Results 61 to 70 of about 451,320 (176)

NSUN2 promotes colorectal cancer progression by stabilizing PHGDH mRNA to promote serine metabolism reprogramming

Cancer & Metabolism
Purpose Cancer cells rely on serine biosynthesis for growth, but its regulation in colorectal cancer (CRC) remains not well understood. This study identifies the m5C methyltransferase NSUN2 (NOP2/Sun domain family, member 2) as a key regulator of serine ...
Hao Li, Tingyue Gong, Yongheng Zhao, Yang Luo, Shuibin Tang, Tingfeng Wang, Haiping Lin, Ming Zhong   +7 more
doaj   +1 more source

Seprase: An overview of an important matrix serine protease [PDF]

, 2008
Seprase or Fibroblast Activation Protein (FAP) is an integral membrane serine peptidase, which has been shown to have gelatinase activity. Seprase has a dual function in tumour progression.
O\u27Brien, Pamela, O'Brien, Pamela, O'Connor, Brendan, O\u27Connor, Brendan   +3 more
core   +2 more sources

The Intersection of Serine Metabolism and Cellular Dysfunction in Retinal Degeneration

Cells, 2020
In the past, the importance of serine to pathologic or physiologic anomalies was inadequately addressed. Omics research has significantly advanced in the last two decades, and metabolomic data of various tissues has finally brought serine metabolism to ...
Tirthankar Sinha, Larissa Ikelle, Muna I. Naash, Muayyad R. Al-Ubaidi   +3 more
doaj   +1 more source

Coordinate regulation of phospholipid biosynthesis by serine in Saccharomyces cerevisiae [PDF]

Journal of Bacteriology, 1987
The addition of L-serine to inositol-containing growth medium repressed membrane-associated CDPdiacylglycerol synthase (CTP:phosphatidate cytidylyltransferase, EC 2.7.7.41) and phosphatidylserine synthase (CDPdiacylglycerol:L-serine O-phosphatidyltransferase, EC 2.7.8.8) activities and subunit levels in wild-type Saccharomyces cerevisiae.
M J, Homann, A M, Bailis, S A, Henry, G M, Carman   +3 more
openaire   +2 more sources

Functional analysis of the Lactococcus lactis galU and galE genes and their impact on sugar nucleotide and exopolysaccharide biosynthesis [PDF]

, 2001
We studied the UDP-glucose pyrophosphorylase (galU) and UDP-galactose epimerase (galE) genes of Lactococcus lactis MG1363 to investigate their involvement in biosynthesis of UDP-glucose and UDP-galactose, which are precursors of glucose- and galactose ...
Boels, I.C., Vos, W.M., de, Kleerebezem, M., Ramos, A., de Vos, W.M.   +4 more
core   +1 more source

The Malate Aspartate Shuttle is important for de novo serine biosynthesis. Broeks et al.

, 2023
We hypothesized that all MAS defects lead to a secondary serine biosynthesis defect. To study whether MAS defects lead to diminished serine and glycine biosynthesis, we performed isotopic tracing experiments in 33 HEK293 cell lines with a genetic ...
Broeks, M (via Mendeley Data)
core   +1 more source

The Pivotal Role of One-Carbon Metabolism in Neoplastic Progression During the Aging Process

Biomolecules
One-carbon (1C) metabolism is a complex network of metabolic reactions closely related to producing 1C units (as methyl groups) and utilizing them for different anabolic processes, including nucleotide synthesis, methylation, protein synthesis, and ...
Avisek Majumder, Shabana Bano, Kasturi Bala Nayak   +2 more
doaj   +1 more source

Molecular and biochemical characterization of key enzymes in the cysteine and serine metabolic pathways of Acanthamoeba castellanii

Parasites & Vectors, 2018
Background Acanthamoeba spp. can cause serious human infections, including Acanthamoeba keratitis, granulomatous amoebic encephalitis and cutaneous acanthamoebiasis.
Duo Wu, Meng Feng, Zhi-xin Wang, Ke Qiao, Hiroshi Tachibana, Xun-jia Cheng   +5 more
doaj   +1 more source

Vitamin B6 is essential for serine de novo biosynthesis [PDF]

, 2017
Pyridoxal 5'-phosphate (PLP), the metabolically active form of vitamin B6, plays an essential role in brain metabolism as a cofactor in numerous enzyme reactions.
Judith J. Jans, Pras-Raves, Mia L., Mia L. Pras-Raves, Hubertus Prinsen, Ramos, Rúben J., Verhoeven-Duif, Nanda M., Willemsen, Marcel, van der Ham, Maria, Maria van der Ham, Marcel Willemsen, Burgering, Boudewijn, Nanda M. Verhoeven-Duif, Gerrits, Johan, Rúben J. Ramos, Johan Gerrits, Boudewijn Burgering, Jans, Judith J., Prinsen, Hubertus   +17 more
core   +1 more source

D-Serine inhibits serine palmitoyltransferase, the enzyme catalyzing the initial step of sphingolipid biosynthesis [PDF]

, 2000
Serine palmitoyltransferase (SPT), responsible for the initial step of sphingolipid biosynthesis, catalyzes condensation of palmitoyl coenzyme A and L-serine to produce 3-ketodihydrosphingosine (KDS).
Tomoko Hara, Nishijima, Masahiro, Masahiro Nishijima, Kentaro Hanada, Hanada, Kentaro, Hara, Tomoko   +5 more
core   +1 more source