Results 41 to 50 of about 130,012 (264)

D-3-Phosphoglycerate Dehydrogenase

Frontiers in Molecular Biosciences, 2018
l-Serine is the immediate precursor of d-serine, a major agonist of the N-methyl-d-aspartate (NMDA) receptor. l-Serine is a pivotal amino acid since it serves as a precursor to a large number of essential metabolites besides d-serine.
Gregory A. Grant, Gregory A. Grant
doaj   +1 more source

Identification and Biochemical Characterization of the Serine Biosynthetic Enzyme 3-Phosphoglycerate Dehydrogenase in Marchantia polymorpha

Frontiers in Plant Science, 2018
L-serine is an important molecule in all living organisms, and thus its biosynthesis is considered to be regulated according to demand. 3-Phosphoglycerate dehydrogenase (PGDH), the first committed enzyme of the phosphorylated pathway of L-serine ...
Hiromichi Akashi, Hiromichi Akashi, Eiji Okamura, Ryuichi Nishihama, Takayuki Kohchi, Masami Y. Hirai, Masami Y. Hirai   +6 more
doaj   +1 more source

L-serine supplementation lowers diabetes incidence and improves blood glucose homeostasis in NOD mice. [PDF]

PLoS ONE, 2018
Sphingolipids are a diverse group of lipids with important roles in beta-cell biology regulating insulin folding and controlling apoptosis. Sphingolipid biosynthesis begins with the condensation of L-serine and palmitoyl-CoA. Here we tested the effect of
Laurits J Holm, Martin Haupt-Jorgensen, Jesper Larsen, Jano D Giacobini, Mesut Bilgin, Karsten Buschard   +5 more
doaj   +1 more source

Rational Metabolic Engineering Combined with Biosensor-Mediated Adaptive Laboratory Evolution for l-Cysteine Overproduction from Glycerol in Escherichia coli

Fermentation, 2022
l-Cysteine is an important sulfur-containing amino acid with numerous applications in the pharmaceutical and cosmetic industries. The microbial production of l-cysteine has received substantial attention, and the supply of the precursor l-serine is ...
Xiaomei Zhang, Zhenhang Sun, Jinyu Bian, Yujie Gao, Dong Zhang, Guoqiang Xu, Xiaojuan Zhang, Hui Li, Jinsong Shi, Zhenghong Xu   +9 more
doaj   +1 more source

Serine racemase is involved in d-aspartate biosynthesis [PDF]

Journal of Biochemistry, 2016
d-Aspartate is found in the nervous and reproductive system and participates in various physiological roles. While several lines of evidence suggest that this amino acid has an endogenous origin, the enzyme responsible for mammalian d-Asp biosynthesis has not yet been identified.
Tomokazu, Ito, Mika, Hayashida, Saki, Kobayashi, Natsumi, Muto, Ayumi, Hayashi, Tohru, Yoshimura, Hisashi, Mori   +6 more
openaire   +2 more sources

Neu-Laxova Syndrome Is a Heterogeneous Metabolic Disorder Caused by Defects in Enzymes of the L-Serine Biosynthesis Pathway

, 2014
Neu-Laxova syndrome (NLS) is a rare autosomal-recessive disorder characterized by a recognizable pattern of severe malformations leading to prenatal or early postnatal lethality.
ELÇİOĞLU, HURİYE NURSEL
core   +2 more sources

The intervention effect of Amygdalus mongolica oil on the metabolomics and intestinal flora in pulmonary fibrosis

Frontiers in Pharmacology, 2022
Amygdalus mongolica oil is rich in unsaturated fatty acids such as inoleic acid (47.11%) and oleic acid (23.81%). Our research demonstrates that it exerts a protective effect on rat models of pulmonary fibrosis, however, little is known regarding the ...
Qian Li, Qian Li, Hong-Bing Zhou, Hong-Bing Zhou, Jia-Qi Liu, Wan-Fu Bai, Jia Wang, Zhan-Jun Yang, Min Qiu, Min Qiu, Hong Chang, Song-Li Shi, Song-Li Shi   +12 more
doaj   +1 more source

The Selectivity for Cysteine over Serine in Coenzyme A Biosynthesis [PDF]

ChemBioChem, 2005
AbstractIn the Table of Contents, the ribose moeity of coenzyme A is shown with its stereochemical centre mistakenly inverted. The correct structure appears here.magnified image
Erick, Strauss, Tadhg P, Begley
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source