Results 11 to 20 of about 1,285,254 (263)
Serine metabolism in tumor progression and immunotherapy [PDF]
Discover OncologySerine plays a vital role in various metabolic processes including the synthesis of proteins and other amino acids, which are essential for the cell proliferation and growth.
Dong Huang, Hui Cai, HaiYu Huang
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Differential expression of enzymes associated with serine/glycine metabolism in different breast cancer subtypes. [PDF]
PLoS ONE, 2014 PURPOSE: Glycine and serine are well-known, classic metabolites of glycolysis. Here, we profiled the expression of enzymes associated with serine/glycine metabolism in different molecular subtypes of breast cancer and discuss their potential clinical ...
Sang Kyum Kim +2 more
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Cancer metabolism: Addicted to serine. [PDF]
Nature chemical biology, 2016 Phosphoglycerate dehydrogenase (PHGDH) is an enzyme of serine biosynthesis overexpressed in various types of cancer. A new series of PHGDH inhibitors selectively block proliferation of PHGDH-dependent cancer cells and reveal an unexpected role of serine biosynthesis in coordinating one-carbon metabolism.
Christian Frezza
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The Intersection of Serine Metabolism and Cellular Dysfunction in Retinal Degeneration
Cells, 2020 In the past, the importance of serine to pathologic or physiologic anomalies was inadequately addressed. Omics research has significantly advanced in the last two decades, and metabolomic data of various tissues has finally brought serine metabolism to ...
Tirthankar Sinha +3 more
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Metabolism of the neuromodulator d-serine
Cellular and Molecular Life Sciences, 2010 Over the past years, accumulating evidence has indicated that D-serine is the endogenous ligand for the glycine-modulatory binding site on the NR1 subunit of N-methyl-D-aspartate receptors in various brain areas. D-Serine is synthesized in glial cells and neurons by the pyridoxal-5' phosphate-dependent enzyme serine racemase, and it is released upon ...
POLLEGIONI, LOREDANO, SACCHI, SILVIA
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The phosphorylated pathway of serine biosynthesis affects sperm, embryo, and sporophyte development, and metabolism in Marchantia polymorpha [PDF]
Communications BiologySerine metabolism is involved in various biological processes. Here we investigate primary functions of the phosphorylated pathway of serine biosynthesis in a non-vascular plant Marchantia polymorpha by analyzing knockout mutants of MpPGDH encoding 3 ...
Mengyao Wang +17 more
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Serine metabolism in aging and age-related diseases [PDF]
GeroScienceNon-essential amino acids are often overlooked in biomedical research; however, they are crucial components of organismal metabolism. One such metabolite that is integral to physiological function is serine. Serine acts as a pivotal link connecting glycolysis with one-carbon and lipid metabolism, as well as with pyruvate and glutathione syntheses ...
Jessica M Hoffman, Shengshuai Shan
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Classical swine fever virus inhibits serine metabolism-mediated antiviral immunity by deacetylating modified PHGDH [PDF]
mBioClassical swine fever virus (CSFV), an obligate intracellular pathogen, hijacks cellular metabolism to evade immune surveillance and facilitate its replication. The precise mechanisms by which CSFV modulates immune metabolism remain largely unknown.
Xiaowen Li +20 more
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Lactylation‐Driven IGF2BP3‐Mediated Serine Metabolism Reprogramming and RNA m6A—Modification Promotes Lenvatinib Resistance in HCC [PDF]
Advanced ScienceAcquired resistance remains a bottleneck for molecular‐targeted therapy in advanced hepatocellular carcinoma (HCC). Metabolic adaptation and epigenetic remodeling are recognized as hallmarks of cancer that may contribute to acquired resistance.
Yuanxiang Lu +10 more
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MetabolitesBackground: ALDH1L1 plays a crucial role in folate metabolism, regulating the flow of one-carbon groups through the conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO2 in a NADP+-dependent reaction.
Grace Fu +4 more
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