Serine metabolism orchestrates macrophage polarization by regulating the IGF1–p38 axis [PDF]
Cellular and Molecular Immunology, 2022 Qiujing Yu, Penghui Hu, Zemin Ji
exaly +2 more sources
l-Serine links metabolism with neurotransmission [PDF]
Progress in Neurobiology, 2021 Brain energy metabolism is often considered as a succession of biochemical steps that metabolize the fuel (glucose and oxygen) for the unique purpose of providing sufficient ATP to maintain the huge information processing power of the brain. However, a significant fraction (10-15 %) of glucose is shunted away from the ATP-producing pathway (oxidative ...
Maugard, Marianne +3 more
openaire +3 more sources
Serine metabolism during differentiation of human iPSC-derived astrocytes [PDF]
, 2023 : Astrocytes are essential players in development and functions, being particularly relevant as regulators of brain energy metabolism, ionic homeostasis and synaptic transmission.
Anna Maria Rinaldi +44 more
core +1 more source
Serine Metabolism Regulates YAP Activity Through USP7 in Colon Cancer
Frontiers in Cell and Developmental Biology, 2021 Metabolic reprogramming is a vital factor in the development of many types of cancer, including colon cancer. Serine metabolic reprogramming is a major feature of tumor metabolism.
Xiaoya Zhao +14 more
doaj +1 more source
Resistance to serine in Bacillus subtilis : Identification of the serine transporter YbeC and of a metabolic network that links serine and threonine metabolism [PDF]
Environmental Microbiology, 2020 Summary The Gram-positive bacterium Bacillus subtilis uses serine not only as building block for proteins but also as an important precursor in many anabolic reactions. Moreover, a lack of serine results in the initiation of biofilm formation.
Anika Klewing +7 more
openaire +3 more sources
Pharmacokinetics of oral l-serine supplementation in a single patient
Molecular Genetics and Metabolism Reports, 2020 Serine, a non-essential amino acid, has attracted clinical attention because of potential benefit in certain metabolic and neurological disorders. Despite the therapeutic potential, little is known about the pharmacokinetics of l-serine metabolism in ...
Danny E. Miller +3 more
doaj +1 more source
Serine-associated one-carbon metabolic reprogramming: a new anti-cancer therapeutic strategy
Frontiers in Oncology, 2023 Tumour metabolism is a major focus of cancer research, and metabolic reprogramming is an important feature of malignant tumours. Serine is an important non-essential amino acid, which is a main resource of one-carbon units in tumours.
Jing Zhang +6 more
doaj +1 more source
Serine metabolism in human pregnancy [PDF]
American Journal of Physiology-Endocrinology and Metabolism, 2003 Serine plays an important role in intermediary metabolism as a source of one carbon pool for nucleotide biosynthesis, as a precursor for glycine and glucose, and as a contributor to cysteine biosynthesis. A unique serine-glycine cycling between the liver and the placenta has been demonstrated in the sheep fetus. We hypothesized that, because of serine'
Satish C, Kalhan +5 more
openaire +2 more sources
Multi-omics Analysis of the Role of PHGDH in Colon Cancer
Technology in Cancer Research & Treatment, 2023 Objectives : Serine metabolism is essential for tumor cells. Endogenous serine arises from de novo synthesis pathways. As the rate-limiting enzyme of this pathway, PHGDH is highly expressed in a variety of tumors including colon cancer.
Zhihui Dai MSc +6 more
doaj +1 more source
ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction
Cell Reports, 2021 Summary: The serine synthesis pathway (SSP) involving metabolic enzymes phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1), and phosphoserine phosphatase (PSPH) drives intracellular serine biosynthesis and is indispensable ...
Xingyao Li +9 more
doaj +1 more source