Results 31 to 40 of about 136,827 (244)

Identification and Biochemical Characterization of the Serine Biosynthetic Enzyme 3-Phosphoglycerate Dehydrogenase in Marchantia polymorpha

Frontiers in Plant Science, 2018
L-serine is an important molecule in all living organisms, and thus its biosynthesis is considered to be regulated according to demand. 3-Phosphoglycerate dehydrogenase (PGDH), the first committed enzyme of the phosphorylated pathway of L-serine ...
Hiromichi Akashi, Hiromichi Akashi, Eiji Okamura, Ryuichi Nishihama, Takayuki Kohchi, Masami Y. Hirai, Masami Y. Hirai   +6 more
doaj   +1 more source

L-serine supplementation lowers diabetes incidence and improves blood glucose homeostasis in NOD mice. [PDF]

PLoS ONE, 2018
Sphingolipids are a diverse group of lipids with important roles in beta-cell biology regulating insulin folding and controlling apoptosis. Sphingolipid biosynthesis begins with the condensation of L-serine and palmitoyl-CoA. Here we tested the effect of
Laurits J Holm, Martin Haupt-Jorgensen, Jesper Larsen, Jano D Giacobini, Mesut Bilgin, Karsten Buschard   +5 more
doaj   +1 more source

Rational Metabolic Engineering Combined with Biosensor-Mediated Adaptive Laboratory Evolution for l-Cysteine Overproduction from Glycerol in Escherichia coli

Fermentation, 2022
l-Cysteine is an important sulfur-containing amino acid with numerous applications in the pharmaceutical and cosmetic industries. The microbial production of l-cysteine has received substantial attention, and the supply of the precursor l-serine is ...
Xiaomei Zhang, Zhenhang Sun, Jinyu Bian, Yujie Gao, Dong Zhang, Guoqiang Xu, Xiaojuan Zhang, Hui Li, Jinsong Shi, Zhenghong Xu   +9 more
doaj   +1 more source

Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells

Nature Communications, 2019
The ribosomal protein RPL10 is frequently mutated in T-cell acute lymphoblastic leukemia (T-ALL). Here, the authors show that it promotes proliferation of T-ALL cells by upregulating the serine biosynthesis enzyme phosphoserine phosphatase which in turn ...
Kim R. Kampen, Laura Fancello, Tiziana Girardi, Gianmarco Rinaldi, Mélanie Planque, Sergey O. Sulima, Fabricio Loayza-Puch, Benno Verbelen, Stijn Vereecke, Jelle Verbeeck, Joyce Op de Beeck, Jonathan Royaert, Pieter Vermeersch, David Cassiman, Jan Cools, Reuven Agami, Mark Fiers, Sarah-Maria Fendt, Kim De Keersmaecker   +18 more
doaj   +1 more source

The intervention effect of Amygdalus mongolica oil on the metabolomics and intestinal flora in pulmonary fibrosis

Frontiers in Pharmacology, 2022
Amygdalus mongolica oil is rich in unsaturated fatty acids such as inoleic acid (47.11%) and oleic acid (23.81%). Our research demonstrates that it exerts a protective effect on rat models of pulmonary fibrosis, however, little is known regarding the ...
Qian Li, Qian Li, Hong-Bing Zhou, Hong-Bing Zhou, Jia-Qi Liu, Wan-Fu Bai, Jia Wang, Zhan-Jun Yang, Min Qiu, Min Qiu, Hong Chang, Song-Li Shi, Song-Li Shi   +12 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Serine racemase is involved in d-aspartate biosynthesis [PDF]

Journal of Biochemistry, 2016
d-Aspartate is found in the nervous and reproductive system and participates in various physiological roles. While several lines of evidence suggest that this amino acid has an endogenous origin, the enzyme responsible for mammalian d-Asp biosynthesis has not yet been identified.
Tomokazu, Ito, Mika, Hayashida, Saki, Kobayashi, Natsumi, Muto, Ayumi, Hayashi, Tohru, Yoshimura, Hisashi, Mori   +6 more
openaire   +2 more sources

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

S9 protease WprP2 catalyzes uniform cleavage on the precursor peptide in RiPP biosynthesis

Communications Chemistry
Serine proteases in ribosomally synthesized and post-translationally modified peptides (RiPPs) catalyze the cleavage on the precursor peptides in the biosynthesis of RiPP natural products. Here, we identified an uncharacterized serine protease WprP2 from
Jabal Rahmat Haedar, Abujunaid Habib Khan, Suze Ma, Stefano Donadio, Chin-Soon Phan   +4 more
doaj   +1 more source

The Selectivity for Cysteine over Serine in Coenzyme A Biosynthesis [PDF]

ChemBioChem, 2005
AbstractIn the Table of Contents, the ribose moeity of coenzyme A is shown with its stereochemical centre mistakenly inverted. The correct structure appears here.magnified image
Erick, Strauss, Tadhg P, Begley
openaire   +2 more sources