Results 31 to 40 of about 8,172 (201)

Acetylation Stabilizes Phosphoglycerate Dehydrogenase by Disrupting the Interaction of E3 Ligase RNF5 to Promote Breast Tumorigenesis

Cell Reports, 2020
Summary: Phosphoglycerate dehydrogenase (PHGDH) is the first enzyme in the serine synthesis pathway in which it is also the rate-limiting enzyme. It is significantly upregulated in many cancers, especially breast cancer.
Chao Wang, Xingyou Wan, Tong Yu, Zhenyu Huang, Chao Shen, Qian Qi, Sheng Xiang, Xinyuan Chen, Eyal Arbely, Zhi-Qiang Ling, Chen-Ying Liu, Wei Yu   +11 more
doaj   +1 more source

Splicing factor ESRP1 controls ER-positive breast cancer by altering metabolic pathways [PDF]

, 2019
The epithelial splicing regulatory proteins 1 and 2 (ESRP1 and ESRP2) control the epithelial-to-mesenchymal transition (EMT) splicing program in cancer. However, their role in breast cancer recurrence is unclear. In this study, we report that high levels
Badve, Sunil S., Goswami, Chirayu P., Gu, Xiaoping, Gu, Yuan, Gökmen‐Polar, Yesim, Janga, Sarath C., Nallamothu, Gouthami, Neelamraju, Yaseswini, Ryan, Michael, Vieth, Edyta   +9 more
core   +1 more source

An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation [PDF]

, 2015
Background The gene encoding the serine biosynthesis pathway enzyme PHGDH is located in a region of focal genomic copy number gain in human cancers. Cells with PHGDH amplification are dependent on enzyme expression for proliferation. However, dependence
Brignole, Edward J, Davidson, Shawn Michael, Drennan, Catherine L, Fiske, Brian Prescott, Kini, Mitali, Mattaini, Katherine Ruth, Vander Heiden, Matthew G.   +6 more
core   +1 more source

Serine biosynthesis defect due to haploinsufficiency of PHGDH causes retinal disease [PDF]

Nature Metabolism, 2021
Macular telangiectasia type 2 (MacTel) is a progressive, late-onset retinal degenerative disease linked to decreased serum levels of serine that elevate circulating levels of a toxic ceramide species, deoxysphingolipids (deoxySLs); however, causal genetic variants that reduce serine levels in patients have not been identified.
Kevin Eade, Marin L. Gantner, Joseph A. Hostyk, Takayuki Nagasaki, Sarah Giles, Regis Fallon, Sarah Harkins-Perry, Michelle Baldini, Esther W. Lim, Lea Scheppke, Michael I. Dorrell, Carolyn Cai, Evan H. Baugh, Charles J. Wolock, Martina Wallace, Rebecca B. Berlow, David B. Goldstein, Christian M. Metallo, Martin Friedlander, Rando Allikmets   +19 more
openaire   +2 more sources

One-carbon metabolism in cancer [PDF]

, 2017
Cells require one-carbon units for nucleotide synthesis, methylation and reductive metabolism, and these pathways support the high proliferative rate of cancer cells.
AJ MacFarlane, Alice C Newman, AS Tibbetts, B Chaneton, BC Blount, C Commisso, CA Lewis, CF Labuschagne, CF Woeller, D Hanahan, D Hanahan, D Kim, DD Anderson, E Currie, E Mullarky, F Daidone, F Kottakis, G Kikuchi, GM DeNicola, Gregory S. Ducker, GS Ducker, J Liu, J Meiser, J Ye, Jason W. Locasale, JJ Kamphorst, JW Locasale, K Snell, K Snell, K Snell, Katherine R. Mattaini, L Galluzzi, M Goulian, M Jain, M Kulis, Mahya Mehrmohamadi, ME Pacold, Ming Yang, MJ Osborn, ML Rose, ML Rose, OD Maddocks, OD Maddocks, Oliver D K Maddocks, Oliver D. K. Maddocks, PM Ueland, R Possemato, S Farber, S Kit, S Pollari, SJ Mentch, Swetha Bolusani, T Shlomi, WC Zhang, Y Fu, Z Ser   +55 more
core   +1 more source

Targeting phosphoglycerate dehydrogenase in multiple myeloma

Experimental Hematology & Oncology, 2021
Background Multiple myeloma (MM) is a hematological malignancy characterized by the clonal expansion of plasma cells in the bone marrow. To date, this disease is still incurable and novel therapeutic approaches are required.
Samah Elsaadi, Ida Steiro, Pegah Abdollahi, Esten N. Vandsemb, Rui Yang, Tobias S. Slørdahl, Torstein Baade Rø, Eline Menu, Anne-Marit Sponaas, Magne Børset   +9 more
doaj   +1 more source

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor. [PDF]

, 2016
Cellular amino acid uptake is critical for mTOR complex 1 (mTORC1) activation and cell proliferation. However, the regulation of amino acid uptake is not well-understood.
Braas, Daniel, Christofk, Heather R, Graeber, Thomas G, Krall, Abigail S, Xu, Shili   +4 more
core   +1 more source

Functional genomics reveals serine synthesis is essential in PHGDH-amplified breast cancer [PDF]

, 2010
Cancer cells adapt their metabolic processes to drive macromolecular biosynthesis for rapid cell growth and proliferation[superscript 1, 2]. RNA interference (RNAi)-based loss-of-function screening has proven powerful for the identification of new and ...
A Bric, A Marson, Abhishek K. Jha, Albert M. Chan, B Luo, Bingbing Yuan, D Wiederschain, DA Walsh, David E. Root, David M. Sabatini, Dohoon Kim, DR Rhodes, Edward M. Driggers, Elena F. Brachtel, FR Miller, FR Miller, Francesca G. Barrett, Glenn S. Cowley, Hin-Koon Woo, Hyun G. Jang, I Ben-Porath, J Debnath, J Kim, J Moffat, JM Buescher, Jordi Barretina, K Lund, K Snell, Kathleen Ottina, Kevin M. Marks, Kıvanç Birsoy, Levi A. Garraway, Mari Mino-Kenudson, Michael E. Pacold, MJ van de Vijver, Nada Y. Kalaany, Nicolas Stransky, NY Kalaany, Peggy P. Hsu, PP Hsu, R Beroukhim, RG Jones, Richard Possemato, RJ DeBerardinis, S Pollari, Shalini Sethumadhavan, TS Mikkelsen, Walter W. Chen, WE Knox, Y Achouri, Y Sancak, Yoav D. Shaul, Zhi-Yang Tsun   +52 more
core   +1 more source

PHGDH Is Upregulated at Translational Level and Implicated in Platin-Resistant in Ovarian Cancer Cells

Frontiers in Oncology, 2021
BackgroundPlatinum-based chemotherapy is the first line option for ovarian cancer. The development of resistance to such chemotherapy results in treatment failure, while the underlying mechanisms are poorly understood.MethodsClinical samples were ...
Fangfang Bi, Yuanyuan An, Tianshui Sun, Yue You, Qing Yang   +4 more
doaj   +1 more source

Cancer metabolism: Addicted to serine. [PDF]

, 2016
Cancer cells are biosynthetic factories that gear multiple metabolic pathways toward cell growth and proliferation. Serine is the metabolite consumed third most by cancer cells, after glucose and glutamine, and is used as a building block for proteins ...
Frezza, Christian
core   +2 more sources