Results 11 to 20 of about 6,588 (185)
Increased PHGDH expression promotes aberrant melanin accumulation [PDF]
BMC Cancer, 2019 Background Copy number gain of the D-3-phosphoglycerate dehydrogenase (PHGDH) gene, which encodes the first enzyme in serine biosynthesis, is found in some human cancers including a subset of melanomas.
Katherine R. Mattaini +5 more
doaj +4 more sources
Macrophage-specific PHGDH protects against MAFLD by suppressing TAK1
Cell ReportsSummary: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a progressive disease with only one approved treatment currently available.
Penghui Hu +16 more
doaj +4 more sources
Increased Expression of PHGDH and Prognostic Significance in Colorectal Cancer
Translational Oncology, 2016 Phosphoglycerate dehydrogenase (PHGDH) plays an essential role in cancer-specific metabolic reprogramming. It has been reported as a putative metabolic oncogene in several types of human malignant tumors, such as breast cancer and melanoma.
Xiao-qin Jia +6 more
doaj +4 more sources
PHGDH: a novel therapeutic target in cancer
Experimental and Molecular MedicineSerine is a key contributor to the generation of one-carbon units for DNA synthesis during cellular proliferation. In addition, it plays a crucial role in the production of antioxidants that prevent abnormal proliferation and stress in cancer cells.
Chae Min Lee +5 more
doaj +4 more sources
Molecular glue triggers degradation of PHGDH by enhancing the interaction between DDB1 and PHGDH
Acta Pharmaceutica Sinica BCancer stem cells (CSCs) play a pivotal role in tumor initiation, proliferation, metastasis, drug resistance, and recurrence. Consequently, targeting CSCs has emerged as a promising avenue for cancer therapy.
Guang Yang, Zhang Kun, Jiefu Wang
exaly +5 more sources
PHGDH heterogeneity potentiates cancer cell dissemination and metastasis [PDF]
Nature, 2022 Cancer metastasis requires the transient activation of cellular programs enabling dissemination and seeding in distant organs1. Genetic, transcriptional and translational heterogeneity contributes to this dynamic process2,3. Metabolic heterogeneity has also been observed4, yet its role in cancer progression is less explored.
Matteo Rossi +50 more
core +8 more sources
Multi-omics Analysis of the Role of PHGDH in Colon Cancer
Technology in Cancer Research & Treatment, 2023 Objectives : Serine metabolism is essential for tumor cells. Endogenous serine arises from de novo synthesis pathways. As the rate-limiting enzyme of this pathway, PHGDH is highly expressed in a variety of tumors including colon cancer.
Zhihui Dai MSc +6 more
doaj +3 more sources
PHGDH as a mechanism for resistance in metabolically-driven cancers
Cancer Drug Resistance, 2020 At the forefront of cancer research is the rapidly evolving understanding of metabolic reprogramming within cancer cells. The expeditious adaptation to metabolic inhibition allows cells to evolve and acquire resistance to targeted treatments, which makes therapeutic exploitation complex but achievable.
Rathore, Richa +2 more
openaire +4 more sources
PHGDH expression increases with progression of Alzheimer’s disease pathology and symptoms [PDF]
Cell Metabolism, 2022 Chen et al. reveal an increase of phosphoglycerate dehydrogenase (PHGDH) mRNA and protein levels in two mouse models and four human cohorts in Alzheimer's disease brains compared to age- and sex-matched control brains. The increase of PHGDH expression in human brain correlates with symptomatic development and disease pathology.
Xu Chen +7 more
openaire +5 more sources
Differential expression of PHGDH in pancreatic cancer.
, 2023 Cancer is a leading cause of death and pancreatic cancer is among the most lethal cancers (1, 2). We mined published microarray datasets (3, 4) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with pancreatic cancer, pancreatic adenocarcinoma (PDAC).
Shahan Mamoor
openaire +2 more sources