Results 11 to 20 of about 170,695 (197)

Phosphoglycerate dehydrogenase and Alzheimer’s disease [PDF]

EXCLI Journal : Experimental and Clinical Sciences
EXCLI Journal; 24:Doc401; ISSN 1611 ...
Quan-Ying Liu, Shuang-Qing Zhang
doaj   +4 more sources

Biochemical and Biophysical Characterization of Recombinant Human 3-Phosphoglycerate Dehydrogenase. [PDF]

Int J Mol Sci, 2021
The human enzyme D-3-phosphoglycerate dehydrogenase (hPHGDH) catalyzes the reversible dehydrogenation of 3-phosphoglycerate (3PG) into 3-phosphohydroxypyruvate (PHP) using the NAD+/NADH redox cofactor, the first step in the phosphorylated pathway producing L-serine.
Murtas G, Marcone GL, Peracchi A, Zangelmi E, Pollegioni L.   +4 more
europepmc   +8 more sources

3‐phosphoglycerate dehydrogenase deficiency in a patient with West syndrome [PDF]

Developmental Medicine & Child Neurology, 2000
3‐phosphoglycerate dehydrogenase deficiency is a severe but treatable disorder of serine synthesis, first described in 1996 (Jaeken et al. 1996a). The patient presented with West syndrome, severe psychomotor delay, failure to thrive, microcephaly, atypical ocular movements, and pyramidal signs.
Pineda, M, Vilaseca, MA, Artuch, R, Santos, S, Gonzalez, MMG, Sau, I, Aracil, A, Van Schaftingen, E, Jaeken, J   +8 more
openaire   +4 more sources

Moonlighting functions of phosphoglycerate dehydrogenase in cancer

Cell Reports
Summary: Phosphoglycerate dehydrogenase (PHGDH) is traditionally known for catalyzing the conversion of 3-phosphoglycerate (3-PG) to 3-phosphonooxypyruvate (3-PHP), a key step in the de novo synthesis of serine.
Chuanlong Wang, Sanqi An, Lingyang Zhao, Shuo Li, Jia Huang, Wenkai Ren   +5 more
doaj   +3 more sources

A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase [PDF]

Molecular and Cellular Oncology, 2016
Serine metabolism is likely to play a critical role in cancer cell growth. A recent study reports the identification of a novel small-molecule inhibitor of serine synthesis that targets 3-phosphoglycerate dehydrogenase (PHGDH), the first enzyme of the serine synthesis pathway, and selectively abrogates the proliferation of PHGDH overexpressing breast ...
Luke Lairson, Costas Lyssiotis, Lewis Cantley   +2 more
exaly   +7 more sources

Expanding the clinical spectrum of 3‐phosphoglycerate dehydrogenase deficiency [PDF]

Journal of Inherited Metabolic Disease, 2010
Abstract3‐Phosphoglycerate dehydrogenase (3‐PGDH) deficiency is considered to be a rare cause of congenital microcephaly, infantile onset of intractable seizures and severe psychomotor retardation. Here, we report for the first time a very mild form of genetically confirmed 3‐PGDH deficiency in two siblings with juvenile onset of absence seizures and ...
Tabatabaie, L., Klomp, L. W. J., Rubio-Gozalbo, M. E., Spaapen, L. J. M., Haagen, A. A. M., Dorland, L., de Koning, T.J.   +6 more
openaire   +6 more sources

Reduction of stratum corneum ceramides in Neu-Laxova syndrome caused by phosphoglycerate dehydrogenase deficiency [PDF]

Journal of Lipid Research, 2018
Neu-Laxova syndrome (NLS) is a very rare autosomal recessive congenital disorder characterized by disturbed development of the central nervous system and the skin and caused by mutations in any of the three genes involved in de novo l-serine biosynthesis:
Takuya Takeichi, Yusuke Okuno, Akane Kawamoto, Takeshi Inoue, Eiko Nagamoto, Chiaki Murase, Eri Shimizu, Kenichi Tanaka, Yuichi Kageshita, Satoshi Fukushima, Michihiro Kono, Junko Ishikawa, Hironobu Ihn, Yoshiyuki Takahashi, Masashi Akiyama   +14 more
doaj   +2 more sources

Phosphoglycerate Dehydrogenase Overexpression Inhibits Ferroptosis to Repress Calcification of Human Coronary Artery Vascular Smooth Muscle Cells via the P53/SLC7A11 Pathway [PDF]

International Journal of General Medicine
Yuhai Zou,1,* Dongdong Li,1,* Ge Guan,1 Wenting Liu2 1Department of Cardiology, General Hospital of Southern Theatre Command of PLA, Guangzhou, 510010, People’s Republic of China; 2Department of Otorhinolaryngology, Guangzhou First People’s ...
Zou Y, Li D, Guan G, Liu W
doaj   +2 more sources

Ser3p (Yer081wp) and Ser33p (Yil074cp) Are Phosphoglycerate Dehydrogenases in Saccharomyces cerevisiae [PDF]

Journal of Biological Chemistry, 2003
Two genes YER081W and YIL074C, renamed SER3 and SER33, respectively, which encode phosphoglycerate dehydrogenases in Saccharomyces cerevisiae were identified. These dehydrogenases catalyze the first reaction of serine and glycine biosynthesis from the glycolytic metabolite 3-phosphoglycerate. Unlike either single mutant, the ser3Delta ser33Delta double
Albers, E., Laizé, Vincent, Blomberg, A., Hohmann, S., Gustafsson, L.   +4 more
openaire   +4 more sources

Novel regulatory mechanism of serine biosynthesis associated with 3-phosphoglycerate dehydrogenase in Arabidopsis thaliana [PDF]

Scientific Reports, 2017
The proteinogenic amino acid l-serine is a precursor for various essential biomolecules in all organisms. 3-Phosphoglycerate dehydrogenase (PGDH) is the first committed enzyme of the phosphorylated pathway of l-serine biosynthesis, and is regulated by ...
Eiji Okamura, Masami Yokota Hirai
doaj   +2 more sources