Results 31 to 40 of about 6,588 (185)

XPR1 downregulation inhibits hepatocellular carcinoma progression by suppressing serine metabolism [PDF]

Redox Biology
Xenotropic and polytropic retrovirus receptor 1 (XPR1) is highly expressed in various tumors and is associated with poor clinical prognosis, making it a proposed therapeutic target for cancer. However, the mechanism of XPR1 in tumorigenesis, particularly
Zi-qiang Liao, Ze-ning Chen, Yang-feng Lv, Yuan-yuan Zhang, Zhi-xing Liu, Zhi-qiang Deng, Qing-rong Liang, Chun-bo Zhang, Qun Tang   +8 more
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PHGDH inhibition and FOXO3 modulation drives PUMA-dependent apoptosis in osteosarcoma [PDF]

Cell Death and Disease
Osteosarcoma is a bone cancer that has been found to be metabolically dependent on the conversion of glucose to serine through the rate-limiting enzyme 3-phosphoglycerate dehydrogenase (PHGDH).
Toshinao Oyama, Caitlyn B. Brashears, Richa Rathore, Heather Benect-Hamilton, Katharine E. Caldwell, Naomi Dirckx, William G. Hawkins, Brian A. Van Tine   +7 more
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The role of PHGDH in hypoxic adaptation and metabolic reprogramming

Hypoxia is a common feature of solid tumours and is associated with poor prognosis and resistance to therapy. Attempts to therapeutically target hypoxic tumour cells have shown limited clinical success. This thesis investigates the role of phosphoglycerate dehydrogenase (PHGDH), the rate-limiting enzyme of the serine synthesis pathway (SSP), in hypoxic
openaire   +2 more sources

PHGDH regulates dendritic cell immune crosstalk 2267410

The Journal of Immunology
Abstract Introduction Conventional dendritic cells (cDCs) play a unique role in immunoregulation and antigen presentation, which is fundamental to protective immunity and is implicated in various autoimmune pathologies.
Ebenezer Asiedu, Connie Krawczyk
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MAPK13 phosphorylates PHGDH and promotes its degradation via chaperone-mediated autophagy during liver injury

Cell Discovery
Drug-induced liver injury (DILI) is the leading cause of acute liver failure and poses a significant clinical challenge in both diagnosis and treatment.
Ru Xing, Ruilong Liu, Yongxiao Man, Chen Liu, Yajuan Zhang, Hong Gao, Weiwei Yang   +6 more
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Identification of a novel PHGDH covalent inhibitor by chemical proteomics and phenotypic profiling

Acta Pharmaceutica Sinica B, 2022
The first rate-limiting enzyme of the serine synthesis pathway (SSP), phosphoglycerate dehydrogenase (PHGDH), is hyperactive in multiple tumors, which leads to the activation of SSP and promotes tumorigenesis. However, only a few inhibitors of PHGDH have
Chen Chen, Tianyu Zhu, Xiaoqin Liu, Dongrong Zhu, Yi Zhang, Sifang Wu, Chao Han, Hao Zhang, Jianguang Luo, Lingyi Kong   +9 more
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Phosphoglycerate dehydrogenase positively regulates the proliferation of chicken muscle cells

Poultry Science, 2022
: Phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme in the serine synthesis pathway. However, the regulatory role of PHGDH in muscle development is unclear.
Han Wang, Moran Hu, Zhaoxue Ding, Xiaolong Zhou, Songbai Yang, Zhonghao Shen, Feifei Yan, Ayong Zhao   +7 more
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Comprehensive analysis of PHGDH for predicting prognosis and immunotherapy response in patients with endometrial carcinoma

BMC Medical Genomics, 2023
Background PHGDH (Phosphoglycerate Dehydrogenase) is the first branch enzyme in the serine biosynthetic pathway and plays a vital role in several cancers. However, little is known about the clinical significance of PHGDH in endometrial cancer.
He Zhang, Weimin Kong, Xiaoling Zhao, Yunkai Xie, Dan Luo, Shuning Chen   +5 more
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Phgdh acted as another tipping point signature.

, 2023
Related to Fig 4. (A) The schematic diagram showing the in vitro flow assay in Cas9 expressing HSPCs infected with Myc-GFP and sgRNA-mCherry. (B) T7 endonuclease I assay showed the sgNpm1/Phgdh efficiency in c-Kit+ cells derived from Cas9 expressing ...
Chong Chen (360710), Chengjian Zhao (348362), Xuelan Chen (9134204), Jing Xu (15337), Xintong Deng (15390503), Zhongwang Wang (6796082), Jian Wang (5901), Mei Chen (197360), Ting Niu (136108), Yuan Wang (14955), Lu Chen (75170), Shujun Li (176557), Dan Liao (288562), Jingwen Lin (9084200), Zhihong Xue (288022), Xiangyu Pan (10270598), Yu Liu (6938), Baohong Wu (15390500)   +17 more
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Acetylation Stabilizes Phosphoglycerate Dehydrogenase by Disrupting the Interaction of E3 Ligase RNF5 to Promote Breast Tumorigenesis

Cell Reports, 2020
Summary: Phosphoglycerate dehydrogenase (PHGDH) is the first enzyme in the serine synthesis pathway in which it is also the rate-limiting enzyme. It is significantly upregulated in many cancers, especially breast cancer.
Chao Wang, Xingyou Wan, Tong Yu, Zhenyu Huang, Chao Shen, Qian Qi, Sheng Xiang, Xinyuan Chen, Eyal Arbely, Zhi-Qiang Ling, Chen-Ying Liu, Wei Yu   +11 more
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