Results 21 to 30 of about 136,827 (244)
Biosynthesis of L-Serine Ethanolamine Phosphodiester [PDF]
Nature, 1964 FROM recent work1 it would seem that L-serine ethanol-amine phosphodiester (L-SEP) is found only in the tissues of fish, amphibians, reptiles and birds. D-SEP, on the other hand, appears to be confined to earthworms2, where it is the biological precursor of lombricine3. The status of the work on both isomers has been summarized by Ennor and Rosenberg4.
H, ROSENBERG, A H, ENNOR, S, SUGAI
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Application of serine integrases for secondary metabolite pathway assembly in Streptomyces
Synthetic and Systems Biotechnology, 2020 Serine integrases have been shown to be efficient tools for metabolic pathway assembly. To further improve the flexibility and efficiency of pathway engineering via serine integrases, we explored how multiple orthogonally active serine integrases can be ...
Hong Gao +4 more
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The role of serine metabolism in lung cancer: From oncogenesis to tumor treatment
Frontiers in Genetics, 2023 Metabolic reprogramming is an important hallmark of malignant tumors. Serine is a non-essential amino acid involved in cell proliferation. Serine metabolism, especially the de novo serine synthesis pathway, forms a metabolic network with glycolysis ...
Xijia Zhou +4 more
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Frontiers in Oncology, 2022 Osteosarcoma (OS) is the most common primary bone sarcoma, chemoresistance becomes an obstacle to its treatment. Metabolic reprogramming is a hallmark of malignancy, targeting the metabolic pathways might provide a reasonable therapeutic strategy for OS.
Yawen Zhang +16 more
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A STUDY OF THE MECHANISM OF SERINE BIOSYNTHESIS
Journal of Biological Chemistry, 1955 Elwyn et al. (1, 2) have demonstrated that the C1 unit formed from serine is of the oxidation level of formaldehyde rather than formate. They compared the dilution of the Cl4 and deuterium of 2 ,3-deuterio-3-C14,N15L-serine that occurred during the conversion of the serine B-carbon to methyl groups in rats.
R L, KISLIUK, W, SAKAMI
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Serine Biosynthesis in Desulfovibrio desulfuricans [PDF]
Journal of Bacteriology, 1969 Cell-free extracts of Desulfovibrio desulfuricans possess enzymes which catalyze the synthesis of serine from 3-phosphoglycerate via the intermediates phosphohydroxypyruvate and phosphoserine.
G J, Germano, K E, Anderson
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D-3-Phosphoglycerate Dehydrogenase
Frontiers in Molecular Biosciences, 2018 l-Serine is the immediate precursor of d-serine, a major agonist of the N-methyl-d-aspartate (NMDA) receptor. l-Serine is a pivotal amino acid since it serves as a precursor to a large number of essential metabolites besides d-serine.
Gregory A. Grant, Gregory A. Grant
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Purification of serine racemase: Biosynthesis of the neuromodulator
Proceedings of the National Academy of Sciences, 1999 High levels of d -serine occur in mammalian brain, where it appears to be an endogenous ligand of the glycine site of N -methyl- d -aspartate receptors. In glial cultures of rat cerebral cortex,
H, Wolosker +6 more
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Antioxidants, 2021 Changes in metabolic pathways are often associated with the development of various pathologies including cancer, inflammatory diseases, obesity and metabolic syndrome.
Michail V. Golikov +12 more
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Evolution-guided yeast complementation reveals functional differences in human PSPH variants. [PDF]
FEBS Open BioAncient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Campa-Álvarez M +6 more
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