-Phosphoglycerate Dehydrogenase in Cancer. [PDF]
Int J Biol Sci, 2020 Serine, a non-essential amino acid, can be imported from the extracellular environment by transporters and de novo synthesized from glycolytic 3-phosphoglycerate (3-PG) in the serine biosynthetic pathway (SSP). It has been reported that active serine synthesis might be needed for the synthesis of proteins, lipids, and nucleotides and the balance of ...
Zhao X, Fu J, Du J, Xu W.
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Correction: Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E [PDF]
Journal of Experimental & Clinical Cancer ResearchXuhui Ma +4 more
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