An ABC transporter containing a forkhead-associated domain interacts with a serine-threonine protein kinase and is required for growth of Mycobacterium tuberculosis in mice [PDF]
, 2005 Forkhead-associated (FHA) domains are modular phosphopeptide recognition motifs with a striking preference for phosphothreonine-containing epitopes. FHA domains have been best characterized in eukaryotic signaling pathways but have been identified in six
Curry, JM +8 more
core
Activating Silent Glycolysis Bypasses in Escherichia coli
BioDesign Research, 2022 All living organisms share similar reactions within their central metabolism to provide precursors for all essential building blocks and reducing power. To identify whether alternative metabolic routes of glycolysis can operate in E.
Camillo Iacometti +14 more
doaj +1 more source
Nature Communications, 2023 Little is known about the role of glycolysis in cellular senescence. Here, authors report that glycolysis-derived serine biosynthesis activates PKM2 to phosphorylate histone H3T11, prevent cell senescence, and promote healthy aging.
Yinsheng Wu +9 more
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Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway [PDF]
, 2003 Objective. Erythropoietin (EPO) is a key regulator of erythropoiesis, playing a role in both the proliferation and differentiation of erythroid cells.
Eggen, BJL +8 more
core +1 more source
The Effect of Single and Multiple SERAT Mutants on Serine and Sulfur Metabolism
Frontiers in Plant Science, 2018 The gene family of serine acetyltransferases (SERATs) constitutes an interface between the plant pathways of serine and sulfur metabolism. SERATs provide the activated precursor, O-acetylserine for the fixation of reduced sulfur into cysteine by ...
Mutsumi Watanabe +5 more
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ΔNp63α drives serine synthesis to promote carboplatin resistance in NSCLC
Cell Death and DiseaseSerine metabolism is a critical vulnerability in cancer; however, its role in mediating therapeutic resistance in non-small cell lung cancer (NSCLC) remains incompletely understood.
Liyuan Deng +6 more
doaj +1 more source
Dual targeting of glutamine and serine metabolism in acute myeloid leukemia
Frontiers in OncologyAcute myeloid leukemia (AML) is a heterogeneous hematological malignancy characterized by disrupted blood cell production and function. Recent investigations have highlighted the potential of targeting glutamine metabolism as a promising therapeutic ...
Kanwal M. Hameed +13 more
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Journal of Lipid Research, 1985 Serine palmitoyltransferase [EC 2.3.1.50] catalyzes the first unique reaction of sphingolipid biosynthesis. To determine whether or not different rat tissues are capable of initiating this pathway, its activity was determined for microsomes from rat ...
A H Merrill, Jr, D W Nixon, R D Williams
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Enzymatic synthesis and decarboxylation of phosphatidylserine in Tetrahymena pyriformis
Journal of Lipid Research, 1970 Cell-free extracts of the protozoan Tetrahymena pyriformis have been found to catalyze the following reactions: Phosphatidylethanolamine+L-Serine⇌Phosphatidylserine+EthanolaminePhosphatidylserine→Phosphatidylethanolamine+CO2Net:L-Serine→Ethanolamine ...
EDWARD A. DENNIS, EUGENE P. KENNEDY
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The phosphorylated pathway of serine biosynthesis links plant growth with nitrogen metabolism
, 2021 Because it is the precursor for various essential cellular components, the amino acid serine is indispensable for every living organism. In plants, serine is synthesized by two major pathways: photorespiration and the phosphorylated pathway of serine ...
Fernie, A. +16 more
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