Results 51 to 60 of about 130,012 (264)

S9 protease WprP2 catalyzes uniform cleavage on the precursor peptide in RiPP biosynthesis

Communications Chemistry
Serine proteases in ribosomally synthesized and post-translationally modified peptides (RiPPs) catalyze the cleavage on the precursor peptides in the biosynthesis of RiPP natural products. Here, we identified an uncharacterized serine protease WprP2 from
Jabal Rahmat Haedar, Abujunaid Habib Khan, Suze Ma, Stefano Donadio, Chin-Soon Phan   +4 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells

Nature Communications, 2019
The ribosomal protein RPL10 is frequently mutated in T-cell acute lymphoblastic leukemia (T-ALL). Here, the authors show that it promotes proliferation of T-ALL cells by upregulating the serine biosynthesis enzyme phosphoserine phosphatase which in turn ...
Kim R. Kampen, Laura Fancello, Tiziana Girardi, Gianmarco Rinaldi, Mélanie Planque, Sergey O. Sulima, Fabricio Loayza-Puch, Benno Verbelen, Stijn Vereecke, Jelle Verbeeck, Joyce Op de Beeck, Jonathan Royaert, Pieter Vermeersch, David Cassiman, Jan Cools, Reuven Agami, Mark Fiers, Sarah-Maria Fendt, Kim De Keersmaecker   +18 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Disturbed phospholipid metabolism in serine biosynthesis defects revealed by metabolomic profiling

, 2018
Serine biosynthesis defects are autosomal recessive metabolic disorders resulting from the deficiency of any of the three enzymes involved in de novo serine biosynthesis, specifically phosphoglycerate dehydrogenase (PGDH), phosphoserine aminotransferase (
Adam D. Kennedy, Sarah H. Elsea, Glinton, Kevin E., Grotewiel, Michael S., Lines, Matthew A., Geraghty, Michael T., Jiang, Yi, Michael T. Geraghty, Chakraborty, Pranesh, Ayman W. El-Hattab, Al-Dirbashi, Osama Y., Kennedy, Adam D., El-Hattab, Ayman W., Paul J. Benke, Michael S. Grotewiel, Pranesh Chakraborty, Sutton, V. Reid, Elsea, Sarah H., Matthew A. Lines, Benke, Paul J., Kevin E. Glinton, Osama Y. Al-Dirbashi, Yi Jiang, V. Reid Sutton   +23 more
core   +1 more source

Metabolic engineering of an industrial bacterium Zymomonas mobilis for anaerobic l-serine production

Synthetic and Systems Biotechnology
Due to the complicated metabolic and regulatory networks of l-serine biosynthesis and degradation, microbial cell factories for l-serine production using non-model microorganisms have not been reported.
Zhen Wang, Xia Wang, Xiongying Yan, Haixia Yi, Shuche He, Haoyu Zhang, Xinli Zhou, Qiaoning He, Shihui Yang   +8 more
doaj   +1 more source

p63 orchestrates serine and one carbon metabolism enzymes expression in head and neck cancer

Biology Direct, 2023
Background Head and neck squamous cell carcinoma (HNSCC) is characterized by high proliferation and limited differentiation. The altered expression of the p53 family members, and specifically of p63, represents a pivotal event in the pathogenesis of ...
Angela Cappello, Giulia Tosetti, Artem Smirnov, Carlo Ganini, Xue Yang, Yufang Shi, Ying Wang, Gerry Melino, Francesca Bernassola, Eleonora Candi   +9 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Activating Silent Glycolysis Bypasses in Escherichia coli

BioDesign Research, 2022
All living organisms share similar reactions within their central metabolism to provide precursors for all essential building blocks and reducing power. To identify whether alternative metabolic routes of glycolysis can operate in E.
Camillo Iacometti, Katharina Marx, Maria Hönick, Viktoria Biletskaia, Helena Schulz-Mirbach, Beau Dronsella, Ari Satanowski, Valérie A. Delmas, Anne Berger, Ivan Dubois, Madeleine Bouzon, Volker Döring, Elad Noor, Arren Bar-Even, Steffen N. Lindner   +14 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source