Results 41 to 50 of about 490,236 (289)

Serine biosynthesis with one carbon catabolism represents a novel pathway for ATP generation in cells using alternative glycolysis with zero net ATP production

, 2011
Recent experimental evidence indicates that some cancer cells have an alternative glycolysis pathway with net zero ATP production, implying that upregulation of glycolysis in these cells may not be related to the generation of ATP.
Elke K. Markert, Alexei Vazquez, Elke Markert, Zoltan Oltvai, Zoltan N. Oltvai   +4 more
core   +3 more sources

Glioma cells require one-carbon metabolism to survive glutamine starvation

Acta Neuropathologica Communications, 2021
Cancer cells optimize nutrient utilization to supply energetic and biosynthetic pathways. This metabolic process also includes redox maintenance and epigenetic regulation through nucleic acid and protein methylation, which enhance tumorigenicity and ...
Kazuhiro Tanaka, Takashi Sasayama, Hiroaki Nagashima, Yasuhiro Irino, Masatomo Takahashi, Yoshihiro Izumi, Takiko Uno, Naoko Satoh, Akane Kitta, Katsusuke Kyotani, Yuichi Fujita, Mitsuru Hashiguchi, Tomoaki Nakai, Masaaki Kohta, Yoichi Uozumi, Masakazu Shinohara, Kohkichi Hosoda, Takeshi Bamba, Eiji Kohmura   +18 more
doaj   +1 more source

Simplifying the B Complex: How Vitamins B6 and B9 Modulate One Carbon Metabolism in Cancer and Beyond [PDF]

, 2022
Vitamin B micronutrients are essential regulators of one carbon metabolism that ensures human health. Vitamin B9, or folate, lies at the heart of the folate cycle and converges with the methionine cycle to complete the one carbon pathway.
Nguyen, Steven T, Leonard, Jack T., Seabrook, Laurence J, Leonard, Jack T, Lauren V. Albrecht, Carolina N. Franco, Albrecht, Lauren V, Steven T. Nguyen, Jack T. Leonard, Franco, Carolina N., Albrecht, Lauren V., Seabrook, Laurence J., Nguyen, Steven T., Laurence J. Seabrook, Franco, Carolina N   +14 more
core   +1 more source

Chromium induced neurotoxicity by altering metabolism in zebrafish larvae

Ecotoxicology and Environmental Safety, 2021
Background: Recently, both trivalent chromium Cr (III) and hexavalent chromium Cr (VI) have been reported to produce neurotoxicity. However, the underlying mechanisms of the neurotoxicity caused by different chemical valence of chromium remain unclear ...
Yawen Xu, Li Wang, Jun Zhu, Ping Jiang, Zhan Zhang, Lei Li, Qian Wu   +6 more
doaj   +1 more source

O-GlcNAc signaling increases neuron regeneration through one-carbon metabolism in Caenorhabditis elegans

eLife
Cellular metabolism plays an essential role in the regrowth and regeneration of a neuron following physical injury. Yet, our knowledge of the specific metabolic pathways that are beneficial to neuron regeneration remains sparse. Previously, we have shown
Dilip Kumar Yadav, Andrew C Chang, Noa WF Grooms, Samuel H Chung, Christopher V Gabel   +4 more
doaj   +1 more source

S-Adenosylmethionine (SAM) and S-Adenosylhomocysteine (SAH) Monitoring Using Analytical Methods in Clinical Laboratory Practice: Where Are We?

Biomedicines
S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) are essential intermediates in one-carbon metabolism and key regulators of cellular methylation capacity. Their concentrations and the SAM/SAH ratio are increasingly studied as biomarkers across
Antonina Kuty, Arkadiusz Kocur, Bartosz Molasy, Małgorzata Wrzosek   +3 more
doaj   +1 more source

FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans

Nature Communications, 2023
Flavin containing monooxygenase 2 (FMO-2) is known to increase lifespan under dietary restriction through incompletely understood mechanisms. Here the authors report that FMO-2 modifies tryptophan and methionine metabolic pathways to enhance stress ...
Hyo Sub Choi, Ajay Bhat, Marshall B. Howington, Megan L. Schaller, Rebecca L. Cox, Shijiao Huang, Safa Beydoun, Hillary A. Miller, Angela M. Tuckowski, Joy Mecano, Elizabeth S. Dean, Lindy Jensen, Daniel A. Beard, Charles R. Evans, Scott F. Leiser   +14 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

One-carbon metabolism and ionizing radiation: a multifaceted interaction

Biomolecular Concepts, 2017
Ionizing radiation (IR) is a ubiquitous component of our environment and an important tool in research and medical treatment. At the same time, IR is a potent genotoxic and epigenotoxic stressor, exposure to which may lead to negative health outcomes ...
Miousse Isabelle R., Tobacyk Julia, Melnyk Stepan, James S. Jill, Cheema Amrita K., Boerma Marjan, Hauer-Jensen Martin, Koturbash Igor   +7 more
doaj   +1 more source

Co-inhibition of glutaminolysis and one-carbon metabolism promotes ROS accumulation leading to enhancement of chemotherapeutic efficacy in anaplastic thyroid cancer

Cell Death and Disease, 2023
Anaplastic thyroid cancer (ATC) is one of the most aggressive tumors with an extremely poor prognosis. Based on the several biological features related to glutamine metabolism in ATC, we hypothesized glutaminolysis inhibition induces cell death in ATC ...
Yeseong Hwang, Hyeok Jun Yun, Jae Woong Jeong, Minki Kim, Seyeon Joo, Hae-Kyung Lee, Hang-Seok Chang, Seok-Mo Kim, Sungsoon Fang   +8 more
doaj   +1 more source