Results 31 to 40 of about 490,236 (289)

One-Carbon Metabolism in Alzheimer’s Disease and Parkinson’s Disease Brain Tissue

, 2022
Disruptions in one-carbon metabolism and elevated homocysteine have been previously implicated in the development of dementia associated with Alzheimer’s disease (AD) and Parkinson’s disease (PD).
Karel Kalecký, Paula Ashcraft, Teodoro Bottiglieri   +2 more
core   +1 more source

Metabolic responses of primary and transformed cells to intracellular Listeria monocytogenes. [PDF]

, 2012
The metabolic response of host cells, in particular of primary mammalian cells, to bacterial infections is poorly understood. Here, we compare the carbon metabolism of primary mouse macrophages and of established J774A.1 cells upon Listeria monocytogenes
Wolfgang Eisenreich (108576), Anette Schulz (108573), Andreas Götz (108569), Gillmaier, Nadine, Götz, Andreas, Nadine Gillmaier, Schulz, Anette, Werner Goebel, Goebel, Werner, Eisenreich, Wolfgang, Werner Goebel (7241), Andreas Götz, Anette Schulz, Wolfgang Eisenreich, Nadine Gillmaier (108566)   +14 more
core   +1 more source

Interactions between Radiation and One-Carbon Metabolism

, 2022
Metabolic reprogramming is a hallmark of cancer. Cancer cells rewire one-carbon metabolism, a central metabolic pathway, to turn nutritional inputs into essential biomolecules required for cancer cell growth and maintenance.
Daniel R. Wahl, Navyateja Korimerla
core   +1 more source

One-Carbon Metabolism: Pulling the Strings behind Aging and Neurodegeneration

Cells, 2022
One-carbon metabolism (OCM) is a network of biochemical reactions delivering one-carbon units to various biosynthetic pathways. The folate cycle and methionine cycle are the two key modules of this network that regulate purine and thymidine synthesis ...
Eirini Lionaki, Christina Ploumi, Nektarios Tavernarakis   +2 more
doaj   +1 more source

Human mitochondrial MTHFD2 is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase

Cancer & Metabolism, 2017
Background Folate-dependent one-carbon metabolism provides one-carbon units for several biological processes. This pathway is highly compartmentalized in eukaryotes, with the mitochondrial pathway producing formate for use in cytoplasmic processes.
Minhye Shin, Jessica Momb, Dean R. Appling   +2 more
doaj   +1 more source

Abnormalities in one-carbon metabolism in young patients with psychosis

Frontiers in Psychiatry, 2023
IntroductionFolates, the main actors in one-carbon (C1) metabolism, are involved in synthesising monoamines and maintaining genomic stability. Previous studies support the association between C1 metabolism and schizophrenia.
Ariel Frajerman, Ariel Frajerman, Ariel Frajerman, Marie Urban, Fabrice Rivollier, Fabrice Rivollier, Marion Plaze, Boris Chaumette, Boris Chaumette, Boris Chaumette, Marie-Odile Krebs, Marie-Odile Krebs, Linda Scoriels, Linda Scoriels   +13 more
doaj   +1 more source

One-carbon metabolism in psychiatric illness [PDF]

Nutrition Research Reviews, 2006
The cost of psychiatric illness to the UK economy was recently estimated at £77 billion annually. Despite years of research no firm aetiological explanation exists, and with no physiological or biochemical markers diagnosis is made entirely on a behavioural basis. All current pharmacological therapies are associated with serious long-term side effects.
openaire   +2 more sources

Choline and one-carbon metabolite response to egg, beef and fish among healthy young men: A short-term randomized clinical study

Clinical Nutrition Experimental, 2016
Background: Homeostatic mechanisms that regulate long-term circulating concentrations of choline and one-carbon metabolites can obscure the relationship between diet and nutritional response.
Clara E. Cho, Siraphat Taesuwan, Olga V. Malysheva, Erica Bender, Jian Yan, Marie A. Caudill   +5 more
doaj   +1 more source

Chromosomal Instability Causes Sensitivity to Polyamines and One-Carbon Metabolism

Metabolites, 2023
Aneuploidy, or having a disrupted genome, is an aberration commonly found in tumours but rare in normal tissues. It gives rise to proteotoxic stress as well as a stereotypical oxidative shift, which makes these cells sensitive to internal and ...
Anowarul Islam, Zeeshan Shaukat, David L. Newman, Rashid Hussain, Michael G. Ricos, Leanne Dibbens, Stephen L. Gregory   +6 more
doaj   +1 more source

Mitochondrial dysfunction remodels one-carbon metabolism in human cells

eLife, 2016
Mitochondrial dysfunction is associated with a spectrum of human disorders, ranging from rare, inborn errors of metabolism to common, age-associated diseases such as neurodegeneration.
Xiaoyan Robert Bao, Shao-En Ong, Olga Goldberger, Jun Peng, Rohit Sharma, Dawn A Thompson, Scott B Vafai, Andrew G Cox, Eizo Marutani, Fumito Ichinose, Wolfram Goessling, Aviv Regev, Steven A Carr, Clary B Clish, Vamsi K Mootha   +14 more
doaj   +1 more source