Serine metabolism in tumor progression and immunotherapy [PDF]
Discover OncologySerine plays a vital role in various metabolic processes including the synthesis of proteins and other amino acids, which are essential for the cell proliferation and growth.
Dong Huang, Hui Cai, HaiYu Huang
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Lactylation‐Driven IGF2BP3‐Mediated Serine Metabolism Reprogramming and RNA m6A—Modification Promotes Lenvatinib Resistance in HCC [PDF]
Advanced ScienceAcquired resistance remains a bottleneck for molecular‐targeted therapy in advanced hepatocellular carcinoma (HCC). Metabolic adaptation and epigenetic remodeling are recognized as hallmarks of cancer that may contribute to acquired resistance.
Yuanxiang Lu +10 more
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Classical swine fever virus inhibits serine metabolism-mediated antiviral immunity by deacetylating modified PHGDH [PDF]
mBioClassical swine fever virus (CSFV), an obligate intracellular pathogen, hijacks cellular metabolism to evade immune surveillance and facilitate its replication. The precise mechanisms by which CSFV modulates immune metabolism remain largely unknown.
Xiaowen Li +20 more
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Differential expression of enzymes associated with serine/glycine metabolism in different breast cancer subtypes. [PDF]
PLoS ONE, 2014 PURPOSE: Glycine and serine are well-known, classic metabolites of glycolysis. Here, we profiled the expression of enzymes associated with serine/glycine metabolism in different molecular subtypes of breast cancer and discuss their potential clinical ...
Sang Kyum Kim +2 more
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Serine metabolism orchestrates macrophage polarization by regulating the IGF1–p38 axis [PDF]
Cellular and Molecular Immunology, 2022 Xiao Shan, Penghui Hu, Zemin Ji
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l-Serine links metabolism with neurotransmission [PDF]
Progress in Neurobiology, 2021 Brain energy metabolism is often considered as a succession of biochemical steps that metabolize the fuel (glucose and oxygen) for the unique purpose of providing sufficient ATP to maintain the huge information processing power of the brain. However, a significant fraction (10-15 %) of glucose is shunted away from the ATP-producing pathway (oxidative ...
Maugard, Marianne +3 more
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Resistance to serine in Bacillus subtilis : Identification of the serine transporter YbeC and of a metabolic network that links serine and threonine metabolism [PDF]
Environmental Microbiology, 2020 Summary The Gram-positive bacterium Bacillus subtilis uses serine not only as building block for proteins but also as an important precursor in many anabolic reactions. Moreover, a lack of serine results in the initiation of biofilm formation.
Anika Klewing +7 more
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Pharmacokinetics of oral l-serine supplementation in a single patient
Molecular Genetics and Metabolism Reports, 2020 Serine, a non-essential amino acid, has attracted clinical attention because of potential benefit in certain metabolic and neurological disorders. Despite the therapeutic potential, little is known about the pharmacokinetics of l-serine metabolism in ...
Danny E. Miller +3 more
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Serine-associated one-carbon metabolic reprogramming: a new anti-cancer therapeutic strategy
Frontiers in Oncology, 2023 Tumour metabolism is a major focus of cancer research, and metabolic reprogramming is an important feature of malignant tumours. Serine is an important non-essential amino acid, which is a main resource of one-carbon units in tumours.
Jing Zhang +6 more
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ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction
Cell Reports, 2021 Summary: The serine synthesis pathway (SSP) involving metabolic enzymes phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1), and phosphoserine phosphatase (PSPH) drives intracellular serine biosynthesis and is indispensable ...
Xingyao Li +9 more
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