Results 31 to 40 of about 20,326,114 (289)

IDH3α regulates one-carbon metabolism in glioblastoma [PDF]

Science Advances, 2019
IDH3α promotes glioblastoma progression and links mitochondrial metabolism to cSHMT-controlled one-carbon metabolism.
Jasmine L. May, Fotini M. Kouri, Lisa A. Hurley, Juan Liu, Serena Tommasini-Ghelfi, Yanrong Ji, Peng Gao, Andrea E. Calvert, Andrew Lee, Navdeep S. Chandel, Ramana V. Davuluri, Craig M. Horbinski, Jason W. Locasale, Alexander H. Stegh   +13 more
openaire   +2 more sources

Abnormalities in one-carbon metabolism in young patients with psychosis

Frontiers in Psychiatry, 2023
IntroductionFolates, the main actors in one-carbon (C1) metabolism, are involved in synthesising monoamines and maintaining genomic stability. Previous studies support the association between C1 metabolism and schizophrenia.
Ariel Frajerman, Ariel Frajerman, Ariel Frajerman, Marie Urban, Fabrice Rivollier, Fabrice Rivollier, Marion Plaze, Boris Chaumette, Boris Chaumette, Boris Chaumette, Marie-Odile Krebs, Marie-Odile Krebs, Linda Scoriels, Linda Scoriels   +13 more
doaj   +1 more source

One-carbon metabolism in psychiatric illness [PDF]

Nutrition Research Reviews, 2006
The cost of psychiatric illness to the UK economy was recently estimated at £77 billion annually. Despite years of research no firm aetiological explanation exists, and with no physiological or biochemical markers diagnosis is made entirely on a behavioural basis. All current pharmacological therapies are associated with serious long-term side effects.
openaire   +2 more sources

One-Carbon Metabolism in Alzheimer’s Disease and Parkinson’s Disease Brain Tissue

, 2022
Disruptions in one-carbon metabolism and elevated homocysteine have been previously implicated in the development of dementia associated with Alzheimer’s disease (AD) and Parkinson’s disease (PD).
Karel Kalecký, Paula Ashcraft, Teodoro Bottiglieri   +2 more
core   +1 more source

Choline and one-carbon metabolite response to egg, beef and fish among healthy young men: A short-term randomized clinical study

Clinical Nutrition Experimental, 2016
Background: Homeostatic mechanisms that regulate long-term circulating concentrations of choline and one-carbon metabolites can obscure the relationship between diet and nutritional response.
Clara E. Cho, Siraphat Taesuwan, Olga V. Malysheva, Erica Bender, Jian Yan, Marie A. Caudill   +5 more
doaj   +1 more source

Chromosomal Instability Causes Sensitivity to Polyamines and One-Carbon Metabolism

Metabolites, 2023
Aneuploidy, or having a disrupted genome, is an aberration commonly found in tumours but rare in normal tissues. It gives rise to proteotoxic stress as well as a stereotypical oxidative shift, which makes these cells sensitive to internal and ...
Anowarul Islam, Zeeshan Shaukat, David L. Newman, Rashid Hussain, Michael G. Ricos, Leanne Dibbens, Stephen L. Gregory   +6 more
doaj   +1 more source

Mitochondrial dysfunction remodels one-carbon metabolism in human cells

eLife, 2016
Mitochondrial dysfunction is associated with a spectrum of human disorders, ranging from rare, inborn errors of metabolism to common, age-associated diseases such as neurodegeneration.
Xiaoyan Robert Bao, Shao-En Ong, Olga Goldberger, Jun Peng, Rohit Sharma, Dawn A Thompson, Scott B Vafai, Andrew G Cox, Eizo Marutani, Fumito Ichinose, Wolfram Goessling, Aviv Regev, Steven A Carr, Clary B Clish, Vamsi K Mootha   +14 more
doaj   +1 more source

Formaldehyde regulates S-adenosylmethionine biosynthesis and one-carbon metabolism [PDF]

, 2023
One-carbon metabolism is an essential branch of cellular metabolism that intersects with epigenetic regulation. In this work, we show how formaldehyde (FA), a one-carbon unit derived from both endogenous sources and environmental exposure, regulates one ...
Millington, Christopher L, Bruemmer, Kevin J, Pontel, Lucas B, Ge, Eva J, Toh, Joel DW, Esteller, Manel, Ingolia, Nicholas T, Dingler, Felix A, Pulos-Holmes, Mia C, Nomura, Daniel K, Ward, Carl C, Garcia-Prieto, Carlos A, Patel, Ketan J, Pham, Vanha N, Chang, Christopher J, Tenney, Logan   +15 more
core   +1 more source

Glioma cells require one-carbon metabolism to survive glutamine starvation

Acta Neuropathologica Communications, 2021
Cancer cells optimize nutrient utilization to supply energetic and biosynthetic pathways. This metabolic process also includes redox maintenance and epigenetic regulation through nucleic acid and protein methylation, which enhance tumorigenicity and ...
Kazuhiro Tanaka, Takashi Sasayama, Hiroaki Nagashima, Yasuhiro Irino, Masatomo Takahashi, Yoshihiro Izumi, Takiko Uno, Naoko Satoh, Akane Kitta, Katsusuke Kyotani, Yuichi Fujita, Mitsuru Hashiguchi, Tomoaki Nakai, Masaaki Kohta, Yoichi Uozumi, Masakazu Shinohara, Kohkichi Hosoda, Takeshi Bamba, Eiji Kohmura   +18 more
doaj   +1 more source

Simplifying the B Complex: How Vitamins B6 and B9 Modulate One Carbon Metabolism in Cancer and Beyond [PDF]

, 2022
Vitamin B micronutrients are essential regulators of one carbon metabolism that ensures human health. Vitamin B9, or folate, lies at the heart of the folate cycle and converges with the methionine cycle to complete the one carbon pathway.
Nguyen, Steven T, Leonard, Jack T., Seabrook, Laurence J, Leonard, Jack T, Lauren V. Albrecht, Carolina N. Franco, Albrecht, Lauren V, Steven T. Nguyen, Jack T. Leonard, Franco, Carolina N., Albrecht, Lauren V., Seabrook, Laurence J., Nguyen, Steven T., Laurence J. Seabrook, Franco, Carolina N   +14 more
core   +1 more source