Results 31 to 40 of about 451,320 (176)

D-3-Phosphoglycerate Dehydrogenase

Frontiers in Molecular Biosciences, 2018
l-Serine is the immediate precursor of d-serine, a major agonist of the N-methyl-d-aspartate (NMDA) receptor. l-Serine is a pivotal amino acid since it serves as a precursor to a large number of essential metabolites besides d-serine.
Gregory A. Grant, Gregory A. Grant
doaj   +1 more source

Purification of serine racemase: Biosynthesis of the neuromodulator d -serine [PDF]

Proceedings of the National Academy of Sciences, 1999
High levels of d -serine occur in mammalian brain, where it appears to be an endogenous ligand of the glycine site of N -methyl- d -aspartate receptors. In glial cultures of rat cerebral cortex,
H, Wolosker, K N, Sheth, M, Takahashi, J P, Mothet, R O, Brady, C D, Ferris, S H, Snyder   +6 more
openaire   +2 more sources

Cultivation of Cells in a Physiological Plasmax Medium Increases Mitochondrial Respiratory Capacity and Reduces Replication Levels of RNA Viruses

Antioxidants, 2021
Changes in metabolic pathways are often associated with the development of various pathologies including cancer, inflammatory diseases, obesity and metabolic syndrome.
Michail V. Golikov, Inna L. Karpenko, Anastasiya V. Lipatova, Olga N. Ivanova, Irina T. Fedyakina, Viktor F. Larichev, Natalia F. Zakirova, Olga G. Leonova, Vladimir I. Popenko, Birke Bartosch, Sergey N. Kochetkov, Olga A. Smirnova, Alexander V. Ivanov   +12 more
doaj   +1 more source

Identification and Biochemical Characterization of the Serine Biosynthetic Enzyme 3-Phosphoglycerate Dehydrogenase in Marchantia polymorpha

Frontiers in Plant Science, 2018
L-serine is an important molecule in all living organisms, and thus its biosynthesis is considered to be regulated according to demand. 3-Phosphoglycerate dehydrogenase (PGDH), the first committed enzyme of the phosphorylated pathway of L-serine ...
Hiromichi Akashi, Hiromichi Akashi, Eiji Okamura, Ryuichi Nishihama, Takayuki Kohchi, Masami Y. Hirai, Masami Y. Hirai   +6 more
doaj   +1 more source

Functional analysis of TOR complex 2 and its control of sphingolipid biosynthesis in "Saccharomyces cerevisiae" [PDF]

, 2006
sphingoid base, one of the intermediate of sphingolipids metabolites, plays a key role as a signaling molecule which activate PKH kinases and its substrates YPKs and PKC1 (Casamayor, Torrance et al. 1999; Friant, Lombardi et al.
Shioda, Ryo
core   +1 more source

The kunitz domain protein BLI-5 plays a functionally conserved role in cuticle formation in a diverse range of nematodes [PDF]

, 2010
The cuticle of parasitic nematodes performs many critical functions and is essential for proper development and for protection from the host immune response.
Stepek, Gillian, Page, Antony P., McCormack, Gillian   +2 more
core   +1 more source

Characterisation of ATP-Dependent Mur Ligases Involved in the Biogenesis of Cell Wall Peptidoglycan in Mycobacterium tuberculosis [PDF]

, 2013
ATP-dependent Mur ligases (Mur synthetases) play essential roles in the biosynthesis of cell wall peptidoglycan (PG) as they catalyze the ligation of key amino acid residues to the stem peptide at the expense of ATP hydrolysis, thus representing ...
Nicholas H Keep, Munshi, T, Sanjib Bhakta (106475), Bhakta, S, Gupta, A, Gibbons, S., Simon Gibbons (391868), Nicholas H. Keep (392673), Antima Gupta, Keep, Nicholas H., Gibbons, Simon, Bhakta, Sanjib, Evangelopoulos, Dimitrios, Juan David Guzman (392672), Gibbons, S, Simon Gibbons, Dimitrios Evangelopoulos (392671), Tulika Munshi (392669), Antima Gupta (392670), Juan David Guzman, Evangelopoulos, D, Guzman, Juan David, Gupta, Antima, Dimitrios Evangelopoulos, Munshi, Tulika, Sanjib Bhakta, Keep, NH, Guzman, Juan D., Guzman, JD, Tulika Munshi   +29 more
core   +1 more source

L-serine supplementation lowers diabetes incidence and improves blood glucose homeostasis in NOD mice. [PDF]

PLoS ONE, 2018
Sphingolipids are a diverse group of lipids with important roles in beta-cell biology regulating insulin folding and controlling apoptosis. Sphingolipid biosynthesis begins with the condensation of L-serine and palmitoyl-CoA. Here we tested the effect of
Laurits J Holm, Martin Haupt-Jorgensen, Jesper Larsen, Jano D Giacobini, Mesut Bilgin, Karsten Buschard   +5 more
doaj   +1 more source

Rational Metabolic Engineering Combined with Biosensor-Mediated Adaptive Laboratory Evolution for l-Cysteine Overproduction from Glycerol in Escherichia coli

Fermentation, 2022
l-Cysteine is an important sulfur-containing amino acid with numerous applications in the pharmaceutical and cosmetic industries. The microbial production of l-cysteine has received substantial attention, and the supply of the precursor l-serine is ...
Xiaomei Zhang, Zhenhang Sun, Jinyu Bian, Yujie Gao, Dong Zhang, Guoqiang Xu, Xiaojuan Zhang, Hui Li, Jinsong Shi, Zhenghong Xu   +9 more
doaj   +1 more source

Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells

Nature Communications, 2019
The ribosomal protein RPL10 is frequently mutated in T-cell acute lymphoblastic leukemia (T-ALL). Here, the authors show that it promotes proliferation of T-ALL cells by upregulating the serine biosynthesis enzyme phosphoserine phosphatase which in turn ...
Kim R. Kampen, Laura Fancello, Tiziana Girardi, Gianmarco Rinaldi, Mélanie Planque, Sergey O. Sulima, Fabricio Loayza-Puch, Benno Verbelen, Stijn Vereecke, Jelle Verbeeck, Joyce Op de Beeck, Jonathan Royaert, Pieter Vermeersch, David Cassiman, Jan Cools, Reuven Agami, Mark Fiers, Sarah-Maria Fendt, Kim De Keersmaecker   +18 more
doaj   +1 more source