Results 11 to 20 of about 490,236 (289)

Mitochondrial One-Carbon Metabolism and Alzheimer’s Disease [PDF]

International Journal of Molecular Sciences
Mitochondrial one-carbon metabolism provides carbon units to several pathways, including nucleic acid synthesis, mitochondrial metabolism, amino acid metabolism, and methylation reactions. Late-onset Alzheimer’s disease is the most common age-related neurodegenerative disease, characterised by impaired energy metabolism, and is potentially linked to ...
Yizhou Yu, L. Miguel Martins
core   +7 more sources

Targeted Proteomics for Monitoring One-Carbon Metabolism in Liver Diseases

Metabolites, 2022
Liver diseases cause approximately 2 million deaths per year worldwide and had an increasing incidence during the last decade. Risk factors for liver diseases include alcohol consumption, obesity, diabetes, the intake of hepatotoxic substances like ...
Laura Guerrero, Alberto Paradela, Fernando J. Corrales   +2 more
doaj   +3 more sources

One-Carbon and Polyamine Metabolism as Cancer Therapy Targets

Biomolecules, 2022
Cancer metabolic reprogramming is essential for maintaining cancer cell survival and rapid replication. A common target of this metabolic reprogramming is one-carbon metabolism which is notable for its function in DNA synthesis, protein and DNA ...
Anowarul Islam, Zeeshan Shaukat, Rashid Hussain, Stephen L. Gregory   +3 more
doaj   +2 more sources

Subcellular one carbon metabolism in cancer, aging and epigenetics [PDF]

Frontiers in Epigenetics and Epigenomics
The crosstalk between metabolism and epigenetics is an emerging field that is gaining importance in different areas such as cancer and aging, where changes in metabolism significantly impacts the cellular epigenome, in turn dictating changes in chromatin
Tiziano Bernasocchi, Tiziano Bernasocchi, Raul Mostoslavsky, Raul Mostoslavsky   +3 more
doaj   +2 more sources

Genetic markers of One-Carbon Metabolism Disorders in Schizophrenial

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2019
The paper presents the results of the literature review and the authors’ own studies of the association of several several single-nucleotide genetic polymorphisms (SNP), which affect one-carbon metabolism, with a risk of schizophrenia and the severity of
T. V. Zhilyaeva, A. S. Piatoikina, A. S. Blagonravova, G. E. Mazo   +3 more
doaj   +3 more sources

392 Targeting One-Carbon Metabolism in Brain Cancer [PDF]

Journal of Clinical and Translational Science
OBJECTIVES/GOALS: Glioblastoma (GBM) is the most malignant brain tumor in adults and remains incurable with an average survival of 15 months after diagnosis.
Emma Rowland, Nagi G. Ayad
doaj   +2 more sources

One-carbon metabolism and risk of PCOS: insights from Mendelian randomization [PDF]

Journal of Ovarian Research
Background Abnormal one-carbon metabolism has been reported by observational studies to contribute to an increased risk of polycystic ovary syndrome (PCOS) and undesirable reproductive outcomes in women with PCOS.
Yifan Zhao, Gaochen Zhang, Jiexue Pan, Hefeng Huang   +3 more
doaj   +2 more sources

One carbon metabolism in SAR11 pelagic marine bacteria. [PDF]

PLoS ONE, 2011
The SAR11 Alphaproteobacteria are the most abundant heterotrophs in the oceans and are believed to play a major role in mineralizing marine dissolved organic carbon.
Jing Sun, Laura Steindler, J Cameron Thrash, Kimberly H Halsey, Daniel P Smith, Amy E Carter, Zachary C Landry, Stephen J Giovannoni   +7 more
doaj   +1 more source

Alterations in One-Carbon Metabolism in Celiac Disease [PDF]

Nutrients, 2020
Celiac disease (CD) is an autoimmune enteropathy associated with alterations of metabolism. Metabolomics studies, although limited, showed changes in choline, choline-derived lipids, and methionine concentrations, which could be ascribed to alterations in one-carbon metabolism. To date, no targeted metabolomics analysis investigating differences in the
Rafael Martín-Masot, Natàlia Mota-Martorell, Mariona Jové, José Maldonado, Reinald Pamplona, Teresa Nestares   +5 more
openaire   +5 more sources

Interspecific Variation in One-Carbon Metabolism within the Ovarian Follicle, Oocyte, and Preimplantation Embryo: Consequences for Epigenetic Programming of DNA Methylation

, 2021
One-carbon (1C) metabolism provides methyl groups for the synthesis and/or methylation 20 of purines and pyrimidines, biogenic amines, proteins and phospholipids.
Desmond A. R. Tutt, Emes, Rd, Wing Yee Kwong, Kwong, Wing Yee, Helen M. Byrne, Kwong, Wy, Xu, J, Barrett, David A., David A. Barrett, Sinclair, Kd, Juan Xu, Byrne, Hm, Emes, Richard D., Valerie Pestinger, Tutt, Dar, Tutt, Desmond A. R., Clare, Constance E., Pestinger, V, Clare, Ce, Constance E. Clare, Xu, Juan, Kevin D. Sinclair, Byrne, Helen M., Sinclair, Kevin D., Richard D. Emes, Pestinger, Valerie, Barrett, Da   +26 more
core   +1 more source