PHGDH supports liver ceramide synthesis and sustains lipid homeostasis [PDF]
Cancer & Metabolism, 2020 Background d-3-phosphoglycerate dehydrogenase (PHGDH), which encodes the first enzyme in serine biosynthesis, is overexpressed in human cancers and has been proposed as a drug target.
Yun Pyo Kang +8 more
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Macrophage-specific PHGDH protects against MAFLD by suppressing TAK1
Cell ReportsSummary: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a progressive disease with only one approved treatment currently available.
Penghui Hu +16 more
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Increased Expression of PHGDH and Prognostic Significance in Colorectal Cancer
Translational Oncology, 2016 Phosphoglycerate dehydrogenase (PHGDH) plays an essential role in cancer-specific metabolic reprogramming. It has been reported as a putative metabolic oncogene in several types of human malignant tumors, such as breast cancer and melanoma.
Xiao-qin Jia +6 more
doaj +3 more sources
Exercise Reprograms the Spatial Function of Phosphoglycerate Dehydrogenase of a Pathogenic Nuclear Transcription Factor (PHGDH): A Narrative Review [PDF]
MetabolitesBackground: Alzheimer’s disease (AD) represents a significant therapeutic challenge, largely attributed to the complex interplay of genetic and non-genetic mechanisms. Among the latter, metabolic dysregulation has emerged as a critical factor influencing
Dong Yang, Wen Guo, Liang Guo
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PHGDH: a novel therapeutic target in cancer
Experimental and Molecular MedicineSerine is a key contributor to the generation of one-carbon units for DNA synthesis during cellular proliferation. In addition, it plays a crucial role in the production of antioxidants that prevent abnormal proliferation and stress in cancer cells.
Chae Min Lee +5 more
doaj +3 more sources
XPR1 downregulation inhibits hepatocellular carcinoma progression by suppressing serine metabolism [PDF]
Redox BiologyXenotropic and polytropic retrovirus receptor 1 (XPR1) is highly expressed in various tumors and is associated with poor clinical prognosis, making it a proposed therapeutic target for cancer. However, the mechanism of XPR1 in tumorigenesis, particularly
Zi-qiang Liao +8 more
doaj +2 more sources
Pharmaceuticals, 2020 For many years now, targeting deregulation within cancer cells’ metabolism has appeared as a promising strategy for the development of more specific and efficient cancer treatments.
Olivier Feron +2 more
exaly +3 more sources
Down regulating PHGDH affects the lactate production of sertoli cells in varicocele [PDF]
Reproductive Biology and Endocrinology, 2020 Background Although varicocele is considered to be one of the leading causes of male infertility, the precise mechanism underlying how varicocele leads to male infertility is not completely understood. We found the lactate concentration on the varicocele
Wen-bin Guo +10 more
doaj +3 more sources
PHGDH heterogeneity potentiates cancer cell dissemination and metastasis [PDF]
Nature, 2022 Cancer metastasis requires the transient activation of cellular programs enabling dissemination and seeding in distant organs1. Genetic, transcriptional and translational heterogeneity contributes to this dynamic process2,3. Metabolic heterogeneity has also been observed4, yet its role in cancer progression is less explored.
Matteo Rossi +50 more
openaire +4 more sources
Identification of a novel PHGDH covalent inhibitor by chemical proteomics and phenotypic profiling
Acta Pharmaceutica Sinica B, 2022 The first rate-limiting enzyme of the serine synthesis pathway (SSP), phosphoglycerate dehydrogenase (PHGDH), is hyperactive in multiple tumors, which leads to the activation of SSP and promotes tumorigenesis. However, only a few inhibitors of PHGDH have
Chen Chen +9 more
doaj +1 more source