Results 11 to 20 of about 5,503 (166)
Multi-omics Analysis of the Role of PHGDH in Colon Cancer
Technology in Cancer Research and Treatment, 2023 Objectives : Serine metabolism is essential for tumor cells. Endogenous serine arises from de novo synthesis pathways. As the rate-limiting enzyme of this pathway, PHGDH is highly expressed in a variety of tumors including colon cancer.
Jinlin Du, Xing Chungen, Yunqing Qiu
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Molecular glue triggers degradation of PHGDH by enhancing the interaction between DDB1 and PHGDH
Acta Pharmaceutica Sinica BCancer stem cells (CSCs) play a pivotal role in tumor initiation, proliferation, metastasis, drug resistance, and recurrence. Consequently, targeting CSCs has emerged as a promising avenue for cancer therapy.
Guang Yang, Zhang Kun, Shuangwei Liu
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m6A modification and SUMOylation of PHGDH regulates ulcerative colitis through autophagy [PDF]
Cellular and Molecular Life SciencesBackground Ulcerative colitis (UC) is a chronic inflammatory bowel disorder with increasing incidence globally. However, the understanding of UC pathogenesis remains limited. Methods DSS-induced UC mouse model and lipopolysaccharide (LPS)-treated colonic
Hui Xue +5 more
doaj +4 more sources
PHGDH at the crossroads: metabolic plasticity, metastatic paradoxes, and therapeutic reconnaissance in cancer [PDF]
Journal of Biomedical SciencePhosphoglycerate dehydrogenase (PHGDH), the rate-limiting enzyme of the serine biosynthesis pathway (SSP), is a central metabolic hub and multifunctional oncoprotein that drives tumorigenesis through both canonical and non-canonical mechanisms.
Liang Hao +6 more
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PHGDH Defines a Metabolic Subtype in Lung Adenocarcinomas with Poor Prognosis [PDF]
Cell Reports, 2017 Molecular signatures are emerging determinants of choice of therapy for lung adenocarcinomas. An evolving therapeutic approach includes targeting metabolic dependencies in cancers.
Helin Vakifahmetoglu-Norberg +2 more
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Advanced Science, 2023 Herein, we observed that nuclear localization of phosphoglycerate dehydrogenase (PHGDH) is associated with poor prognosis in liver cancer, and Phgdh is required for liver cancer progression in a mouse model.
Xiongjun Wang
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Increased PHGDH expression promotes aberrant melanin accumulation [PDF]
BMC Cancer, 2019 Background Copy number gain of the D-3-phosphoglycerate dehydrogenase (PHGDH) gene, which encodes the first enzyme in serine biosynthesis, is found in some human cancers including a subset of melanomas.
Katherine R. Mattaini +5 more
doaj +3 more sources
Molecular Oncology, 2020 d‐3‐Phosphoglycerate dehydrogenase (PHGDH) conducts an important step in the synthesis of serine. Importantly, the PHGDH gene is often amplified in certain cancers.
Masaya Yonemori +2 more
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Molecules, 2022 Targeting the serine biosynthesis pathway enzymes has turned up as a novel strategy for anti-cancer therapeutics. 3- Phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme that catalyzes the conversion of 3-Phosphoglyceric acid (3-PG) into 3 ...
Rasul A, , Mudassir Hassan
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PHGDH-dependent serine metabolism in astrocytes: A key regulator of oxidative stress and pyroptosis in cerebral ischemia-reperfusion injury [PDF]
Redox BiologyPhosphoglycerate dehydrogenase (PHGDH) is a key molecule in the progression of Alzheimer's disease. Herein, we report that PHGDH exerts a significant influence on cerebral ischemia-reperfusion injury (CIRI).
Jimeng Zhang +15 more
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