Results 21 to 30 of about 23,057 (164)
Biochemical and Biophysical Characterization of Recombinant Human 3-Phosphoglycerate Dehydrogenase. [PDF]
Int J Mol Sci, 2021 The human enzyme D-3-phosphoglycerate dehydrogenase (hPHGDH) catalyzes the reversible dehydrogenation of 3-phosphoglycerate (3PG) into 3-phosphohydroxypyruvate (PHP) using the NAD+/NADH redox cofactor, the first step in the phosphorylated pathway producing L-serine.
Murtas G +4 more
europepmc +5 more sources
The Global mRNA Expression Profiles of Inhibiting PHGDH Induced Cisplatin Resistance in Gastric Cancer [PDF]
Cell Journal, 2022 Objective: Drug resistance is the main hindrance to improve the prognosis of patients with gastric cancer. Aminoacid metabolic reprograming is essential to satisfy the different requirements of cancer cells during drug resistance,of which serine ...
Kailing Pan, Xiaoya Zhao, Wenxia Xu
doaj +1 more source
On the quaternary structure of human D-3-phosphoglycerate dehydrogenase. [PDF]
Protein SciAbstractD‐3‐phosphoglycerate dehydrogenase (PHGDH) catalyzes the NAD+‐dependent conversion of D‐3‐phospho‐glycerate to 3‐phosphohydroxypyruvate, the first step in the phosphorylated pathway for L‐serine (L‐Ser) biosynthesis. L‐Ser plays different relevant metabolic roles in eukaryotic cells: alterations in L‐Ser metabolism have been linked to serious ...
Riva D +3 more
europepmc +4 more sources
Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis [PDF]
American Journal of Respiratory Cell and Molecular Biology, 2018 Robert B Hamanaka +2 more
exaly +2 more sources
Renal UTX-PHGDH-serine axis regulates metabolic disorders in the kidney and liver
Nature Communications, 2022 Chen et al. report on a renal UTX-phosphoglycerate dehydrogenase axis that regulates serine secretion to affect lipid metabolism in the kidney and liver upon over-nutrition, suggesting potential treatment targets for obesity-related diseases.
Hong Chen +15 more
doaj +1 more source
Nature Communications, 2023 The role of protein arginine methylation in serine metabolism of cancer cells in hepatocellular carcinoma (HCC) remains to be explored. Here, the authors show that phosphoglycerate dehydrogenase (PHGDH) is activated by PRMT1-mediated R236 methylation ...
Kui Wang +13 more
doaj +1 more source
Lactate Limits T Cell Proliferation via the NAD(H) Redox State
Cell Reports, 2020 Summary: Immune cell function is influenced by metabolic conditions. Low-glucose, high-lactate environments, such as the placenta, gastrointestinal tract, and the tumor microenvironment, are immunosuppressive, especially for glycolysis-dependent effector
William J. Quinn, III +22 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 The small-molecule inhibitor of phosphoglycerate dehydrogenase, NCT-503, reduces incorporation of glucose-derived carbons into serine in vitro.
Birte Arlt +6 more
doaj +1 more source
Targeting one-carbon metabolism requires mTOR inhibition: a new therapeutic approach in osteosarcoma
Molecular & Cellular Oncology, 2021 The rate-limiting enzyme of serine biosynthesis, 3-phosphoglycerate dehydrogenase (PHGDH), contributes to rapid growth and proliferation when it is overexpressed in cancer.
Richa Rathore, Brian Van Tine
doaj +1 more source
3-phosphoglycerate dehydrogenase gene polymorphism amongst patients with thyroid gland cancer [PDF]
Medicinski Podmladak, 2016 Introduction: Thyroid gland cancer is a rare malignancy in the male population, accounting for up to 2% of all cancers, but it is the most common cancer of the endocrine system, making up to 95% of all estimated new endocrine cancer cases each year ...
Pjevalica Jelena +2 more
doaj +1 more source