Results 21 to 30 of about 8,172 (201)

Post-translational regulation of human D-3-phosphoglycerate dehydrogenase in Alzheimer's disease. [PDF]

Protein Sci
Abstract Emerging evidence suggests that sex‐specific differences in L‐serine (L‐Ser) metabolism play a key role in Alzheimer's disease (AD). While disruptions in amino acid balance are well known, recent findings point to a dimorphic regulation of the serine biosynthetic pathway.
Zerbini E, Riva D, Maffioli E, Tedeschi G, Sacchi S, Pollegioni L.   +5 more
europepmc   +2 more sources

Identification of a novel PHGDH covalent inhibitor by chemical proteomics and phenotypic profiling

Acta Pharmaceutica Sinica B, 2022
The first rate-limiting enzyme of the serine synthesis pathway (SSP), phosphoglycerate dehydrogenase (PHGDH), is hyperactive in multiple tumors, which leads to the activation of SSP and promotes tumorigenesis. However, only a few inhibitors of PHGDH have
Chen Chen, Tianyu Zhu, Xiaoqin Liu, Dongrong Zhu, Yi Zhang, Sifang Wu, Chao Han, Hao Zhang, Jianguang Luo, Lingyi Kong   +9 more
doaj   +1 more source

Phosphoglycerate dehydrogenase positively regulates the proliferation of chicken muscle cells

Poultry Science, 2022
: Phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme in the serine synthesis pathway. However, the regulatory role of PHGDH in muscle development is unclear.
Han Wang, Moran Hu, Zhaoxue Ding, Xiaolong Zhou, Songbai Yang, Zhonghao Shen, Feifei Yan, Ayong Zhao   +7 more
doaj   +1 more source

Decoding the Integrated Stress Response of Pancreatic Cancer: Identifying a Serine-dependent Tumor Subset Under Metabolic Relationships With CAFs. [PDF]

Adv Sci (Weinh)
Researchers identified a pancreatic cancer subset with low global protein synthesis but heightened translation of stress‐response genes like ATF4, rendering cells resistant to chemotherapy and apoptosis. These tumors depend on serine and cysteine from surrounding cancer‐associated fibroblasts (CAFs), which shift to produce serine by curbing collagen ...
Shin S, Liauzun M, Solorzano J, Bras ML, Jean C, Fourneaux B, Dore M, Fevrier L, Belhabib I, Brunel A, Neuzillet C, Larroque M, Joffre C, Rocchi S, Fraunhoffer N, Perraud A, Mathonnet M, Pancaldi V, Linares L, Iovanna J, Dusetti N, Larsson O, Nicolle R, Pyronnet S, Bousquet C, Martineau Y.   +25 more
europepmc   +2 more sources

Nuclear PHGDH protects cancer cells from nutrient stress

Nature Metabolism, 2021
In this study, the serine biosynthetic enzyme PHGDH is shown to transition from the cytosol to the nucleus following nutrient stress. Nuclear PHGDH reduces local NAD+ availability needed for the PARylation of the transcription factor c-Jun. Consequently, c-Jun activity is reduced, contributing to sustained cancer cell proliferation.
Annibali, Daniela, Fendt, Sarah-Maria
openaire   +3 more sources

Comprehensive analysis of PHGDH for predicting prognosis and immunotherapy response in patients with endometrial carcinoma

BMC Medical Genomics, 2023
Background PHGDH (Phosphoglycerate Dehydrogenase) is the first branch enzyme in the serine biosynthetic pathway and plays a vital role in several cancers. However, little is known about the clinical significance of PHGDH in endometrial cancer.
He Zhang, Weimin Kong, Xiaoling Zhao, Yunkai Xie, Dan Luo, Shuning Chen   +5 more
doaj   +1 more source

Phosphoglycerate dehydrogenase (PHGDH) inhibitors: a comprehensive review 2015–2020

Expert Opinion on Therapeutic Patents, 2021
Introduction:The phosphoglycerate dehydrogenase (PHGDH), a metabolic enzyme involved in the serine synthetic pathway (SSP), appears to play a central role in supporting cancer growth and proliferation. PHGDH is a dehydrogenase whose expression in cancers was first demonstrated in 2010.
Quentin Spillier, Raphaël Frédérick
openaire   +3 more sources

Identification of Novel Natural Inhibitors to Human 3-Phosphoglycerate Dehydrogenase (PHGDH) for Cancer Treatment

Molecules, 2022
Targeting the serine biosynthesis pathway enzymes has turned up as a novel strategy for anti-cancer therapeutics. 3- Phosphoglycerate dehydrogenase (PHGDH) is the rate-limiting enzyme that catalyzes the conversion of 3-Phosphoglyceric acid (3-PG) into 3 ...
Ayesha Sadiqa, Azhar Rasul, Mudassir Hassan, Salma Sultana, Farhat Jabeen   +4 more
doaj   +1 more source

PHGDH Orchestrates Cell Cycle Progression to Drive Cardiomyocyte Proliferation and Myocardial Regeneration via TGF-β/Smad Signalling Pathway. [PDF]

Cell Prolif
PHGDH promoted cardiomyocyte proliferation and myocardial regeneration via cell cycle and TGF‐β/Smad signalling pathways during cardiac repair. Moreover, PHGDH benefits cardiac repair and cardiomyocyte proliferation in mammalian mice following MI. ABSTRACT The mature mammalian heart has limited ability for self‐repair and regeneration.
Zhang H, Zhang L, Feng Z, Li X, Qiu Z, Wang X, Qian L.   +6 more
europepmc   +2 more sources

Characterization of PHGDH expression in bladder cancer: potential targeting therapy with gemcitabine/cisplatin and the contribution of promoter DNA hypomethylation

Molecular Oncology, 2020
d‐3‐Phosphoglycerate dehydrogenase (PHGDH) conducts an important step in the synthesis of serine. Importantly, the PHGDH gene is often amplified in certain cancers.
Hirofumi Yoshino, Hideki Enokida, Yoichi Osako, Nijiro Nohata, Masaya Yonemori, Satoshi Sugita, Kazuki Kuroshima, Masafumi Tsuruda, Shuichi Tatarano, Masayuki Nakagawa   +9 more
doaj   +1 more source