Results 21 to 30 of about 171,288 (210)

Structure–Activity Relationships (SARs) of α-Ketothioamides as Inhibitors of Phosphoglycerate Dehydrogenase (PHGDH) [PDF]

Pharmaceuticals, 2020
For many years now, targeting deregulation within cancer cells’ metabolism has appeared as a promising strategy for the development of more specific and efficient cancer treatments.
Quentin Spillier, Séverine Ravez, Judith Unterlass, Cyril Corbet, Charline Degavre, Olivier Feron, Raphaël Frédérick   +6 more
doaj   +2 more sources

Expanding the clinical spectrum of 3‐phosphoglycerate dehydrogenase deficiency [PDF]

Journal of Inherited Metabolic Disease, 2010
Abstract3‐Phosphoglycerate dehydrogenase (3‐PGDH) deficiency is considered to be a rare cause of congenital microcephaly, infantile onset of intractable seizures and severe psychomotor retardation. Here, we report for the first time a very mild form of genetically confirmed 3‐PGDH deficiency in two siblings with juvenile onset of absence seizures and ...
Tabatabaie, L., Klomp, L. W. J., Rubio-Gozalbo, M. E., Spaapen, L. J. M., Haagen, A. A. M., Dorland, L., de Koning, T.J.   +6 more
openaire   +6 more sources

Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E [PDF]

Journal of Experimental & Clinical Cancer Research, 2019
Background Pancreatic cancer is one of the most malignant cancers. The overall 5-year survival rate of its patients is 8%, the lowest among major cancer types.
Xuhui Ma, Boya Li, Jie Liu, Yan Fu, Yongzhang Luo   +4 more
doaj   +2 more sources

Phosphoglycerate dehydrogenase stabilizes protein kinase C delta type mRNA to promote hepatocellular carcinoma progression [PDF]

Signal Transduction and Targeted Therapy
Metabolic reprogramming not only reshapes cellular bioenergetics but also profoundly influences RNA metabolism through metabolite signaling and the RNA-binding activities of metabolic enzymes.
Bin Cheng, Pai Peng, Shi Chen, Rui Liu, Xiaosong Li, Ke Wang, Jing Ma, Kai Wang, Ni Tang, Ailong Huang   +9 more
doaj   +2 more sources

Ser3p (Yer081wp) and Ser33p (Yil074cp) Are Phosphoglycerate Dehydrogenases in Saccharomyces cerevisiae [PDF]

Journal of Biological Chemistry, 2003
Two genes YER081W and YIL074C, renamed SER3 and SER33, respectively, which encode phosphoglycerate dehydrogenases in Saccharomyces cerevisiae were identified. These dehydrogenases catalyze the first reaction of serine and glycine biosynthesis from the glycolytic metabolite 3-phosphoglycerate. Unlike either single mutant, the ser3Delta ser33Delta double
Albers, E., Laizé, Vincent, Blomberg, A., Hohmann, S., Gustafsson, L.   +4 more
openaire   +4 more sources

3-Phosphoglycerate dehydrogenase: a potential target for cancer treatment. [PDF]

Cell Oncol (Dordr), 2021
Metabolic changes have been recognized as an important hallmark of cancer cells. Cancer cells can promote their own growth and proliferation through metabolic reprogramming. Particularly, serine metabolism has frequently been reported to be dysregulated in tumor cells.
Li M, Wu C, Yang Y, Zheng M, Yu S, Wang J, Chen L, Li H.   +7 more
europepmc   +4 more sources

The Role of D-3-Phosphoglycerate Dehydrogenase in Cancer. [PDF]

Int J Biol Sci, 2020
Serine, a non-essential amino acid, can be imported from the extracellular environment by transporters and de novo synthesized from glycolytic 3-phosphoglycerate (3-PG) in the serine biosynthetic pathway (SSP). It has been reported that active serine synthesis might be needed for the synthesis of proteins, lipids, and nucleotides and the balance of ...
Zhao X, Fu J, Du J, Xu W.
europepmc   +4 more sources

On the quaternary structure of human D-3-phosphoglycerate dehydrogenase. [PDF]

Protein Sci
AbstractD‐3‐phosphoglycerate dehydrogenase (PHGDH) catalyzes the NAD+‐dependent conversion of D‐3‐phospho‐glycerate to 3‐phosphohydroxypyruvate, the first step in the phosphorylated pathway for L‐serine (L‐Ser) biosynthesis. L‐Ser plays different relevant metabolic roles in eukaryotic cells: alterations in L‐Ser metabolism have been linked to serious ...
Riva D, Orlando M, Rabattoni V, Pollegioni L.   +3 more
europepmc   +4 more sources

Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate. [PDF]

ACS Chem Biol, 2015
: Human D-3-phosphoglycerate dehydrogenase (PHGDH), the first enzyme in the serine biosynthetic pathway, is genomically amplified in tumors including breast cancer and melanoma.
Fan J, Fan J, Teng X, Liu L, Mattaini KR, Looper RE, Vander Heiden MG, Rabinowitz JD.   +7 more
europepmc   +3 more sources

Phosphoglycerate dehydrogenase genes differentially affect Arabidopsis metabolism and development [PDF]

, 2021
[EN] Unlike animals, plants possess diverse L-serine (Ser) biosynthetic pathways. One of them, the Phosphorylated Pathway of Serine Biosynthesis (PPSB) has been recently described as essential for embryo, pollen and root development, and required for ...
Rosa-Tellez, Sara, Fernie, Alisdair R., Ros, Roc, Casatejada-Anchel, Rubén, Anoman, Armand D., Torres-Moncho, Alejandro, Muñoz-Bertomeu, Jesús, Nebauer, Sergio G.   +7 more
core   +2 more sources