Results 21 to 30 of about 256,312 (241)
Serine metabolism in human pregnancy [PDF]
American Journal of Physiology-Endocrinology and Metabolism, 2003 Serine plays an important role in intermediary metabolism as a source of one carbon pool for nucleotide biosynthesis, as a precursor for glycine and glucose, and as a contributor to cysteine biosynthesis. A unique serine-glycine cycling between the liver and the placenta has been demonstrated in the sheep fetus. We hypothesized that, because of serine'
Satish C, Kalhan +5 more
openaire +2 more sources
Multi-omics Analysis of the Role of PHGDH in Colon Cancer
Technology in Cancer Research & Treatment, 2023 Objectives : Serine metabolism is essential for tumor cells. Endogenous serine arises from de novo synthesis pathways. As the rate-limiting enzyme of this pathway, PHGDH is highly expressed in a variety of tumors including colon cancer.
Zhihui Dai MSc +6 more
doaj +1 more source
Dietary intake and glutamine-serine metabolism control pathologic vascular stiffness [PDF]
Cell MetabolismJingsi Zhao +2 more
exaly +2 more sources
Frontiers in Genetics, 2021 The use of differentiating human induced pluripotent stem cells (hiPSCs) in mini-tissue organoids provides an invaluable resource for regenerative medicine applications, particularly in the field of disease modeling.
Qizheng Wang +15 more
doaj +1 more source
The Intersection of Serine Metabolism and Cellular Dysfunction in Retinal Degeneration
Cells, 2020 In the past, the importance of serine to pathologic or physiologic anomalies was inadequately addressed. Omics research has significantly advanced in the last two decades, and metabolomic data of various tissues has finally brought serine metabolism to ...
Tirthankar Sinha +3 more
doaj +1 more source
Serine and one-carbon metabolisms bring new therapeutic venues in prostate cancer
Discover Oncology, 2021 Serine and one-carbon unit metabolisms are essential biochemical pathways implicated in fundamental cellular functions such as proliferation, biosynthesis of important anabolic precursors and in general for the availability of methyl groups.
Carlo Ganini +14 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Colorectal cancer (CRC) is one of the most common malignancies globally. Increasing evidence indicates that circular RNAs (circRNAs) play a pivotal role in various cancers. The present study focused on exploring the role of a functionally unknown circRNA,
Shengbai Sun +18 more
doaj +1 more source
Serine Supports IL-1β Production in Macrophages Through mTOR Signaling
Frontiers in Immunology, 2020 Intracellular metabolic programs tightly regulate the functions of macrophages, and previous studies have shown that serine mainly shapes the macrophage function via one-carbon metabolism.
Siyuan Chen +8 more
doaj +1 more source
Linking Serine/Glycine Metabolism to Radiotherapy Resistance [PDF]
Cancers, 2021 The activation of de novo serine/glycine biosynthesis in a subset of tumors has been described as a major contributor to tumor pathogenesis, poor outcome, and treatment resistance. Amplifications and mutations of de novo serine/glycine biosynthesis enzymes can trigger pathway activation; however, a large group of cancers displays serine/glycine pathway
Sanchez-Castillo, Anais +2 more
openaire +4 more sources
Computational and Structural Biotechnology Journal, 2021 Human serine hydroxymethyltransferase (SHMT) regulates the serine-glycine one carbon metabolism and plays a role in cancer metabolic reprogramming. Two SHMT isozymes are acting in the cell: SHMT1 encoding the cytoplasmic isozyme, and SHMT2 encoding the ...
Michele Monti +7 more
doaj +1 more source