Results 61 to 70 of about 490,236 (289)

The influence of exogenous organic carbon assimilation and photoperiod on the carbon and lipid metabolism of Chlamydomonas reinhardtii [PDF]

, 2018
Microalgae are a promising platform for the production of renewable fuels and oleochemicals. Despite significant research efforts to understand the mechanisms of algal lipid accumulation, the influence of commercially relevant growth conditions on the ...
Gilmour, D.J., Gilmour, D. J., Smith, R.T., D. James Gilmour, Richard T. Smith, Smith, R. T.   +5 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

MASLD: insights on the role of folate in hepatic lipid metabolism

Frontiers in Nutrition
Metabolic dysfunction-associated steatotic liver disease (MASLD) is also known as fatty liver disease associated with non-alcoholic fatty liver disease (NAFLD), which is a spectrum of chronic liver diseases characterized by steatosis, inflammation ...
Minlan Yang, Xiaoyu Xiao, Jie Mei, Pubu-ciren, Quan Gong   +4 more
doaj   +1 more source

Creatine supplementation decreased homocysteine plasma levels in rats but not humans: A critical review with meta-analysis

Journal of Nutrition & Intermediary Metabolism, 2016
Background: Increasing evidence has shown that an elevated a level of homocysteine (Hcy) in the blood is related to several diseases. Over the last few years, studies have demonstrated creatine (Cr) synthesis and Hcy formation are metabolically connected;
Rafael Deminice, Flávia Troncon Rosa
doaj   +1 more source

IDH3α regulates one-carbon metabolism in glioblastoma [PDF]

Science Advances, 2019
IDH3α promotes glioblastoma progression and links mitochondrial metabolism to cSHMT-controlled one-carbon metabolism.
Jasmine L. May, Fotini M. Kouri, Lisa A. Hurley, Juan Liu, Serena Tommasini-Ghelfi, Yanrong Ji, Peng Gao, Andrea E. Calvert, Andrew Lee, Navdeep S. Chandel, Ramana V. Davuluri, Craig M. Horbinski, Jason W. Locasale, Alexander H. Stegh   +13 more
openaire   +2 more sources

One-carbon metabolism metabolite levels at T0 and T1 (n = 67).

, 2019
One-carbon metabolism metabolite levels at T0 and T1 (n = 67).
Bertrand D. van Zelst (7392497), Robert de Jonge (4926013), Marry M. van den Heuvel-Eibrink (7391279), Sandra G. Heil (4044344), Wim J. E. Tissing (7392494), Natanja Oosterom (5492705), Marta Fiocco (387043), Desiree E. C. Smith (7392491), Rob Pieters (294079)   +8 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

More Than a Metabolic Enzyme: MTHFD2 as a Novel Target for Anticancer Therapy?

Frontiers in Oncology, 2020
The bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2) is a mitochondrial one-carbon folate metabolic enzyme whose role in cancer was not known until recently. MTHFD2 is highly expressed in embryos and a wide range of tumors but
Zhiyuan Zhu, Gilberto Ka Kit Leung
doaj   +1 more source

Targeting serine-glycine-one-carbon metabolism as a vulnerability in cancers

Biomarker Research, 2023
The serine-glycine-one-carbon (SGOC) metabolic pathway is critical for DNA methylation, histone methylation, and redox homeostasis, in addition to protein, lipid, and nucleotide biosynthesis.
Wei Sun, Ruochen Liu, Xinyue Gao, Zini Lin, Hongao Tang, Hongjuan Cui, Erhu Zhao   +6 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source