Results 41 to 50 of about 170,695 (197)

Trypanosoma evansi is alike to Trypanosoma brucei brucei in the subcellular localisation of glycolytic enzymes

Memorias do Instituto Oswaldo Cruz, 2015
Trypanosoma evansi, which causes surra, is descended from Trypanosoma brucei brucei, which causes nagana. Although both parasites are presumed to be metabolically similar, insufficient knowledge of T. evansi precludes a full comparison.
S Andrea Moreno, Mayerly Nava
doaj   +1 more source

Dynamic modelling under uncertainty: the case of Trypanosoma brucei energy metabolism [PDF]

, 2012
Kinetic models of metabolism require detailed knowledge of kinetic parameters. However, due to measurement errors or lack of data this knowledge is often uncertain.
Achcar, Fiona,, Kerkhoven Eduard J., Barrett, M.P., Breitling, Rainer, Breitling, R., Fiona Achcar, Breitling, Rainer,, Bakker, Barbara M.; id_orcid, Achcar, Fiona, Achcar, F., Eduard J. Kerkhoven (187101), Fiona Achcar (187100), Breitling Rainer, Bakker Barbara M., SilicoTryp Consortium, Barrett, Michael P., Rainer Breitling (4371), Michael P Barrett, Bakker, B.M., Barbara M. Bakker (102159), Barrett, Michael P.,, Bakker, Barbara M., Barbara M Bakker, Kerkhoven, Eduard J, Matthews, Keith; id_orcid, Kerkhoven, Eduard J.,, Bakker, Barbara M, Rainer Breitling, Barrett, Michael P, Kerkhoven, E.J., ?, ?, Eduard J Kerkhoven, Achcar Fiona, Barrett Michael P., Bakker, Barbara M.,, Kerkhoven, Eduard J., Michael P. Barrett (167748)   +36 more
core   +6 more sources

Neurotransmitters in 3-phosphoglycerate dehydrogenase deficiency

European Journal of Pediatrics, 2000
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Koning, T.J., Duran, M., Dorland, L., Jakobs, C., Wevers, R.A., Berger, R.A., Poll-The, B.T.   +6 more
openaire   +5 more sources

High expression of phosphoglycerate dehydrogenase predicts poor outcome in patients with high-grade serous ovarian cancer. [PDF]

Oncologist
INTRODUCTION: High-grade serous ovarian cancer (HGSOC) is characterized by high mortality and prevalent recurrences. This study investigates the prognostic value of phosphoglycerate dehydrogenase (PHGDH) in HGSOC which has been linked to metabolic ...
van Wagensveld L, Van Nyen T, Annibali D, Sonke GS, Kruitwagen RFPM, Amant F, Horlings HM.   +6 more
europepmc   +2 more sources

Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor BI-4924 Disrupts Serine Biosynthesis

, 2019
Phosphoglycerate dehydrogenase (PHGDH) is known to be the rate-limiting enzyme in the serine synthesis pathway in humans. It converts glycolysis-derived 3-phosphoglycerate to 3-phosphopyruvate in a co-factor-dependent oxidation reaction.
Peter Ettmayer (3013665), Stephan K. Zahn (3030174), Michelle Burkard (7245791), Harald Weinstabl (2078782), Biljana Peric-Simov (2444032), Jens Quant (7245815), Moriz Mayer (1947241), Géraldine Garavel (7245773), Heribert Arnhof (1947235), Jens Bruchhaus (7245788), Xuechun Zhang (7245809), Fabio Savarese (70678), Darryl B. McConnell (2685361), Karin S. Hofbauer (7245770), Mark Pearson (278362), Andreas Schrenk (6388715), Christoph Harrer (7245803), Dirk Kessler (2556022), Daniela Haering (7245806), Joerg Rinnenthal (6388709), Klaus Rumpel (2436175), Nikolai Mischerikow (2339824), Andreas Zoephel (2556019), Georg Dahmann (2046736), Sophie Mitzner (7245779), Xiaobing Lv (4810647), Yvonne Scherbantin (7245776), Dongyang Li (2203135), Yali Li (198373), Thomas N. Fett (7245782), Gerd Bader (2556040), Tuncay Ciftci (7245797), Matthias Treu (7245767), Alicia Du (7245812), Renate Schnitzer (3346640), Guido Scholz (7245785), Paola Martinelli (122001), Bernhard Wolkerstorfer (4481332), Wolfgang Sommergruber (30929), Thomas Gerstberger (2556016), Roland Kousek (7245794), Bernadette Sharps (7245800)   +41 more
core   +3 more sources

Transient Glycolytic Complexation of Arsenate Enhances Resistance in the Enteropathogen Vibrio cholerae

mBio, 2022
The ubiquitous presence of toxic arsenate (AsV) in the environment has raised mechanisms of resistance in all living organisms. Generally, bacterial detoxification of AsV relies on its reduction to arsenite (AsIII) by ArsC, followed by the export of ...
Emilio Bueno, Víctor Pinedo, Dhananjay D. Shinde, André Mateus, Athanasios Typas, Mikhail M. Savitski, Vinai C. Thomas, Felipe Cava   +7 more
doaj   +1 more source

3-PGDH Deficiency, Seizures, and Microcephaly

Pediatric Neurology Briefs, 1998
The beneficial effects of oral L-serine (up to 500 mg/kg/day) and glycine (200 mg/kg/day) in 2 siblings, aged 7 and 5 years, with 3-phosphoglycerate dehydrogenase (3-PGDH) deficiency are reported from University Children’s Hospital, Utrecht, The ...
J Gordon Millichap
doaj   +1 more source

The activation of 3‐phosphoglycerate dehydrogenase by L‐methionine [PDF]

FEBS Letters, 1970
Feedback inhibition within the metabolic pathways leading to amino acid biosynthesis is well known in a variety of organisms including higher plants [ 1,2] . Most of the information refers to the effects of amino acids on their own biosynthesis but Jensen [3] has recently pointed out that a regulatory superstructure connecting various metabolic ...
openaire   +2 more sources

Expressions and roles of key enzymes in serine synthesis pathway in NaAsO2-treated HaCaT cells

环境与职业医学, 2022
BackgroundThe key enzymes of serine synthesis pathway (SSP) play an important role in tumor growth, proliferation, and invasion, but their roles in arsenic carcinogenesis are unclear.ObjectiveTo observe the effects of NaAsO2 treatment on the expressions ...
Fengmin LI, Jinmei HAN, Hongqian HUANG, Na WANG, Aihua ZHANG, Xue HAN   +5 more
doaj   +1 more source

Phosphoglycerate Dehydrogenase: Potential Therapeutic Target and Putative Metabolic Oncogene [PDF]

, 2015
Exemplified by cancer cells' preference for glycolysis, for example, the Warburg effect, altered metabolism in tumorigenesis has emerged as an important aspect of cancer in the past 10–20 years.
Zogg, Cheryl K.
core   +1 more source