High Phosphoglycerate Dehydrogenase Expression Induces Stemness and Aggressiveness in Thyroid Cancer [PDF]
Thyroid, 2020 Min Ji Jeon +2 more
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3-Phosphoglycerate dehydrogenase: a potential target for cancer treatment. [PDF]
Cell Oncol (Dordr), 2021 Metabolic changes have been recognized as an important hallmark of cancer cells. Cancer cells can promote their own growth and proliferation through metabolic reprogramming. Particularly, serine metabolism has frequently been reported to be dysregulated in tumor cells.
Li M +7 more
europepmc +4 more sources
Prognostic value of serum phosphoglycerate dehydrogenase and glycine levels in breast cancer [PDF]
Menopause ReviewHussam Abd Jassem, Anwar Jasib Thaaban
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The Role of D-3-Phosphoglycerate Dehydrogenase in Cancer. [PDF]
Int J Biol Sci, 2020 Serine, a non-essential amino acid, can be imported from the extracellular environment by transporters and de novo synthesized from glycolytic 3-phosphoglycerate (3-PG) in the serine biosynthetic pathway (SSP). It has been reported that active serine synthesis might be needed for the synthesis of proteins, lipids, and nucleotides and the balance of ...
Zhao X, Fu J, Du J, Xu W.
europepmc +4 more sources
Correction: Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E [PDF]
Journal of Experimental & Clinical Cancer ResearchXuhui Ma +4 more
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The Global mRNA Expression Profiles of Inhibiting PHGDH Induced Cisplatin Resistance in Gastric Cancer [PDF]
Cell Journal, 2022 Objective: Drug resistance is the main hindrance to improve the prognosis of patients with gastric cancer. Aminoacid metabolic reprograming is essential to satisfy the different requirements of cancer cells during drug resistance,of which serine ...
Kailing Pan, Xiaoya Zhao, Wenxia Xu
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Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate. [PDF]
ACS Chem Biol, 2015 : Human D-3-phosphoglycerate dehydrogenase (PHGDH), the first enzyme in the serine biosynthetic pathway, is genomically amplified in tumors including breast cancer and melanoma.
Fan J +7 more
europepmc +3 more sources
Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis [PDF]
American Journal of Respiratory Cell and Molecular Biology, 2018 Nickolai Dulin, Robert Guzy, Mutlu Gm
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On the quaternary structure of human D-3-phosphoglycerate dehydrogenase. [PDF]
Protein SciAbstractD‐3‐phosphoglycerate dehydrogenase (PHGDH) catalyzes the NAD+‐dependent conversion of D‐3‐phospho‐glycerate to 3‐phosphohydroxypyruvate, the first step in the phosphorylated pathway for L‐serine (L‐Ser) biosynthesis. L‐Ser plays different relevant metabolic roles in eukaryotic cells: alterations in L‐Ser metabolism have been linked to serious ...
Riva D +3 more
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Renal UTX-PHGDH-serine axis regulates metabolic disorders in the kidney and liver
Nature Communications, 2022 Chen et al. report on a renal UTX-phosphoglycerate dehydrogenase axis that regulates serine secretion to affect lipid metabolism in the kidney and liver upon over-nutrition, suggesting potential treatment targets for obesity-related diseases.
Hong Chen +15 more
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