Results 21 to 30 of about 6,588 (185)

PHGDH supports liver ceramide synthesis and sustains lipid homeostasis [PDF]

Cancer & Metabolism, 2020
Background d-3-phosphoglycerate dehydrogenase (PHGDH), which encodes the first enzyme in serine biosynthesis, is overexpressed in human cancers and has been proposed as a drug target.
Yun Pyo Kang, Aimee Falzone, Min Liu, Paloma González-Sánchez, Bo-Hyun Choi, Jonathan L. Coloff, James J. Saller, Florian A. Karreth, Gina M. DeNicola   +8 more
doaj   +3 more sources

PHGDH Is Upregulated at Translational Level and Implicated in Platin-Resistant in Ovarian Cancer Cells [PDF]

Frontiers in Oncology, 2021
BackgroundPlatinum-based chemotherapy is the first line option for ovarian cancer. The development of resistance to such chemotherapy results in treatment failure, while the underlying mechanisms are poorly understood.MethodsClinical samples were ...
Fangfang Bi, Yuanyuan An, Tianshui Sun, Yue You, Qing Yang   +4 more
doaj   +2 more sources

High Expression of PHGDH Predicts Poor Prognosis in Non–Small Cell Lung Cancer

Translational Oncology, 2016
Tumors have exceptionally high demands for energy and anabolism because of their rapid growth. The de novo serine synthesis pathway initiated by phosphoglycerate dehydrogenase (PHGDH) has been recognized as a hallmark of metabolic adaption in ...
Jinhong Zhu, Jianqun Ma, Xudong Wang, Tianjiao Ma, Shu Zhang, Wei Wang, Xiaoyu Zhou, Jiahai Shi   +7 more
doaj   +2 more sources

PHGDH promotes the proliferation and differentiation of primary chicken myoblasts

British Poultry Science, 2022
1. Chicken primary myoblasts (CPMs) are precursors that form muscle fibres. The proliferation and differentiation of CPMs is an essential stage in muscle development. Previous RNA-seq analysis showed that phosphoglycerate dehydrogenase (PHGDH) is a differentially expressed gene in chicken muscle tissue at different growth stages.
L. Chen, Y. L. Wu, H. Ding, K. Z. Xie, T. Zhang, G. X. Zhang, J. Y. Wang   +6 more
openaire   +3 more sources

ZEB1 Transcriptionally Activates PHGDH to Facilitate Carcinogenesis and Progression of HCC

Cellular and Molecular Gastroenterology and Hepatology, 2023
Phosphoglycerate dehydrogenase (PHGDH), the rate-limiting enzyme of the de novo serine synthesis pathway (SSP), has been implicated in the carcinogenesis and metastasis of hepatocellular carcinoma (HCC) because of its excessive expression and promotion of SSP.
Huihui Wang, Furong Lin, Zhenzhen Xu, Shengnan Yu, Guannan Li, Shan Liao, Wentao Zhao, Fengqiong Zhang, Jinyang Wang, Shijie Wang, Cong Ouyang, Cixiong Zhang, Hailong Xia, Yufei Wu, Bin Jiang, Qinxi Li   +15 more
openaire   +4 more sources

Phosphoglycerate dehydrogenase (PHGDH) inhibitors: a comprehensive review 2015–2020

Expert Opinion on Therapeutic Patents, 2021
Introduction:The phosphoglycerate dehydrogenase (PHGDH), a metabolic enzyme involved in the serine synthetic pathway (SSP), appears to play a central role in supporting cancer growth and proliferation. PHGDH is a dehydrogenase whose expression in cancers was first demonstrated in 2010.
Quentin Spillier, Raphaël Frédérick
openaire   +3 more sources

YY2 mediates transcriptional repression of PHGDH and expedites oxidative stress in retinal pigment epithelial cells in diabetic retinopathy

Journal of Diabetes Investigation
Aims/Introduction Phosphoglycerate dehydrogenase (PHGDH), which controls serine synthesis, has been linked to retinal disease. However, there are no clues about its involvement in the diabetic retinopathy (DR) progression.
Xiang Lei, Xiu Wang, Xinai Zhang
doaj   +2 more sources

PHGDH at the crossroads: metabolic plasticity, metastatic paradoxes, and therapeutic reconnaissance in cancer [PDF]

Journal of Biomedical Science
Phosphoglycerate dehydrogenase (PHGDH), the rate-limiting enzyme of the serine biosynthesis pathway (SSP), is a central metabolic hub and multifunctional oncoprotein that drives tumorigenesis through both canonical and non-canonical mechanisms.
Liang Hao, Bai-Qiang Li, Shi-Yang Lu, Zhong-Cai An, Zheng-Yuan Yin, Zhen-Xian Du, Hua-Qin Wang   +6 more
doaj   +2 more sources

PHGDH activation fuels glioblastoma progression and radioresistance via serine synthesis pathway

Journal of Experimental & Clinical Cancer Research
Background Glioma stem-like cells (GSCs) are key drivers of treatment resistance and recurrence in glioblastoma (GBM). Phosphoglycerate dehydrogenase (PHGDH), a crucial enzyme in the de novo serine synthesis pathway (SSP), is implicated in tumorigenesis ...
Xiaojin Liu, Bangxin Liu, Junwen Wang, Hongbin Liu, Jiasheng Wu, Yiwei Qi, Yuan Liu, Hongtao Zhu, Chaoxi Li, Liu Yang, Jian Song, Guojie Yao, Weidong Tian, Kai Zhao, Lin Han, Kai Shu, Suojun Zhang, Jianghong Man, Chao You, Haohao Huang, Ran Li   +20 more
doaj   +2 more sources

Down regulating PHGDH affects the lactate production of sertoli cells in varicocele [PDF]

Reproductive Biology and Endocrinology, 2020
Background Although varicocele is considered to be one of the leading causes of male infertility, the precise mechanism underlying how varicocele leads to male infertility is not completely understood. We found the lactate concentration on the varicocele
Wen-bin Guo, Zhen-hui Huang, Cheng Yang, Xian-yuan Lv, Hui Xia, Hu Tian, Jian-kun Yang, Qi-zhao Zhou, Ming-kun Chen, Kang-yi Xue, Cun-dong Liu   +10 more
doaj   +3 more sources