Results 21 to 30 of about 451,320 (176)

‐serine biosynthesis [PDF]

, 2023
De novo l-serine biosynthesis in the mammalian astrocytes proceeds via a linear, three-step pathway (the phosphorylated pathway) catalysed by 3-phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase (PSAT) and phosphoserine phosphatase ...
Giulia Murtas, Mozzarelli, Andrea, Valentina Rabattoni, Andrea Mozzarelli, Murtas, Giulia, Sacchi, Silvia, Stefano Bruno, Loredano Pollegioni, Campanini, Barbara, Pollegioni, Loredano, Peracchi, Alessio, Bruno, Stefano, Silvia Sacchi, Barbara Campanini, Marchesani, Francesco, Alessio Peracchi, Rabattoni, Valentina, Francesco Marchesani   +17 more
core   +1 more source

Parallel analysis of global garlic gene expression and alliin content following leaf wounding

BMC Plant Biology, 2021
Background Allium sativum (garlic) is an economically important food source and medicinal plant rich in sulfides and other protective substances such as alliin, the precursor of allicin biosynthesis. Cysteine, serine and sulfur is the precursor of alliin
Xuqin Yang, Yiren Su, Jiaying Wu, Wen Wan, Huijian Chen, Xiaoying Cao, Junjuan Wang, Zhong Zhang, Youzhi Wang, Deliang Ma, G. J. Loake, Jihong Jiang   +11 more
doaj   +1 more source

The malate-aspartate shuttle is important for de novo serine biosynthesis

Cell Reports, 2023
Summary: The malate-aspartate shuttle (MAS) is a redox shuttle that transports reducing equivalents across the inner mitochondrial membrane while recycling cytosolic NADH to NAD+.
Melissa H. Broeks, Nils W.F. Meijer, Denise Westland, Marjolein Bosma, Johan Gerrits, Hannah M. German, Jolita Ciapaite, Clara D.M. van Karnebeek, Ronald J.A. Wanders, Fried J.T. Zwartkruis, Nanda M. Verhoeven-Duif, Judith J.M. Jans   +11 more
doaj   +1 more source

Biosynthesis of L-Serine Ethanolamine Phosphodiester [PDF]

Nature, 1964
FROM recent work1 it would seem that L-serine ethanol-amine phosphodiester (L-SEP) is found only in the tissues of fish, amphibians, reptiles and birds. D-SEP, on the other hand, appears to be confined to earthworms2, where it is the biological precursor of lombricine3. The status of the work on both isomers has been summarized by Ennor and Rosenberg4.
H, ROSENBERG, A H, ENNOR, S, SUGAI
openaire   +2 more sources

Application of serine integrases for secondary metabolite pathway assembly in Streptomyces

Synthetic and Systems Biotechnology, 2020
Serine integrases have been shown to be efficient tools for metabolic pathway assembly. To further improve the flexibility and efficiency of pathway engineering via serine integrases, we explored how multiple orthogonally active serine integrases can be ...
Hong Gao, Gabrielle Taylor, Stephanie K. Evans, Paul C.M. Fogg, Margaret C.M. Smith   +4 more
doaj   +1 more source

The role of serine metabolism in lung cancer: From oncogenesis to tumor treatment

Frontiers in Genetics, 2023
Metabolic reprogramming is an important hallmark of malignant tumors. Serine is a non-essential amino acid involved in cell proliferation. Serine metabolism, especially the de novo serine synthesis pathway, forms a metabolic network with glycolysis ...
Xijia Zhou, Chang Tian, Yingshu Cao, Min Zhao, Ke Wang   +4 more
doaj   +1 more source

Regulation of cyclic lipopeptide biosynthesis in Pseudomonas fluorescens by the ClpP protease [PDF]

, 2009
Cyclic lipopeptides produced by Pseudomonas species exhibit potent surfactant and broad-spectrum antibiotic properties. Their biosynthesis is governed by large multimodular nonribosomal peptide synthetases, but little is known about the genetic ...
Bruijn, I., de, Raaijmakers, J.M., de Bruijn, I.   +2 more
core   +1 more source

Ailanthone Inhibits Proliferation, Migration and Invasion of Osteosarcoma Cells by Downregulating the Serine Biosynthetic Pathway

Frontiers in Oncology, 2022
Osteosarcoma (OS) is the most common primary bone sarcoma, chemoresistance becomes an obstacle to its treatment. Metabolic reprogramming is a hallmark of malignancy, targeting the metabolic pathways might provide a reasonable therapeutic strategy for OS.
Yawen Zhang, Runze Gong, Yong Liu, Xipeng Sun, Jinrong Liang, Yan Zhou, Yaling Wang, Wenxi Yu, Yonggang Wang, Lina Tang, Aina He, Zan Shen, Yang Yao, Haiyan Hu, Xin Liu, Xin Liu, Jianjun Zhang   +16 more
doaj   +1 more source

A STUDY OF THE MECHANISM OF SERINE BIOSYNTHESIS

Journal of Biological Chemistry, 1955
Elwyn et al. (1, 2) have demonstrated that the C1 unit formed from serine is of the oxidation level of formaldehyde rather than formate. They compared the dilution of the Cl4 and deuterium of 2 ,3-deuterio-3-C14,N15L-serine that occurred during the conversion of the serine B-carbon to methyl groups in rats.
R L, KISLIUK, W, SAKAMI
openaire   +2 more sources

Serine Biosynthesis in Desulfovibrio desulfuricans [PDF]

Journal of Bacteriology, 1969
Cell-free extracts of Desulfovibrio desulfuricans possess enzymes which catalyze the synthesis of serine from 3-phosphoglycerate via the intermediates phosphohydroxypyruvate and phosphoserine.
G J, Germano, K E, Anderson
openaire   +2 more sources