Results 41 to 50 of about 171,288 (210)

Neurotransmitters in 3-phosphoglycerate dehydrogenase deficiency

European Journal of Pediatrics, 2000
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Koning, T.J., Duran, M., Dorland, L., Jakobs, C., Wevers, R.A., Berger, R.A., Poll-The, B.T.   +6 more
openaire   +5 more sources

High expression of phosphoglycerate dehydrogenase predicts poor outcome in patients with high-grade serous ovarian cancer. [PDF]

Oncologist
INTRODUCTION: High-grade serous ovarian cancer (HGSOC) is characterized by high mortality and prevalent recurrences. This study investigates the prognostic value of phosphoglycerate dehydrogenase (PHGDH) in HGSOC which has been linked to metabolic ...
van Wagensveld L, Van Nyen T, Annibali D, Sonke GS, Kruitwagen RFPM, Amant F, Horlings HM.   +6 more
europepmc   +2 more sources

Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor BI-4924 Disrupts Serine Biosynthesis

, 2019
Phosphoglycerate dehydrogenase (PHGDH) is known to be the rate-limiting enzyme in the serine synthesis pathway in humans. It converts glycolysis-derived 3-phosphoglycerate to 3-phosphopyruvate in a co-factor-dependent oxidation reaction.
Peter Ettmayer (3013665), Stephan K. Zahn (3030174), Michelle Burkard (7245791), Harald Weinstabl (2078782), Biljana Peric-Simov (2444032), Jens Quant (7245815), Moriz Mayer (1947241), Géraldine Garavel (7245773), Heribert Arnhof (1947235), Jens Bruchhaus (7245788), Xuechun Zhang (7245809), Fabio Savarese (70678), Darryl B. McConnell (2685361), Karin S. Hofbauer (7245770), Mark Pearson (278362), Andreas Schrenk (6388715), Christoph Harrer (7245803), Dirk Kessler (2556022), Daniela Haering (7245806), Joerg Rinnenthal (6388709), Klaus Rumpel (2436175), Nikolai Mischerikow (2339824), Andreas Zoephel (2556019), Georg Dahmann (2046736), Sophie Mitzner (7245779), Xiaobing Lv (4810647), Yvonne Scherbantin (7245776), Dongyang Li (2203135), Yali Li (198373), Thomas N. Fett (7245782), Gerd Bader (2556040), Tuncay Ciftci (7245797), Matthias Treu (7245767), Alicia Du (7245812), Renate Schnitzer (3346640), Guido Scholz (7245785), Paola Martinelli (122001), Bernhard Wolkerstorfer (4481332), Wolfgang Sommergruber (30929), Thomas Gerstberger (2556016), Roland Kousek (7245794), Bernadette Sharps (7245800)   +41 more
core   +3 more sources

Transient Glycolytic Complexation of Arsenate Enhances Resistance in the Enteropathogen Vibrio cholerae

mBio, 2022
The ubiquitous presence of toxic arsenate (AsV) in the environment has raised mechanisms of resistance in all living organisms. Generally, bacterial detoxification of AsV relies on its reduction to arsenite (AsIII) by ArsC, followed by the export of ...
Emilio Bueno, Víctor Pinedo, Dhananjay D. Shinde, André Mateus, Athanasios Typas, Mikhail M. Savitski, Vinai C. Thomas, Felipe Cava   +7 more
doaj   +1 more source

3-PGDH Deficiency, Seizures, and Microcephaly

Pediatric Neurology Briefs, 1998
The beneficial effects of oral L-serine (up to 500 mg/kg/day) and glycine (200 mg/kg/day) in 2 siblings, aged 7 and 5 years, with 3-phosphoglycerate dehydrogenase (3-PGDH) deficiency are reported from University Children’s Hospital, Utrecht, The ...
J Gordon Millichap
doaj   +1 more source

The activation of 3‐phosphoglycerate dehydrogenase by L‐methionine [PDF]

FEBS Letters, 1970
Feedback inhibition within the metabolic pathways leading to amino acid biosynthesis is well known in a variety of organisms including higher plants [ 1,2] . Most of the information refers to the effects of amino acids on their own biosynthesis but Jensen [3] has recently pointed out that a regulatory superstructure connecting various metabolic ...
openaire   +2 more sources

Expressions and roles of key enzymes in serine synthesis pathway in NaAsO2-treated HaCaT cells

环境与职业医学, 2022
BackgroundThe key enzymes of serine synthesis pathway (SSP) play an important role in tumor growth, proliferation, and invasion, but their roles in arsenic carcinogenesis are unclear.ObjectiveTo observe the effects of NaAsO2 treatment on the expressions ...
Fengmin LI, Jinmei HAN, Hongqian HUANG, Na WANG, Aihua ZHANG, Xue HAN   +5 more
doaj   +1 more source

Phosphoglycerate Dehydrogenase: Potential Therapeutic Target and Putative Metabolic Oncogene [PDF]

, 2015
Exemplified by cancer cells' preference for glycolysis, for example, the Warburg effect, altered metabolism in tumorigenesis has emerged as an important aspect of cancer in the past 10–20 years.
Zogg, Cheryl K.
core   +1 more source

Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC

Nature Communications, 2019
Resistance to the tyrosine kinase inhibitor Sorafenib, which is the standard treatment for advanced hepatocellular carcinoma, is a major clinical challenge.
Lai Wei, Derek Lee, Cheuk-Ting Law, Misty Shuo Zhang, Jialing Shen, Don Wai-Ching Chin, Allen Zhang, Felice Ho-Ching Tsang, Ceci Lok-Sze Wong, Irene Oi-Lin Ng, Carmen Chak-Lui Wong, Chun-Ming Wong   +11 more
doaj   +1 more source

Phosphoserine Aminotransferase1 Is Part of the Phosphorylated Pathways for Serine Biosynthesis and Essential for Light and Sugar-Dependent Growth Promotion

Frontiers in Plant Science, 2018
The phosphorylated pathway of serine biosynthesis represents an important pathway in plants. The pathway consist of three reactions catalyzed by the phosphoglycerate dehydrogenase, the phosphoserine aminotransferase and the phosphoserine phosphatase, and
Sabine Wulfert, Stephan Krueger
doaj   +1 more source