Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis. [PDF]
, 2020 Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability.
Coras, Roxana +2 more
core +2 more sources
A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate [PDF]
, 2015 Serine is a both a proteinogenic amino acid and the source of one-carbon units essential for de novo purine and deoxythymidine synthesis. In the canonical glucose-derived serine synthesis pathway, Homo sapiens phosphoglycerate dehydrogenase (PHGDH ...
Abu-Remaileh, Monther +16 more
core +1 more source
Modeling cancer metabolism on a genome scale [PDF]
, 2015 Cancer cells have fundamentally altered cellular metabolism that is associated with their tumorigenicity and malignancy. In addition to the widely studied Warburg effect, several new key metabolic alterations in cancer have been established over the last
Barbara Chaneton +8 more
core +1 more source
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis [PDF]
, 2010 Most tumors exhibit increased glucose metabolism to lactate, however, the extent to which glucose-derived metabolic fluxes are used for alternative processes is poorly understood [1, 2].
Adam J Bass +56 more
core +1 more source
Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) and serine biosynthetic pathway genes are co-ordinately increased during anabolic agent-induced skeletal muscle growth [PDF]
, 2016 We aimed to identify novel molecular mechanisms for muscle growth during administration of anabolic agents. Growing pigs (Duroc/(Landrace/Large-White)) were administered Ractopamine (a beta-adrenergic agonist; BA; 20ppm in feed) or Reporcin (recombinant ...
A Bassols +58 more
core +3 more sources
eIF3i promotes colorectal cancer cell survival via augmenting PHGDH translation
Journal of Biological Chemistry, 2023 Translational regulation is one of the decisive steps in gene expression, and its dysregulation is closely related to tumorigenesis. Eukaryotic translation initiation factor 3 subunit i (eIF3i) promotes tumor growth by selectively regulating gene translation, but the underlying mechanisms are largely unknown.
Yaguang Zhang +12 more
openaire +2 more sources
Can small molecular inhibitors that stop de novo serine synthesis be used in cancer treatment?
Cell Death Discovery, 2021 To sustain their malignancy, tumour cells acquire several metabolic adaptations such as increased oxygen, glucose, glutamine, and lipids uptake. Other metabolic processes are also enhanced as part of tumour metabolic reprogramming, for example, increased
Megan Jessica McNamee +2 more
doaj +1 more source
Genome-wide analyses identify common variants associated with macular telangiectasia type 2 [PDF]
, 2017 Idiopathic juxtafoveal retinal telangiectasis type 2 (macular telangiectasia type 2; MacTel) is a rare neurovascular degenerative retinal disease. To identify genetic susceptibility loci for MacTel, we performed a genome-wide association study (GWAS ...
A Bringmann +113 more
core +1 more source
Metabolomic changes during cellular transformation monitored by metabolite-metabolite correlation analysis and correlated with gene expression. [PDF]
, 2015 To investigate metabolic changes during cellular transformation, we used a 1H NMR based metabolite-metabolite correlation analysis (MMCA) method, which permits analysis of homeostatic mechanisms in cells at the steady state, in an inducible cell ...
Griffiths, John R +7 more
core +7 more sources
Activation of Serine One-Carbon Metabolism by Calcineurin A beta 1 Reduces Myocardial Hypertrophy and Improves Ventricular Function [PDF]
, 2017 Background In response to pressure overload, the heart develops ventricular hypertrophy that progressively decompensates and leads to heart failure.
Acin-Perez, R +12 more
core +1 more source