Results 41 to 50 of about 375,644 (216)
Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate. [PDF]
ACS Chem Biol, 2015 Human d-3-phosphoglycerate dehydrogenase (PHGDH), the first enzyme in the serine biosynthetic pathway, is genomically amplified in tumors including breast cancer and melanoma. In PHGDH-amplified cancer cells, knockdown of PHGDH is not fully rescued by exogenous serine, suggesting possible additional growth-promoting roles for the enzyme.
Fan J +7 more
europepmc +5 more sources
Phosphoglycerate dehydrogenase: potential therapeutic target and putative metabolic oncogene. [PDF]
J Oncol, 2014 Exemplified by cancer cells’ preference for glycolysis, for example, the Warburg effect, altered metabolism in tumorigenesis has emerged as an important aspect of cancer in the past 10–20 years. Whether due to changes in regulatory tumor suppressors/oncogenes or by acting as metabolic oncogenes themselves, enzymes involved in the complex network of ...
Zogg CK.
europepmc +4 more sources
Prognostic value of serum phosphoglycerate dehydrogenase and glycine levels in breast cancer [PDF]
Menopause ReviewHussam Abd Jassem, Anwar Jasib Thaaban
doaj +2 more sources
Correction: Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E [PDF]
Journal of Experimental & Clinical Cancer ResearchXuhui Ma +4 more
doaj +2 more sources
The Global mRNA Expression Profiles of Inhibiting PHGDH Induced Cisplatin Resistance in Gastric Cancer [PDF]
Cell Journal, 2022 Objective: Drug resistance is the main hindrance to improve the prognosis of patients with gastric cancer. Aminoacid metabolic reprograming is essential to satisfy the different requirements of cancer cells during drug resistance,of which serine ...
Kailing Pan, Xiaoya Zhao, Wenxia Xu
doaj +1 more source
Experimental Cell Research, 2023 The Warburg effect links growth and glycolysis in cancer. A key purpose of the Warburg effect is to generate glycolytic intermediates for anabolic reactions, such as nucleotides → RNA/DNA and amino acids → protein synthesis.
L. Stadhouders +13 more
semanticscholar +1 more source
Renal UTX-PHGDH-serine axis regulates metabolic disorders in the kidney and liver
Nature Communications, 2022 Chen et al. report on a renal UTX-phosphoglycerate dehydrogenase axis that regulates serine secretion to affect lipid metabolism in the kidney and liver upon over-nutrition, suggesting potential treatment targets for obesity-related diseases.
Hong Chen +15 more
doaj +1 more source
Nature Communications, 2023 The role of protein arginine methylation in serine metabolism of cancer cells in hepatocellular carcinoma (HCC) remains to be explored. Here, the authors show that phosphoglycerate dehydrogenase (PHGDH) is activated by PRMT1-mediated R236 methylation ...
Kui Wang +13 more
doaj +1 more source
Lactate Limits T Cell Proliferation via the NAD(H) Redox State
Cell Reports, 2020 Summary: Immune cell function is influenced by metabolic conditions. Low-glucose, high-lactate environments, such as the placenta, gastrointestinal tract, and the tumor microenvironment, are immunosuppressive, especially for glycolysis-dependent effector
William J. Quinn, III +22 more
doaj +1 more source
, 2010 African trypanosomes have emerged as promising unicellular model organisms for the next generation of systems biology. They offer unique advantages, due to their relative simplicity, the availability of all standard genomics techniques and a long history
BARBARA M. BAKKER +10 more
core +8 more sources