Expression of Serine Biosynthesis Pathway Genes in Breast Muscles of Iranian Native Turkeys with Divergent Feed Efficiency [PDF]
پژوهشهای علوم دامی ایران, 2022 Introduction: Feed is the main cost part of poultry production. High feed efficiency poultry produce less feed and less excrement per unit weight gain. Therefore, a comprehensive understanding of the biological mechanisms that control feed efficiency is ...
Zahra Pezeshkian +3 more
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Serine Biosynthesis Pathway Supports MYC–miR-494–EZH2 Feed-Forward Circuit Necessary to Maintain Metabolic and Epigenetic Reprogramming of Burkitt Lymphoma Cells [PDF]
Cancers, 2020 Emilia Białopiotrowicz +2 more
exaly +2 more sources
ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction
Cell Reports, 2021 Summary: The serine synthesis pathway (SSP) involving metabolic enzymes phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase 1 (PSAT1), and phosphoserine phosphatase (PSPH) drives intracellular serine biosynthesis and is indispensable ...
Xingyao Li +9 more
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PHGDH as a Key Enzyme for Serine Biosynthesis in HIF2α-Targeting Therapy for Renal Cell Carcinoma. [PDF]
Cancer Res, 2017 Continuous activation of hypoxia-inducible factor (HIF) is important for progression of renal cell carcinoma (RCC) and acquired resistance to antiangiogenic multikinase and mTOR inhibitors. Recently, HIF2α antagonists PT2385 and PT2399 were developed and
Yoshino H +10 more
europepmc +2 more sources
The NAD+ Salvage Pathway Supports PHGDH-Driven Serine Biosynthesis. [PDF]
Cell Rep, 2018 NAD+ is a key metabolic redox cofactor that is regenerated from nicotinamide through the NAD+ salvage pathway. Here, we find that inhibiting the NAD+ salvage pathway depletes serine biosynthesis from glucose by impeding the NAD+-dependent protein, 3 ...
Murphy JP +11 more
europepmc +2 more sources
Brucella abortus Depends on l-Serine Biosynthesis for Intracellular Proliferation. [PDF]
Infect Immun, 2020 L-Serine is a nonessential amino acid and a key intermediate in several relevant metabolic pathways. In bacteria, the major source of L-serine is the phosphorylated pathway, which comprises three enzymes: D-3-phosphoglycerate dehydrogenase (PGDH; SerA ...
Révora V, Marchesini MI, Comerci DJ.
europepmc +2 more sources
Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway. [PDF]
EMBO Mol Med, 2020 During obesity, macrophages infiltrate the breast tissue leading to low-grade chronic inflammation, a factor considered responsible for the higher risk of breast cancer associated with obesity.
Wilcz-Villega E +16 more
europepmc +3 more sources
Biosynthesis of L-Serine Ethanolamine Phosphodiester [PDF]
Nature, 1964 FROM recent work1 it would seem that L-serine ethanol-amine phosphodiester (L-SEP) is found only in the tissues of fish, amphibians, reptiles and birds. D-SEP, on the other hand, appears to be confined to earthworms2, where it is the biological precursor of lombricine3. The status of the work on both isomers has been summarized by Ennor and Rosenberg4.
H, ROSENBERG, A H, ENNOR, S, SUGAI
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Frontiers in Oncology, 2022 Osteosarcoma (OS) is the most common primary bone sarcoma, chemoresistance becomes an obstacle to its treatment. Metabolic reprogramming is a hallmark of malignancy, targeting the metabolic pathways might provide a reasonable therapeutic strategy for OS.
Yawen Zhang +16 more
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PLoS Genetics, 2020 Sphingolipids are abundant and essential molecules in eukaryotes that have crucial functions as signaling molecules and as membrane components. Sphingolipid biosynthesis starts in the endoplasmic reticulum with the condensation of serine and palmitoyl ...
Bianca M Esch +10 more
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