Results 71 to 80 of about 490,236 (289)
Metabolic Potential of Cancer Cells in Context of the Metastatic Cascade
Cells, 2020 The metastatic cascade is a highly plastic and dynamic process dominated by cellular heterogeneity and varying metabolic requirements. During this cascade, the three major metabolic pillars, namely biosynthesis, RedOx balance, and bioenergetics, have ...
Mohaned Benzarti +4 more
doaj +1 more source
Virus-mediated hijack of one-carbon metabolism [PDF]
Nature Reviews Cancer, 2019 Wang et al. investigated the early metabolic changes associated with Epstein–Barr virus (EBV) infection of B cells, which may have implications for EBV-driven lymphomas.
openaire +2 more sources
Sex differences in hepatic one-carbon metabolism [PDF]
BMC Systems Biology, 2018 There are large differences between men and women of child-bearing age in the expression level of 5 key enzymes in one-carbon metabolism almost certainly caused by the sex hormones. These male-female differences in one-carbon metabolism are greatly accentuated during pregnancy.
Farrah Sadre-Marandi +3 more
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Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Formate Reduces Ischemic Injury in Female Hearts Lacking Alcohol Dehydrogenase 5
FASEB BioAdvancesIschemic heart disease is a primary cause of death for men and women in the United States. Recent epidemiologic findings, however, suggest that premenopausal women have inherent protection from many cardiovascular pathologies compared to age‐matched men,
Haley Garbus‐Grant +3 more
doaj +1 more source
Cancer Medicine, 2018 Folate‐mediated one‐carbon metabolism (FOCM) is a key pathway essential for nucleotide synthesis, DNA methylation, and repair. This pathway is a critical target for 5‐fluorouracil (5‐FU), which is predominantly used for colorectal cancer (CRC) treatment.
Jennifer Ose +19 more
doaj +1 more source
FEBS Open Bio, EarlyView.Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source
Serine and one-carbon metabolism sustain non-melanoma skin cancer progression
Cell Death Discovery, 2023 Non-melanoma skin cancer (NMSC) is a tumor that arises from human keratinocytes, showing abnormal control of cell proliferation and aberrant stratification.
Angela Cappello +7 more
doaj +1 more source
Metabolomics analysis reveals dysregulation in one carbon metabolism in Friedreich Ataxia
, 2022 Friedreich Ataxia (FA) is a rare and often fatal autosomal recessive disease in which a mitochondrial protein, frataxin (FXN), is severely reduced in all tissues. With loss of FXN, mitochondrial metabolism is severely disrupted.
Payne, R. Mark +2 more
core +1 more source