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Targeting one‐carbon metabolism for cancer immunotherapy [PDF]
Clinical and Translational MedicineBackground One‐carbon (1C) metabolism is a metabolic network that plays essential roles in biological reactions. In 1C metabolism, a series of nutrients are used to fuel metabolic pathways, including nucleotide metabolism, amino acid metabolism, cellular
Xinxin Ren +9 more
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One-carbon metabolism in cancer [PDF]
British Journal of Cancer, 2017 Cells require one-carbon units for nucleotide synthesis, methylation and reductive metabolism, and these pathways support the high proliferative rate of cancer cells. As such, anti-folates, drugs that target one-carbon metabolism, have long been used in the treatment of cancer. Amino acids, such as serine are a major one-carbon source, and cancer cells
Oliver D K Maddocks, Maddocks Oliver D K
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One‐carbon metabolism, folate, zinc and translation [PDF]
Microbial Biotechnology, 2020 Summary The translation process, central to life, is tightly connected to the one‐carbon (1‐C) metabolism via a plethora of macromolecule modifications and specific effectors. Using manual genome annotations and putting together a variety of experimental
Antoine Danchin +2 more
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COVID-19 and One-Carbon Metabolism
International Journal of Molecular Sciences, 2022 Dysregulation of one-carbon metabolism affects a wide range of biological processes and is associated with a number of diseases, including cardiovascular disease, dementia, neural tube defects, and cancer. Accumulating evidence suggests that one-carbon metabolism plays an important role in COVID-19.
Joanna Perła-Kaján +1 more
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One-Carbon Metabolism in Health and Disease [PDF]
Cell Metabolism, 2017 One-carbon (1C) metabolism, mediated by the folate cofactor, supports multiple physiological processes. These include biosynthesis (purines and thymidine), amino acid homeostasis (glycine, serine, and methionine), epigenetic maintenance, and redox defense.
Gregory S Ducker, Joshua D Rabinowitz
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The Impact of One Carbon Metabolism on Histone Methylation [PDF]
Frontiers in Genetics, 2019 The effect of one carbon metabolism on DNA methylation has been well described, bridging nutrition, metabolism, and epigenetics. This modification is mediated by the metabolite S-adenosyl methionine (SAM), which is also the methyl-donating substrate of ...
Magdalini Serefidou +2 more
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The toxic side of one-carbon metabolism and epigenetics
Redox Biology, 2021 One-carbon metabolism is a central metabolic hub that provides one-carbon units for essential biosynthetic reactions and for writing epigenetics marks.
Agustín E. Morellato +2 more
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The Antioxidant Role of One-Carbon Metabolism on Stroke [PDF]
Antioxidants, 2020 One-carbon (1C) metabolism is a metabolic network that is centered on folate, a B vitamin; it integrates nutritional signals with biosynthesis, redox homeostasis, and epigenetics.
Kassidy Burgess +5 more
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Serine and one-carbon metabolisms bring new therapeutic venues in prostate cancer
Discover Oncology, 2021 Serine and one-carbon unit metabolisms are essential biochemical pathways implicated in fundamental cellular functions such as proliferation, biosynthesis of important anabolic precursors and in general for the availability of methyl groups.
Carlo Ganini +14 more
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Progress in One-carbon Metabolism and Tumor Therapy
Zhongliu Fangzhi Yanjiu, 2021 In recent years, it has already run into a common view that "tumor is a metabolic disease", and the reprogramming of tumor metabolism has become the focus of current research.
CHAI Dongqi, WANG Weixing
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